Vav1^tm2Tyb
Targeted Allele Detail

Summary

• Symbol: Vav1^tm2Tyb
• Name: vav 1 oncogene; targeted mutation 2, Victor L J Tybulewicz
• MGI ID: MGI:3686972
• Synonyms: Vav1^R422G
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm2Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113270
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Arginine 422 was mutated to glycine in exon 13 (R422G). A floxed neo was included in intron 9. Cre-mediated excision removed the neo cassette upon transmission from male chimeras. (J:113270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 58 strains or lines available

References

• Original: J:113270 Prisco A, et al., Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity. 2005 Sep;23(3):263-74
• All: 2 reference(s)