All Phenotypes Vav1<tm2Tyb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv	MGI:3689307
hm2	Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd	MGI:3689308
cx3	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv	MGI:3689310
cx4	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL	MGI:3689309

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-negative T cell number ( J:113270 )

• decreased compared to controls; however, this decrease is less than that in homozygous null mice

• significant decrease in the number of DN4 cells suggesting a partial block in development between the DN3 and DN4 stages

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• slight but significant reduction in CD4+ cell numbers in the thymus, although not as large as in homozygous null mice

• cell numbers in the spleen and lymph nodes are similar to controls

abnormal T cell physiology ( J:113270 )

• significant reduction in CD5 and CD2 expression, although not as much as in homozygous null mice

• reduced T cell receptor-induced calcium fluxes, although not as much as in homozygous null mice

decreased T cell proliferation ( J:113270 )

• reduced CD4+ cell proliferation in response to anti-CD3 alone or anti-CD3 plus anti-CD28; however proliferation is increased compared to homozygous null mice and proliferation of CD8+ cells is similar to controls

hematopoietic system

decreased double-negative T cell number ( J:113270 )

• decreased compared to controls; however, this decrease is less than that in homozygous null mice

• significant decrease in the number of DN4 cells suggesting a partial block in development between the DN3 and DN4 stages

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• slight but significant reduction in CD4+ cell numbers in the thymus, although not as large as in homozygous null mice

• cell numbers in the spleen and lymph nodes are similar to controls

abnormal T cell physiology ( J:113270 )

• significant reduction in CD5 and CD2 expression, although not as much as in homozygous null mice

• reduced T cell receptor-induced calcium fluxes, although not as much as in homozygous null mice

decreased T cell proliferation ( J:113270 )

cellular

decreased T cell proliferation ( J:113270 )

Allelic Composition	Vav1^tm2Tyb/Vav1^tm2Tyb
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:113270 )

• deletion of CD4+ cells expressing Vbeta5, 11, and 12 is greater than in homozygous null mice but less than in wild-type mice, suggesting impaired negative selection

abnormal CD4-positive, alpha beta T cell morphology ( J:113270 )

hematopoietic system

abnormal negative T cell selection ( J:113270 )

• deletion of CD4+ cells expressing Vbeta5, 11, and 12 is greater than in homozygous null mice but less than in wild-type mice, suggesting impaired negative selection

abnormal CD4-positive, alpha beta T cell morphology ( J:113270 )

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

hematopoietic system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Tg(TcrAND)53Hed mutation (2 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

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