Rag1^tm1.1Sadu
Targeted Allele Detail

Summary

• Symbol: Rag1^tm1.1Sadu
• Name: recombination activating 1; targeted mutation 1.1, Sandra Dueber
• MGI ID: MGI:4414763
• Synonyms: Indu-Rag1^fl
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^tm1.1Sadu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding region in exon 2 was replaced with an FRT flanked neo cassette and an inverted coding region flanked by loxP sites in reverse orientation. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination is required to re-establish endogenous expression. (J:155473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 133 strains or lines available

References

• Original: J:155473 Duber S, et al., Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 2009 Dec 3;114(24):4960-7
• All: 8 reference(s)