Ctla4^tm1All
Targeted Allele Detail

Summary

• Symbol: Ctla4^tm1All
• Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1, James P Allison
• MGI ID: MGI:2180670
• Synonyms: CTLA-4^-, CTLA-4 KO, Ctla4o, Ctla4^o
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^tm1All page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42481
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• The insertion of neomycin selection cassette under the control of a PGK promoter disrupted exon 3. (J:42481)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 53 strains or lines available

References

• Original: J:42481 Chambers CA, et al., Thymocyte development is normal in CTLA-4-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9296-301
• All: 39 reference(s)