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early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
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Transcription Start Site | Location | Distance from Gene 5'-end |
Tssr6954 | Chr1:60948152-60948192 (+) | -12 bp |
Tssr6955 | Chr1:60948244-60948261 (+) | 69 bp |
Tssr6956 | Chr1:60948307-60948318 (+) | 129 bp |
Tssr6957 | Chr1:60948382-60948425 (+) | 220 bp |
Tssr6958 | Chr1:60948509-60948515 (+) | 328 bp |
Tssr6959 | Chr1:60950226-60950231 (+) | 2,045 bp |
Tssr6960 | Chr1:60950240-60950253 (+) | 2,063 bp |
Tssr6961 | Chr1:60950271-60950281 (+) | 2,092 bp |
Tssr6962 | Chr1:60951084-60951091 (+) | 2,904 bp |
Tssr6963 | Chr1:60952825-60952831 (+) | 4,644 bp |
Tssr6964 | Chr1:60953079-60953093 (+) | 4,902 bp |
Tssr6965 | Chr1:60953783-60953819 (+) | 5,617 bp |
QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
Idd5 | Chr1, syntenic | J:71276 | The authors mention the following genes mapping near Idd5 as possible candidates: Bcl2, Casp8, and Ctla4. | |
Idd5.1 | Chr1, syntenic | Chr1:57728276-62946882 | J:83656 | Ctla4 is a previously identified candidate gene for the diabetes susceptibility QTL Idd5a. A silent polymorphism was previously identified in exon2 of Ctla4. In this study a splice variant of Ctla4 was identified that is generated by the skipping of exon2. This isoform encodes a transmembrane protein lacking the CD80/CD86 binding domain and is expressed four-fold greater in activated and resting spleen cells of diabetes resistant strains C57BL/10J and C57BL/6J. It is believed that an exon 2 SNP at nucleotide 77 is responsible forthe difference in mRNA expression. Resistant strains C57BL/10J and C57BL/6J carry an A allele at nucleotide 77 whereas susceptible strain NOD carries the mutant G allele. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/24/2024 MGI 6.24 |
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