Tg(KRT5-rtTA)T2D6Sgkd
Transgene Detail

Summary

• Symbol: Tg(KRT5-rtTA)T2D6Sgkd
• Name: transgene insertion T2D6, Silvio Gutkind
• MGI ID: MGI:5292234
• Synonyms: K5-rtTa
• Transgene: Tg(KRT5-rtTA)T2D6Sgkd Location: unknown
• Alliance: Tg(KRT5-rtTA)T2D6Sgkd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The K5-rtTA transgene was designed with a bovine keratin 5 (KRT5) promoter driving expression of the reverse tetracycline transactivator gene (rtTA) with a nuclear localization signal (nls), followed by a polyadenylation signal. Line T2D6 was generated. (J:94955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94955 Vitale-Cross L, et al., Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15;64(24):8804-7
• All: 13 reference(s)