Bcl6b^tm2Dent
Targeted Allele Detail

Summary

• Symbol: Bcl6b^tm2Dent
• Name: B cell CLL/lymphoma 6, member B; targeted mutation 2, Alexander Dent
• MGI ID: MGI:3719094
• Synonyms: Bazf^-
• Gene: Bcl6b Location: Chr11:70114954-70120624 bp, - strand Genetic Position: Chr11, 42.99 cM, cytoband B4
• Alliance: Bcl6b^tm2Dent page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encoding 124 C-terminal amino acids was replaced by a pgk-neo cassette. This deleted region contained all of the zinc finger amino acids, and thus the targeted gene was rendered incapable of producing a DNA binding protein by alternative splicing. RT-PCR confirmed absence of transcript from mutant lungs. (J:123621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6b Mutation: 14 strains or lines available

References

• Original: J:123621 Broxmeyer HE, et al., Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol. 2007 Aug;27(15):5275-85
• All: 1 reference(s)