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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Igh
immunoglobulin heavy chain complex
MGI:96442
126 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:145691
spontaneous chromosome breakage J:145691
Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:145691
spontaneous chromosome breakage J:145691
Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
normal immune system phenotype J:194603
Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
involves: C57BL/6 * CBA/JNCrlj * SJL
abnormal immunoglobulin heavy chain V(D)J recombination J:194603
Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 * C57BL/6 * CBA/JNCrlj * SJL
abnormal immunoglobulin heavy chain V(D)J recombination J:194603
Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
involves: C57BL/6 * CBA
induced chromosome breakage J:145691
Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 * C57BL/6 * CBA
abnormal class switch recombination J:159173
Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
abnormal immunoglobulin heavy chain V(D)J recombination J:194603
Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
abnormal immunoglobulin heavy chain V(D)J recombination J:194603
Blnktm1Kplm/Blnktm1Kplm
Ightm4Cgn/Igh+
Igktm1Rsky/Igk+
involves: 129P2/OlaHsd
abnormal B cell differentiation J:120460
decreased B cell number J:120460
increased pre-B cell number J:120460
increased transitional stage B cell number J:120460
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Ightm1Mnz/Ightm1Mnz
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:75653
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Ightm2Mnz/Ightm2Mnz
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:75653
Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Igh+
involves: 129 * BALB/c * C57BL/6
abnormal class switch recombination J:125719
Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky
involves: 129 * BALB/c * C57BL/6
abnormal B cell activation J:125719
decreased B-1a cell number J:125719
Cd79atm4.1Cgn/Cd79atm4.1Cgn
Ightm1.2Rsky/Igh+
involves: BALB/c * C57BL/6
abnormal pro-B cell differentiation J:125719
Cd79atm5.1Cgn/Cd79a+
Ightm1.2Rsky/Igh+
involves: 129 * BALB/c * C57BL/6
abnormal class switch recombination J:125719
Cd79atm5.1Cgn/Cd79atm5.1Cgn
Ightm1.2Rsky/Igh+
involves: 129 * BALB/c * C57BL/6
abnormal class switch recombination J:125719
Cd79atm5.1Cgn/Cd79atm5.1Cgn
Ightm1.2Rsky/Ightm1.2Rsky
involves: 129 * BALB/c * C57BL/6
abnormal B cell morphology J:125719
abnormal class switch recombination J:125719
decreased immature B cell number J:125719
decreased mature B cell number J:125719
decreased pre-B cell number J:125719
decreased T cell number J:125719
increased B-1b cell number J:125719
increased pro-B cell number J:125719
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL
abnormal spleen B cell follicle morphology J:278399
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
NOD.Cg-Emv30b Prkdcscid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs
normal homeostasis/metabolism phenotype J:274578
Ezh2tm1Tara/Ezh2tm1Tara
Ightm2Cgn/?
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
normal immune system phenotype J:83216
Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Ightm2Cgn/Ightm2Cgn
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
absent B cells J:189078
absent B-2 B cells J:189078
decreased B-1 B cell number J:189078
Fnip1tm1.2Baba/Fnip1tm1.2Baba
Ightm2Cgn/Ightm2Cgn
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
absent B cells J:189078
absent B-2 B cells J:189078
decreased B-1 B cell number J:189078
Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv
increased B cell number J:157297
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv
absent marginal zone B cells J:157297
increased B cell number J:157297
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Igh+
Igktm1Jiac/Igktm1Jiac
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
decreased mature B cell number J:133032
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igk+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
decreased mature B cell number J:133032
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igktm1Jiac
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
abnormal B cell physiology J:133032
abnormal B cell selection J:133032
decreased mature B cell number J:133032
Gpr183tm1.2Rbr/Gpr183tm1.2Rbr
Ightm1Rbr/Ightm1Rbr
Tg(IgkHyHEL10)1Rbr/0
involves: C57BL/6 * FVB/N * SJL
abnormal B cell physiology J:151883
abnormal B cell proliferation J:151883
decreased B cell number J:151883
decreased IgG1 level J:151883
decreased IgM level J:151883
decreased plasma cell number J:151883
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sortm4(Ikbkb)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6
increased B cell number J:157297
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6
decreased mature B cell number J:157297
Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6
decreased mature B cell number J:157297
H2axtm1Nus/H2axtm1Nus
Ightm1Mnz/Ightm1Mnz
involves: 129P2/OlaHsd
normal immune system phenotype J:120658
H2axtm1Nus/H2axtm1Nus
Ightm2Mnz/Ightm2Mnz
involves: 129P2/OlaHsd
normal immune system phenotype J:120658
Igh-Jtm1Cgn/Ightm1Leck
involves: 129P2/OlaHsd * C57BL/6
abnormal immunoglobulin light chain V-J recombination J:144033
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd
decreased mature B cell number J:157297
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Not Specified
decreased B cell number J:79299
decreased follicular B cell number J:79299
decreased marginal zone B cell number J:79299
Igh-Jtm1Cgn/Ightm11.1Cgn
involves: 129P2/OlaHsd
abnormal B cell differentiation J:113434
Igh-Jtm1Dhu/Ightm1Tim
involves: 129X1/SvJ * C57BL/6
abnormal B cell differentiation J:88410
abnormal B cell morphology J:87624
abnormal immune system organ morphology J:87624
abnormal spleen marginal zone morphology J:87624
abnormal spleen morphology J:87624
Igh-Jtm1Dhu/Ightm2Tim
involves: 129X1/SvJ * C57BL/6
abnormal lymph node morphology J:87624
abnormal spleen morphology J:87624
decreased marginal zone B cell number J:87624
Igh-Jtm1Dhu/Ightm3Tim
involves: 129 * C57BL/6
abnormal B cell differentiation J:102308
decreased B cell number J:102308
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
involves: 129P2/OlaHsd
abnormal B cell differentiation J:137738
abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
involves: 129P2/OlaHsd
abnormal B cell differentiation J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
involves: 129P2/OlaHsd
abnormal B cell morphology J:23827
abnormal immunoglobulin level J:23827
increased mature B cell number J:23827
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2BM)7Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:139792
decreased B cell number J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2CM)2Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:139792
decreased B cell number J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG1/2)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd * C57BL/6J
abnormal B cell morphology J:70620
abnormal immunoglobulin heavy chain V(D)J recombination J:70620
abnormal immunoglobulin level J:70620
abnormal immunoglobulin light chain V-J recombination J:70620
increased mature B cell number J:70620
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
involves: 129P2/OlaHsd
abnormal B cell differentiation J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
normal immune system phenotype J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
involves: 129P2/OlaHsd
abnormal B cell differentiation J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
involves: 129P2/OlaHsd
abnormal immunoglobulin level J:137738
decreased mature B cell number J:137738
normal immune system phenotype J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
involves: 129P2/OlaHsd
abnormal B cell differentiation J:137738
abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
involves: 129P2/OlaHsd
abnormal B cell morphology J:23827
abnormal immunoglobulin level J:23827
increased late pro-B cell number J:23827
increased mature B cell number J:23827
IghdeltaD/Ightm11.1Cgn
involves: C57BL/6 * DBA/2
abnormal B cell differentiation J:113434
Ightm1(IGH)Vlcg/Ightm1(IGH)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
reduced male fertility J:208619
Ightm1(IGH)Vlcg/Ightm1(IGH)Vlcg
Igktm1(IGK)Vlcg/Igktm1(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
normal immune system phenotype J:208620
reduced male fertility J:208619
Ightm1(Ighppc1-5)Cche/Igh+
B6.Cg-Ightm1(Ighppc1-5)Cche
normal immune system phenotype J:138356
increased autoantibody level J:138356
Ightm1(Myc)Janz/Igh+
involves: 129X1/SvJ * C57BL/6
abnormal tumor morphology J:160845
enlarged lymph nodes J:96785
enlarged spleen J:96785
increased B cell apoptosis J:96785
increased B cell derived lymphoma incidence J:96785, J:160845
increased B cell proliferation J:96785
increased plasmacytoma incidence J:96785, J:160845
increased tumor incidence J:96785, J:160845
lymphoid hyperplasia J:96785
Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
involves: 129S/Sv * C57BL/6
enlarged liver J:150341
enlarged lymph nodes J:150341
enlarged spleen J:150341
increased B cell derived lymphoma incidence J:150341
increased lymphoma incidence J:150341
increased splenocyte proliferation J:150341
premature death J:150341
Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)A5Wmk/0
involves: 129X1/SvJ * C57BL/6 * FVB/N
abnormal tumor morphology J:160845
increased B cell derived lymphoma incidence J:160845
increased plasmacytoma incidence J:160845
increased tumor incidence J:160845
Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)D3Wmk/0
involves: 129X1/SvJ * C57BL/6 * FVB/N
abnormal tumor morphology J:160845
increased B cell derived lymphoma incidence J:160845
increased plasmacytoma incidence J:160845
increased tumor incidence J:160845
Ightm1(PAX5)Mbu/Igh+
B6.Cg-Ightm1(PAX5)Mbu
abnormal heart morphology J:118111
abnormal kidney morphology J:118111
abnormal liver morphology J:118111
abnormal lung morphology J:118111
abnormal lymph node morphology J:118111
abnormal salivary gland morphology J:118111
abnormal spleen morphology J:118111
abnormal T cell differentiation J:118111
abnormal thymus morphology J:118111
decreased double-negative T cell number J:118111
decreased double-positive T cell number J:118111
enlarged lymph nodes J:118111
enlarged spleen J:118111
enlarged thymus J:118111
increased lymphoma incidence J:118111
increased pro-B cell number J:118111
increased T cell derived lymphoma incidence J:118111
premature death J:118111
thymus hypoplasia J:118111
Ightm1(PAX5)Mbu/Igh+
Pax5tm1Mbu/Pax5tm1Mbu
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
abnormal B cell differentiation J:118111
decreased B cell number J:118111
normal immune system phenotype J:118111
Ightm1(PAX5)Mbu/Ightm1(PAX5)Mbu
B6.Cg-Ightm1(PAX5)Mbu
abnormal heart morphology J:118111
abnormal kidney morphology J:118111
abnormal liver morphology J:118111
abnormal lung morphology J:118111
abnormal lymph node morphology J:118111
abnormal salivary gland morphology J:118111
abnormal spleen morphology J:118111
abnormal T cell differentiation J:118111
abnormal thymus morphology J:118111
decreased double-negative T cell number J:118111
decreased double-positive T cell number J:118111
enlarged lymph nodes J:118111
enlarged spleen J:118111
enlarged thymus J:118111
increased lymphoma incidence J:118111
increased pro-B cell number J:118111
increased T cell derived lymphoma incidence J:118111
premature death J:118111
thymus hypoplasia J:118111
Ightm1(VH558)Mss/Igh+
involves: FVB/N
abnormal B cell differentiation J:130421
Ightm1(VH558)Mss/Ightm1(VH558)Mss
involves: FVB/N
abnormal B cell differentiation J:130421
Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
involves: C57BL/6N * FVB/N
decreased IgM level J:205766
decreased immature B cell number J:205766
increased B cell number J:205766
Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
Igktm1.1(b12)Nemz/Igktm1.1(b12)Nemz
involves: C57BL/6N * C57BL/6NTac * FVB/N
decreased IgM level J:205766
decreased immature B cell number J:205766
normal immune system phenotype J:205766
increased B cell number J:205766
Ightm1.1(Igh564)Tik/Ightm1.1(Igh564)Tik
Igktm1(Igk564)Tik/Igktm1(Igk564)Tik
B6.129S4-Igktm1(Igk564)Tik Ightm1(Igh564)Tik
abnormal glomerular mesangium morphology J:113555
abnormal podocyte morphology J:113555
expanded mesangial matrix J:113555
glomerulonephritis J:113555
increased mesangial cell number J:113555
podocyte foot process effacement J:113555
Ightm1.1(Tag)Rwhe/Igh+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell morphology J:150315
enlarged spleen J:150315
increased B cell number J:150315
increased chronic lymphocytic leukemia incidence J:150315
increased leukemia incidence J:150315
lymph node hyperplasia J:150315
Ightm1.1(Tag)Rwhe/Igh+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
increased chronic lymphocytic leukemia incidence J:150315
increased leukemia incidence J:150315
Ightm1.1Twin/Ightm1.1Twin
Plcg2Ali5/Plcg2+
involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6
normal immune system phenotype J:174233
increased B-1a cell number J:174233
Ightm1.1Twin/Ightm1.1Twin
Siglecgtm1Lnit/Siglecgtm1Lnit
involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
normal immune system phenotype J:174233
Ightm1.2Rsky/Igh+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
involves: BALB/c * C57BL/6
decreased mature B cell number J:125719
Ightm1Cys/Igh+
Tg(Igk)5Cys/0
B6.Cg-Ightm1Cys Tg(Igk)5Cys
abnormal B cell physiology J:118931
normal immune system phenotype J:118931
Ightm1Cys/Igh+
Tg(Igk)5Cys/0
Tg(UBC-GFP)30Scha/Tg(UBC-GFP)30Scha
involves: 129X1/SvJ * C57BL/6 * CBA
normal immune system phenotype J:118931
Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0
involves: C57BL/6 * SJL
increased B cell number J:115292
Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
increased B cell number J:115292
Ightm1Ktom/Ightm1Ktom
Igktm1Ktom/Igktm1Ktom
Tc(HSA14)SC20Ktom/0
Tc(HSA2)W23Ktom/0
involves: C57BL/6NCrlj * CBA/JNCrlj * ICR
abnormal B cell physiology J:59894
Ightm1Ktom/Ightm1Ktom
Tc(HSA2)W23Ktom/0
involves: C57BL/6NCrlj * CBA/JNCrlj * ICR
abnormal B cell physiology J:59894
Ightm1Leck/Igh+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell morphology J:144033
abnormal B-1a B cell morphology J:144033
abnormal immature B cell morphology J:144033
abnormal immunoglobulin light chain V-J recombination J:144033
abnormal mature B cell morphology J:144033
Ightm1Leck/Ightm1Leck
involves: 129P2/OlaHsd * C57BL/6
decreased B cell number J:144033
Ightm1Mnz/Ightm1Mnz
Dis3tm1.1Uba/Dis3tm1.1Uba
Aicdatm1(cre)Uba/Aicda+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
abnormal somatic hypermutation frequency J:302856
Ightm1Mnz/Ightm1Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
abnormal B cell physiology J:75653
increased B cell proliferation J:75653
Ightm1Rbr/Igh+
Tg(IgkHyHEL10)1Rbr/0
involves: C57BL/6
abnormal B cell morphology J:132538
abnormal B-2 B cell morphology J:132538
increased IgA level J:132538
increased IgG1 level J:132538
increased IgG2a level J:132538
increased IgG2b level J:132538
increased IgG3 level J:132538
increased IgM level J:132538
increased immature B cell number J:132538
increased immunoglobulin level J:132538
Ightm1Rbr/Igh+
Tg(IgkHyHEL10)1Rbr/0
Tg(ML5sHEL)5Ccg/0
involves: C57BL/6 * C57BL/6JSfd
abnormal B cell anergy J:132538
abnormal B cell morphology J:132538
decreased follicular B cell number J:132538
decreased marginal zone B cell number J:132538
increased immature B cell number J:132538
Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
reduced male fertility J:208619
Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Igktm2(IGK)Vlcg/Igktm2(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
normal immune system phenotype J:208620
reduced male fertility J:208619
Ightm2.1(4E10)Nemz/Ightm2.1(4E10)Nemz
Igktm2.1(4E10)Nemz/Igktm2.1(4E10)Nemz
involves: C57BL/6 * C57BL/6N * C57BL/6NTac * FVB/N
decreased B cell number J:101977
decreased IgG level J:101977
decreased IgM level J:101977
Ightm2.1(Tag)Rwhe/Igh+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell morphology J:150315
enlarged spleen J:150315
increased B cell number J:150315
increased chronic lymphocytic leukemia incidence J:150315
increased leukemia incidence J:150315
lymph node hyperplasia J:150315
Ightm2.1(Tag)Rwhe/Igh+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
increased chronic lymphocytic leukemia incidence J:150315
increased leukemia incidence J:150315
Ightm2Cgn/Igh+
Rr158tm1Cgn/Rr158tm1Cgn
Arhgef1tm1.1Rmt/Arhgef1tm1.1Rmt
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:113295
Ightm2Cgn/Igh+
Xrcc6tm1Fwa/Xrcc6tm1Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
abnormal B cell differentiation J:44361
Ightm2Cgn/Igh+
Igktm1Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
abnormal B cell differentiation J:111431
absent pre-B cells J:111431
Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
involves: 129P2/OlaHsd
abnormal class switch recombination J:150435
Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Prkdcscid/Prkdcscid
involves: 129P2/OlaHsd * BALB/c * C57BL/Ka
abnormal class switch recombination J:150435
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac
abnormal class switch recombination J:126758
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac
abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
abnormal B cell physiology J:75653
increased B cell proliferation J:75653
Ightm2Rsky/Igh+
Igktm1Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
abnormal B cell differentiation J:111431
Ightm2Rsky/Igh+
Igktm2Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
abnormal B cell differentiation J:111431
Ightm3(IGH)Vlcg/Ightm3(IGH)Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
decreased litter size J:277644
impaired fertilization J:277644
impaired sperm migration in female genital tract J:277644
reduced male fertility J:277644
normal reproductive system phenotype J:277644
Ightm3.1(IGH)Vlcg/Ightm3.1(IGH)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
reduced male fertility J:208619
Ightm3.1(IGH)Vlcg/Ightm3.1(IGH)Vlcg
Igktm3.1(IGK)Vlcg/Igktm3.1(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N
normal immune system phenotype J:208620
reduced male fertility J:208619
Ightm3.1Tim/Igh+
involves: 129 * C57BL/6
abnormal B cell differentiation J:102308
abnormal bone marrow cell number J:102308
abnormal spleen B cell follicle morphology J:102308
Ightm3Tim/Igh+
involves: 129 * C57BL/6
abnormal B cell differentiation J:102308
abnormal bone marrow cell number J:102308
abnormal spleen B cell follicle morphology J:102308
Ightm4.1(IGH,Adam6a,Adam6b)Vlcg/Ightm4.1(IGH,Adam6a,Adam6b)Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac * SJL
normal reproductive system phenotype J:277644
Ightm4Cog/Igh+
involves: 129S2/SvPas * C57BL/6
decreased IgM level J:109988
increased IgA level J:109988
Ightm4Cog/Ightm4Cog
involves: 129S2/SvPas * C57BL/6
absent Peyer's patches J:109988
absent spleen germinal center J:109988
small spleen J:109988
Ighmtm1Cgn/Ightm3Tim
involves: 129 * C57BL/6
abnormal B cell differentiation J:102308
decreased B cell number J:102308
Ighmtm1Msn/Ighmtm1Msn
Tg(Igh-6)1Msn/?
B6.129S-Ighmtm1Msn
abnormal B-1a B cell morphology J:80656
abnormal splenic cell ratio J:80656
decreased follicular B cell number J:80656
decreased IgM level J:80656
increased marginal zone B cell number J:80656
Il2rgtm1Krf/Il2rgtm1Krf
Tg(BCL2/IGH)1Tjd/0
either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N)
decreased thymocyte number J:114561
Inpp5dtm1Rav/Inpp5dtm1Rav
Cd79atm1(cre)Reth/Cd79a+
Tg(IghAb36-65)1Wys/0
involves: 129 * BALB/c * C57BL/6 * FVB/N
abnormal B cell anergy J:178833
abnormal B cell negative selection J:178833
decreased B cell number J:178833
increased autoantibody level J:178833
increased plasma cell number J:178833
Mef2btm2Rdf/Mef2b+
Tg(BCL2/IGH)M23Tjd/0
Tg(Cr2-cre)3Cgn/0
involves: C3H/He * C57BL/6
increased follicular lymphoma incidence J:265465
increased lymphoma incidence J:265465
Tg(BCL2/IGH)1Tjd/?
involves: C3H/He * C57BL/6
abnormal B cell physiology J:81147
abnormal lymph node morphology J:81147
abnormal mononuclear cell differentiation J:81147
enlarged lymph nodes J:81147
enlarged spleen J:81147
increased B cell number J:81147
increased spleen white pulp amount J:81147
spleen hyperplasia J:81147
Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0
involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J
abnormal spleen marginal zone morphology J:94116
ascites J:94116
decreased B cell apoptosis J:94116
enlarged lymph nodes J:94116
enlarged spleen J:94116
increased B cell number J:94116
increased B-1a cell number J:94116
increased B-1b cell number J:94116
increased chronic lymphocytic leukemia incidence J:94116
increased marginal zone B cell number J:94116
increased small lymphocytic lymphoma incidence J:94116
increased spleen weight J:94116
pleural effusion J:94116
premature death J:94116
Tg(BCL2/IGH)M23Tjd/?
involves: C3H/He * C57BL/6
abnormal B cell physiology J:81147
abnormal lymph node morphology J:81147
abnormal mononuclear cell differentiation J:81147
enlarged lymph nodes J:81147
enlarged spleen J:81147
increased B cell number J:81147
increased spleen white pulp amount J:81147
spleen hyperplasia J:81147
Tg(IGH@,IGL@)1Skmr/0
B6.Cg-Tg(IGH@,IGL@)1Skmr
no abnormal phenotype detected J:131009
Tg(IGH@yH1)2BJkbv/0
involves: 129P2/OlaHsd
abnormal B cell morphology J:23827
abnormal immunoglobulin heavy chain V(D)J recombination J:23827
abnormal immunoglobulin level J:23827
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
involves: 129P2/OlaHsd
abnormal B cell morphology J:23827
abnormal immunoglobulin level J:23827
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs
increased susceptibility to autoimmune diabetes J:274578
Tg(SV40-Igh-64C8)H3Hon/0
Tg(SV40-Igk4C8)L1Hon/0
involves: C57BL/6
abnormal B cell clonal deletion J:139864
abnormal B cell number J:139864
decreased hematocrit J:139864
hemolytic anemia J:139864
increased anti-erythrocyte antigen antibody level J:139864
increased erythrocyte clearance J:139864

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory