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Targeted Allele Detail
Symbol: Igh-Jtm1Cgn
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, University of Cologne
MGI ID: MGI:1861941
Synonyms: Igh-JHdelta, JH-, JHT, Rr150-Jtm1Cgn
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:64285
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsDeletional recombination mediated by cre-loxP resulted in the loss of the exons encoding the joining region and the intron enhancer of the immunoglobulin heavy chain locus (IgH). (J:64285)
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Igh-Jtm1Cgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  12 strains or lines available
Original:  J:64285 Gu H, et al., Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993 Jun 18;73(6):1155-64
All:  77 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory