All Phenotypes Igh-J<tm1Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh-J^tm1Cgn
targeted mutation 1, University of Cologne
MGI:1861941

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-J^tm1Cgn/Igh-J^tm1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:2179193
ht2	Igh-J^tm1Cgn/Igh-J⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:2179194
cn3	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd	MGI:4430560
cn4	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430557
cn5	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430558
cn6	Gt(ROSA)26Sor^{tm9(Rac1,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,-EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430563
cn7	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430555
cn8	Gt(ROSA)26Sor^{tm8(Map2k1,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,-EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430561
cn9	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	Not Specified	MGI:3576498
cx10	Igh-J^tm1Cgn/Igh^tm11.1Cgn	involves: 129P2/OlaHsd	MGI:3687969
cx11	Igh-J^tm1Cgn/Igh^tm1Leck	involves: 129P2/OlaHsd * C57BL/6	MGI:3830847

Allelic Composition	Igh-J^tm1Cgn/Igh-J^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested B cell differentiation ( J:64285 )

• B cell development is blocked at the pre-B cell stage

absent mature B cells ( J:64285 )

• no mature B cells are formed

hematopoietic system

arrested B cell differentiation ( J:64285 )

• B cell development is blocked at the pre-B cell stage

absent mature B cells ( J:64285 )

• no mature B cells are formed

Allelic Composition	Igh-J^tm1Cgn/Igh-J⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:64285 )

• all B cells in the peripheral blood express only surface IgM^b while wild-type show equivalent numbers of IgM^a and IgM^b-bearing cells

• cultured splenic B cells stimulated with LPS and Il-4 show defective switch recombination at S_mu in cis (on mutant chromosome) compared to wild-type B cells

hematopoietic system

abnormal B cell differentiation ( J:64285 )

• all B cells in the peripheral blood express only surface IgM^b while wild-type show equivalent numbers of IgM^a and IgM^b-bearing cells

• cultured splenic B cells stimulated with LPS and Il-4 show defective switch recombination at S_mu in cis (on mutant chromosome) compared to wild-type B cells

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (34 available)
Foxo1^tm1Rdp mutation (2 available); any Foxo1 mutation (34 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (34 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Gt(ROSA)26Sor^{tm9(Rac1,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,-EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(Rac1*,-EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (1046 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Gt(ROSA)26Sor^{tm8(Map2k1,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,-EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm8(Map2k1*,-EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (45 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

immune system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

Allelic Composition	Igh-J^tm1Cgn/Igh^tm11.1Cgn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm11.1Cgn mutation (0 available); any Igh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:113434 )

• frequency of joints in mature B cells that have undergone by V_H replacement that contain the extra arginine that would be generated at the junction as well as the arginine encoded at the 3' end of the D23^stop allele is only 12%, indicating that counterselection of complementarity region 3s rich in positively charged amino acids occurs

• V_H replacement and direct V_H to D_H joining compete inefficiently with canonical VDJ recombination in B cell development in vivo in 2.5 month old mice

hematopoietic system

abnormal B cell differentiation ( J:113434 )

• V_H replacement and direct V_H to D_H joining compete inefficiently with canonical VDJ recombination in B cell development in vivo in 2.5 month old mice

Allelic Composition	Igh-J^tm1Cgn/Igh^tm1Leck
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm1Leck mutation (0 available); any Igh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immunoglobulin light chain V-J recombination ( J:144033 )

• the percentage of B cells expressing lambda light chain is about 4 times higher than in wild-type mice

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:144033 )

• the percentage of B cells expressing lambda light chain is about 4 times higher than in wild-type mice

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