Igh^tm3Tim
Targeted Allele Detail

Summary

• Symbol: Igh^tm3Tim
• Name: immunoglobulin heavy chain complex; targeted mutation 3, Tim Manser
• MGI ID: MGI:3609136
• Synonyms: HK171
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace J1 through J4 with a neomycin resistance cassette followed by the 36-65VDJ region with the following amino acid substitutions: A9V, Y32N, I51N, T58I, K59T, S77N, V100E, Y107K, with numbering from the mature amino terminus of the H chain. (J:102308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:102308 Heltemes-Harris L, et al., An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005 Nov;17(11):1447-61
• All: 1 reference(s)