Igk^{tm1(Igk564)Tik}
Targeted Allele Detail

Summary

• Symbol: Igk^{tm1(Igk564)Tik}
• Name: immunoglobulin kappa chain complex; targeted mutation 1, Thereza Imanishi-Kari
• MGI ID: MGI:3687307
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113555
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Igk^{tm1(Igk564)Tik} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igk (MGI:96494)

• Mutation details: A floxed neomycin resistance gene, as well as the 564 VkappaJkappa5 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including the entire J kappa region. Male chimeric mice were bred to C57BL/6 females. Offspring from these mice were crossed with cre expressing transgenic mice in order to excise the neomycin resistance cassette. (J:113555)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Igk^{tm1(Igk564)Tik}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 25 strains or lines available

References

• Original: J:113555 Berland R, et al., Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006 Sep;25(3):429-40
• All: 13 reference(s)