Igk Complex/Cluster/Region Detail

Summary

• Symbol
  Igk
• Name
  immunoglobulin kappa chain complex
• Synonyms
  kappa

• Feature Type
  complex/cluster/region
• IDs
  MGI:96494
  NCBI Gene: 243469

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, 30.89 cM, cytoband F1-pter
• Mapping Data
  44 experiments

Strain
Comparison

• PCR
  1
• RFLP
  3

Human Diseases

• Diseases
  1 with Igk mouse models

Human Disease

Mouse Models

renal tubular transport disease

IDs

renal tubular transport disease      

DOID:447
MESH:D015499
UMLS_CUI:C0035091

View 2 models

Mouse Models

Human Disease Modeled: renal tubular transport disease

Allelic Composition	Genetic Background	Reference	Phenotypes
Igktm1.1Cog/Igktm1.1Cog	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	J:135758	View
Igktm1.1Cog/Igktm1.2Cog	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	J:135758	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  4 with disease annotations

• References
  3 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 3 alleles in 3 genetic backgrounds
  68 phenotypes from multigenic genotypes
  171 phenotype references
  

• All Mutations and Alleles
  47
• Endonuclease-mediated
  3
• Targeted
  22
• Transgenic
  21
• Find Mice (IMSR)
  25 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal B cell number and differentiation.

Expression

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  3
• RefSeq
  1
• UniProt
  1

• NCBI Gene
  243469

Representative Sequences			Length	Strain/Species
transcript	AJ880391	GenBank | ENA | DDBJ | MGI Sequence Detail	333	Not Specified
polypeptide	Q5F2I7	UniProt | EBI | MGI Sequence Detail	111	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR013106 Immunoglobulin V-set domain

Molecular
Reagents

• All nucleic 11

  Genomic 6

  cDNA 2

  Primer pair 1

  Other 2

Other
Accession IDs

MGD-MRK-11292

References

• Summaries
  All 294

  Diseases 3

  Phenotypes 171
• Earliest
  J:6050 Hengartner H, et al., Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4494-8
• Latest
  J:333805 Schiepers A, et al., Molecular fate-mapping of serum antibody responses to repeat immunization. Nature. 2023 Jan 16;