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Igk Complex/Cluster/Region Detail
Summary
  • Symbol
    Igk
  • Name
    immunoglobulin kappa chain complex
  • Synonyms
    kappa
Location &
Maps
more
  • Sequence Map
    Chr6:67532620-70703738 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.89 cM, cytoband F1-pter
  • Mapping Data
    44 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99669 from dbSNP Build 142
  • PCR
    1
  • RFLP
    3
Human Diseases
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  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    68 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B cell number and differentiation.
Expression
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  • Other Mouse Links
    GEO
Sequences &
Gene Models
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  • All Sequences
    4
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 243469 NCBI Gene Model | MGI Sequence Detail 3171119 C57BL/6J ±  kb
transcript AJ880391 GenBank | ENA | DDBJ | MGI Sequence Detail 333 Not Specified  
polypeptide Q5F2I7 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR050150 Immunoglobulin Variable Light Chain
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 11
    Genomic 6
    cDNA 2
    Primer pair 1
    Other 2
Other
Accession IDs
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MGD-MRK-11292
References
more
  • Summaries
    All 323
    Diseases 3
    Phenotypes 196
  • Earliest
    J:6050 Hengartner H, et al., Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4494-8
  • Latest
    J:371307 Zuo T, et al., Somatic hypermutation generates antibody specificities beyond the primary repertoire. Immunity. 2025 Jun 10;58(6):1396-1410.e7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/09/2025
MGI 6.24 		The Jackson Laboratory