About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igk
immunoglobulin kappa chain complex
MGI:96494
67 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Atp11cm1Btlr/Y
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0
involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu 		decreased B cell number J:171925
Blnktm1Kplm/Blnktm1Kplm
Ightm4Cgn/Igh+
Igktm1Rsky/Igk+
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:120460
decreased B cell number J:120460
increased pre-B cell number J:120460
increased transitional stage B cell number J:120460
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
NOD.Cg-Emv30b Prkdcscid Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs 		normal homeostasis/metabolism phenotype J:274578
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Igh+
Igktm1Jiac/Igktm1Jiac
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		decreased mature B cell number J:133032
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igk+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		decreased mature B cell number J:133032
Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igktm1Jiac
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal B cell physiology J:133032
abnormal B cell selection J:133032
decreased mature B cell number J:133032
Gpr183tm1.2Rbr/Gpr183tm1.2Rbr
Ightm1Rbr/Ightm1Rbr
Tg(IgkHyHEL10)1Rbr/0
involves: C57BL/6 * FVB/N * SJL 		abnormal B cell physiology J:151883
abnormal B cell proliferation J:151883
decreased B cell number J:151883
decreased IgG1 level J:151883
decreased IgM level J:151883
decreased plasma cell number J:151883
Igh-Jtm1Dhu/Igh-Jtm1(VDJ-17.2.25)Wabl
Igktm1Dhu/Igktm1Dhu
Not Specified 		abnormal B cell differentiation J:33628
abnormal immature B cell morphology J:89757
Ightm1(IGH)Vlcg/Ightm1(IGH)Vlcg
Igktm1(IGK)Vlcg/Igktm1(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N 		normal immune system phenotype J:208620
reduced male fertility J:208619
Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
Igktm1.1(b12)Nemz/Igktm1.1(b12)Nemz
involves: C57BL/6N * C57BL/6NTac * FVB/N 		decreased IgM level J:205766
decreased immature B cell number J:205766
normal immune system phenotype J:205766
increased B cell number J:205766
Ightm1.1(Igh564)Tik/Ightm1.1(Igh564)Tik
Igktm1(Igk564)Tik/Igktm1(Igk564)Tik
B6.129S4-Igktm1(Igk564)Tik Ightm1(Igh564)Tik 		abnormal glomerular mesangium morphology J:113555
abnormal podocyte morphology J:113555
expanded mesangial matrix J:113555
glomerulonephritis J:113555
increased mesangial cell number J:113555
podocyte foot process effacement J:113555
Ightm1Cys/Igh+
Tg(Igk)5Cys/0
B6.Cg-Ightm1Cys Tg(Igk)5Cys 		abnormal B cell physiology J:118931
normal immune system phenotype J:118931
Ightm1Cys/Igh+
Tg(Igk)5Cys/0
Tg(UBC-GFP)30Scha/Tg(UBC-GFP)30Scha
involves: 129X1/SvJ * C57BL/6 * CBA 		normal immune system phenotype J:118931
Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0
involves: C57BL/6 * SJL 		increased B cell number J:115292
Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		increased B cell number J:115292
Ightm1Ktom/Ightm1Ktom
Igktm1Ktom/Igktm1Ktom
Tc(HSA14)SC20Ktom/0
Tc(HSA2)W23Ktom/0
involves: C57BL/6NCrlj * CBA/JNCrlj * ICR 		abnormal B cell physiology J:59894
Ightm1Rbr/Igh+
Tg(IgkHyHEL10)1Rbr/0
involves: C57BL/6 		abnormal B cell morphology J:132538
abnormal B-2 B cell morphology J:132538
increased IgA level J:132538
increased IgG1 level J:132538
increased IgG2a level J:132538
increased IgG2b level J:132538
increased IgG3 level J:132538
increased IgM level J:132538
increased immature B cell number J:132538
increased immunoglobulin level J:132538
Ightm1Rbr/Igh+
Tg(IgkHyHEL10)1Rbr/0
Tg(ML5sHEL)5Ccg/0
involves: C57BL/6 * C57BL/6JSfd 		abnormal B cell anergy J:132538
abnormal B cell morphology J:132538
decreased follicular B cell number J:132538
decreased marginal zone B cell number J:132538
increased immature B cell number J:132538
Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Igktm2(IGK)Vlcg/Igktm2(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N 		normal immune system phenotype J:208620
reduced male fertility J:208619
Ightm2.1(4E10)Nemz/Ightm2.1(4E10)Nemz
Igktm2.1(4E10)Nemz/Igktm2.1(4E10)Nemz
involves: C57BL/6 * C57BL/6N * C57BL/6NTac * FVB/N 		decreased B cell number J:101977
decreased IgG level J:101977
decreased IgM level J:101977
Ightm2Cgn/Igh+
Igktm1Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) 		abnormal B cell differentiation J:111431
absent pre-B cells J:111431
Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
involves: 129P2/OlaHsd 		abnormal class switch recombination J:150435
Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Prkdcscid/Prkdcscid
involves: 129P2/OlaHsd * BALB/c * C57BL/Ka 		abnormal class switch recombination J:150435
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal class switch recombination J:126758
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
Ightm2Rsky/Igh+
Igktm1Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) 		abnormal B cell differentiation J:111431
Ightm2Rsky/Igh+
Igktm2Rsky/Igk+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) 		abnormal B cell differentiation J:111431
Ightm3.1(IGH)Vlcg/Ightm3.1(IGH)Vlcg
Igktm3.1(IGK)Vlcg/Igktm3.1(IGK)Vlcg
involves: 129S6/SvEvTac * C57BL/6N 		normal immune system phenotype J:208620
reduced male fertility J:208619
Igk-Jtm1Mwg/Igktm1Dhu
involves: 129S7/SvEvBrd * C57BL/6 		normal immune system phenotype J:76116
Igk-Jtm2Mwg/Igktm1Dhu
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		normal immune system phenotype J:76116
Igktm1.1(b12)Nemz/Igktm1.1(b12)Nemz
involves: C57BL/6NTac * FVB/N 		normal immune system phenotype J:205766
Igktm1.1Cog/Igktm1.1Cog
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal proximal convoluted tubule morphology J:135758
decreased blood uric acid level J:135758
decreased circulating phosphate level J:135758
increased urine phosphate level J:135758
increased urine protein level J:135758
increased urine uric acid level J:135758
proximal convoluted tubule brush border loss J:135758
Igktm1.1Cog/Igktm1.1Cog
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N 		abnormal proximal convoluted tubule morphology J:135758
Igktm1.1Cog/Igktm1.2Cog
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal proximal convoluted tubule morphology J:135758
decreased blood uric acid level J:135758
Igktm1.1Cog/Igktm1.2Cog
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N 		normal renal/urinary system phenotype J:135758
Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		decreased B cell number J:68144
Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1tm1.1Ust
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		decreased B cell number J:68144
Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal B cell differentiation J:68144
increased B cell number J:68144
Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1tm1Ust
involves: 129S7/SvEvBrd * C57BL/6 		increased B cell number J:68144
Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust
involves: 129S7/SvEvBrd 		increased B-1a cell number J:113218
Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal B cell differentiation J:74717
decreased B cell number J:74717
decreased immature B cell number J:74717
decreased marginal zone B cell number J:74717
decreased mature B cell number J:74717
decreased transitional stage T1 B cell number J:74717
decreased transitional stage T2 B cell number J:74717
Igktm1Dhu/Igktm1Dhu
Tg(H2-Ea-HA)HACIIAjca/0
Tg(Tcra/Tcrb)1Vbo/0
C.Cg-Igktm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo 		arthritis J:209872
Igktm1Dhu/Igktm1Dhu
Tg(H2-Ea-HA)HACIIAjca/0
Tg(TcraS106-1,TcrbS106-1)TS1SWAjca/0
C.Cg-Igktm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(TcraS106-1,TcrbS106-1)TS1SWAjca 		abnormal CD4-positive, alpha beta T cell morphology J:209872
abnormal lymph node morphology J:209872
abnormal spleen morphology J:209872
absent B cells J:209872
decreased susceptibility to autoimmune disorder J:209872
increased CD4-positive, alpha-beta T cell number J:209872
Igktm1Rsky/Igk+
Igll1tm1Cgn/Igll1tm1Cgn
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 		abnormal B cell differentiation J:35357
decreased B cell number J:35357
decreased immature B cell number J:35357
decreased mature B cell number J:35357
decreased pre-B cell number J:35357
Igktm2Ybgn/Igktm2Ybgn
Not Specified 		decreased pre-B cell number J:123344
increased immature B cell number J:123344
Igll1tm1Cgn/Igll1tm1Cgn
Tg(Igk-V4CH27)1-2Shc/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL 		abnormal B cell differentiation J:35357
decreased pre-B cell number J:35357
Tg(IghH280)48Dvs/?
Tg(IgkH280)934Dvs/?
NOD/ShiLtDvs-Tg(IghH280)48Dvs Tg(IgkH280)934Dvs/Dvs 		increased susceptibility to autoimmune diabetes J:274578
Tg(SV40-Igh-64C8)H3Hon/0
Tg(SV40-Igk4C8)L1Hon/0
involves: C57BL/6 		abnormal B cell clonal deletion J:139864
abnormal B cell number J:139864
decreased hematocrit J:139864
hemolytic anemia J:139864
increased anti-erythrocyte antigen antibody level J:139864
increased erythrocyte clearance J:139864
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory