Tg(TcraS106-1,TcrbS106-1)TS1SWAjca
Transgene Detail

Summary

• Symbol: Tg(TcraS106-1,TcrbS106-1)TS1SWAjca
• Name: transgene insertion TS1SW, Andrew J Caton
• MGI ID: MGI:5903429
• Synonyms: TS1(SW)
• Transgene: Tg(TcraS106-1,TcrbS106-1)TS1SWAjca Location: unknown
• Alliance: Tg(TcraS106-1,TcrbS106-1)TS1SWAjca page

Transgene origin

• Strain of Origin: C57BL/6 x BALB/c

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct expresses a T cell receptor raised against hemagglutinin (HA) from influenza virus A/SW/33(SW), which contains an analog of the S1 determinant that differs from S1 by 2 substitutions, R to K at residue 113 and E to T at residue 120, isolated from hybridoma S106-1. This receptor is encoded by TCR Valpha8.3 and Vbeta10, and has a much lower affinity for the original S1 determinant than does Tg(Tcra/Tcrb)1Vbo . (J:133154)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:133154 Jordan MS, et al., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2001 Apr;2(4):301-6
• All: 5 reference(s)