Igh-J^tm1Dhu
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Dhu
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Dennis Huszar
• MGI ID: MGI:2158307
• Synonyms: Jh^-, J^H, JH⁰, JHD, JHT
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52448
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A ~2.3 kb genomic fragment encompassing the four J-H segments and a flanking D-Q52 segment was replaced with a neomycin selection cassette. Homozygous mice do not produce rearranged immunoglobulin heavy chains. (J:52448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

Notes

Homozygous mutant mice do not develop mature B cells (J:97700).

References

• Original: J:52448 Chen J, et al., Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol. 1993 Jun;5(6):647-56
• All: 131 reference(s)