Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation
(1 available);
any
Igh-J mutation
(13 available)
Ightm3Tim mutation
(0 available);
any
Igh mutation
(43 available)
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hematopoietic system
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• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
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• B cell in mutants are reduced in the spleen, bone marrow and LNs
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immune system
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• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
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• B cell in mutants are reduced in the spleen, bone marrow and LNs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation
(1 available);
any
Igh-J mutation
(13 available)
Wdr1rede mutation
(0 available);
any
Wdr1 mutation
(41 available)
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immune system
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• the phenotype is similar to mice that are homozygote only for the Wdr1rede allele indicating that the inflammatory lesions are not the result of B-cells activity
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hematopoietic system
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• three week old mice have about 5-fold less platelets per liter of blood compared to wild-type littermates
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immune system
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• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
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• are increased 3-10 fold in size as compared to control littermates
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digestive/alimentary system
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• loss of mucin is observed in goblet cells
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• crypt hyperplasia and unusual branching is observed
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• occasional occurrence among mice whom live past 9 weeks of age
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• occurs in mice 24 weeks of age
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• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
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cardiovascular system
growth/size/body
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• weight loss resulting from intestinal inflammation is observed by 24 weeks
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hematopoietic system
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• : hemocrit levels are near normal (36% mean), suggesting B cells contribute to the anemia observed in mice lacking IL2 expression
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behavior/neurological
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• occurs in mice 24 weeks of age
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cellular
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• loss of mucin is observed in goblet cells
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immune system
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• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
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• are increased 3-10 fold in size as compared to control littermates
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digestive/alimentary system
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• loss of mucin is observed in goblet cells
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• crypt hyperplasia and unusual branching is observed
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• occasional occurrence among mice whom live past 9 weeks of age
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• occurs in mice 24 weeks of age
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• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
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cardiovascular system
growth/size/body
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• weight loss resulting from intestinal inflammation is observed by 24 weeks
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hematopoietic system
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• occurs in mice 24 weeks of age
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behavior/neurological
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• occurs in mice 24 weeks of age
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cellular
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• loss of mucin is observed in goblet cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation
(1 available);
any
Igh-J mutation
(13 available)
Ightm2Tim mutation
(0 available);
any
Igh mutation
(43 available)
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hematopoietic system
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• cell surface IgM levels are somewhat lower in B220+ and E4+ cells
• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced
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immune system
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• cell surface IgM levels are somewhat lower in B220+ and E4+ cells
• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced
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• cell surface IgD levels as in the spleen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation
(1 available);
any
Igh-J mutation
(13 available)
Ightm1Tim mutation
(0 available);
any
Igh mutation
(43 available)
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hematopoietic system
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• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
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• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
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• B cell area decreased in size
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immune system
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• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
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• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
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• B cell area decreased in size
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hematopoietic system
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• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2
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• 80% of bone marrow B cells have an immature phenotype
• rapid turnover
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immune system
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• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2
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• 80% of bone marrow B cells have an immature phenotype
• rapid turnover
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Analysis Tools