Wdr1^rede
Chemically induced Allele Detail

Summary

• Symbol: Wdr1^rede
• Name: WD repeat domain 1; red ears
• MGI ID: MGI:2671870
• Synonyms: redears, rede^m01Jus, Wdr1^rd
• Gene: Wdr1 Location: Chr5:38684149-38720265 bp, - strand Genetic Position: Chr5, 20.63 cM
• Alliance: Wdr1^rede page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion is a T-to-A transversion mutation in the second dinucleotide of the intron 9 splice donor. Splicing of the normal trancript is reduced to 20-30% and an aberrant transcript using a cryptic site is expressed. While a small amount of wild-type protein is expressed, the aberrent transcript is predicted to express a mutant protein that lacks 2 amino acids from the sixth WD40 repeat. This mutation is hypomorphic. (J:134092)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr1 Mutation: 41 strains or lines available

References

• Original: J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
• All: 6 reference(s)