Igk^tm2Ybgn
Targeted Allele Detail

Summary

• Symbol: Igk^tm2Ybgn
• Name: immunoglobulin kappa chain complex; targeted mutation 2, Yehudit Bergman
• MGI ID: MGI:3720251
• Synonyms: D23kappai, D23mCkappa
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to contain the pre-rearranged D23VkJk5 sequence driven by its endogenous promoter. A loxP site flanked neomycin resistance gene cassette was removed through cre-mediated recombination. (J:123344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 25 strains or lines available

References

• Original: J:123344 Fraenkel S, et al., Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul;8(7):715-22
• All: 2 reference(s)