Igh^{tm1.1(Igh564)Tik}
Targeted Allele Detail

Summary

• Symbol: Igh^{tm1.1(Igh564)Tik}
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Thereza Imanishi-Kari
• MGI ID: MGI:3687305
• Synonyms: IgH564
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113555
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Igh^{tm1.1(Igh564)Tik} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh (MGI:96442)

• Mutation details: A floxed neomycin resistance gene, as well as the VDJ 564 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including DQ52 and the entire JH region. Male chimeric mice were bred to C57BL/6 females. The resulting offspring were crossed with cre expressing transgenic mice in order to excise the neomycin resistance cassette. (personal communication)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Igh^{tm1.1(Igh564)Tik}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:113555 Berland R, et al., Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006 Sep;25(3):429-40
• All: 13 reference(s)