Igh^{tm1.1(Rr361-HBB)Aak}
Targeted Allele Detail

Summary

• Symbol: Igh^{tm1.1(Rr361-HBB)Aak}
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Ahmed Khamlichi
• MGI ID: MGI:7435233
• Synonyms: 2Ialpha
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242276
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Igh^{tm1.1(Rr361-HBB)Aak} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBB (3043)

  Hbb-b1	(MGI:96021)
  Hbb-b2	(MGI:96022)
  Hbb-bh2	(MGI:96025)
  Hbb-bs	(MGI:5474852)
  Hbb-bt	(MGI:5474850)

• Mutation details: Igha promoter Rr361 (~840 bp), (part of) the last intron and exon of human hemoglobin subunit beta (~1100 bp) and a loxP site flanked neomycin resistance gene cassette were inserted downstream of super-enhancer 3'RR (Rr152), between it and Igh super-insulator Rr363. The neo cassette was removed through subsequent cre-mediated recombination. (J:242276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 45 strains or lines available

References

• Original: J:242276 Braikia FZ, et al., Inducible CTCF insulator delays the IgH 3' regulatory region-mediated activation of germline promoters and alters class switching. Proc Natl Acad Sci U S A. 2017 Jun 06;114(23):6092-6097
• All: 2 reference(s)