Lyn^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Lyn^tm1Sor
• Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1861966
• Synonyms: Lyn-
• Gene: Lyn Location: Chr4:3676865-3791612 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^tm1Sor page

Lupus-like autoimmune disease in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Top2a^{Gt(PST14568)Mfgc}/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42037
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3 - 7 of the gene. No transcript for the targeted gene was detected on Northern blots from homozygous mutant mouse bone marrow cells. (J:42037, J:102647)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 64 strains or lines available

References

• Original: J:42037 Chan VW, et al., Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul;7(1):69-81
• All: 137 reference(s)