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Ighmtm1Cgn
Targeted Allele Detail
Summary
Symbol: Ighmtm1Cgn
Name: immunoglobulin heavy constant mu; targeted mutation 1, University of Cologne
MGI ID: MGI:1857187
Synonyms: B cell-, BCKO, BCR-, BKO, Cmu -, Ig-, IgH-, Igh-6-, Igh-6null, Igh-6tm1Cgn, Igh-6tm1CgnmuMT0, Ighm-, IgHmuMT, Ig- muMT, Igmunull, muIgKO, mum-, muMt-, muMT, mu-MT-
Gene: Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance: Ighmtm1Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70398
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). (J:70398, J:110548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ighmtm1Cgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 17 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:  55 strains or lines available
References
Original:  J:70398 Kitamura D, et al., A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991 Apr 4;350(6317):423-6
All:  833 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory