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Ctnnb1
Gene Detail
Symbol

Name
ID
Ctnnb1
catenin (cadherin associated protein), beta 1
MGI:88276
Synonyms
beta catenin, beta-catenin, Bfc, Catnb
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:120929216-120960507 bp, + strand
From VEGA annotation of GRCm38

  31292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: beta-catenin/plakoglobin
Gene Tree: Ctnnb1
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(22)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.
 
Human Diseases Modeled Using Mouse Ctnnb1 (6)    Alleles Annotated to Human Diseases(3)    Phenotype Images(3)
Interactions
Ctnnb1 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (263 annotations)
Process adherens junction assembly, adherens junction organization, ...
Component adherens junction, apical junction complex, ...
Function alpha-catenin binding, cadherin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (614 records)
Data Summary: Results (749)    Tissues (405)    Images (167)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 177
RNA in situ 360
In situ reporter (knock in) 3
Northern blot 10
Western blot 40
RT-PCR 159
cDNA source data(971)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(987) cDNA(974) Primer pair(12) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016490 (Evidence)
Ensembl Gene ModelENSMUSG00000006932 (Evidence)
Entrez Gene12387, 102637827
UniGene291928
PDB1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 2BCT, 3BCT, 3OUW, 3OUX, 4EVA, 4EVP, 4EVT, 4ONS, 1V18, 4EV8, 4EV9
Consensus CDS ProjectCCDS23630.1
International Mouse Knockout Project StatusCtnnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
transcript OTTMUST00000039790 VEGA | MGI Sequence Detail 3623 Not Applicable 
polypeptide OTTMUSP00000017750 VEGA | MGI Sequence Detail 781 Not Applicable 

For the selected sequences
All sequences(80) UniProt(19)
Polymorphisms
PCR(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR013284 Beta-catenin
Protein Ontology PR:000002198 catenin beta-1
References
(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:215012 Boerboom D, et al., beta-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo. Endocrinology. 2014 Oct 24;:en20141296
All references(1205)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1775, MGI:2656732

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory