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Ctnnb1
Gene Detail
 Symbol
Name
ID
Ctnnb1
catenin (cadherin associated protein), beta 1
MGI:88276
Synonyms beta catenin, beta-catenin, Bfc, Catnb
Feature Type protein coding gene
Genetic Map
Chromosome 9
72.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:120929216-120960507 bp, + strand
From VEGA annotation of GRCm38

  31292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1434  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: beta-catenin/plakoglobin
Gene Tree: Ctnnb1

Human
homologs
Human Homolog CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Gene ID 1499
neXtProt AC  NX_P35222
Human Synonyms  armadillo, CTNNB, MRD19
Human Chr (Location)  3p21; chr3:41199451-41240448 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human CTNNB1
Alleles
and
phenotypes
All alleles(35) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(22)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.
 
Human Diseases Modeled Using Mouse Ctnnb1 (5)    Alleles Annotated to Human Diseases(3)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (334 annotations)
Process adherens junction assembly, anterior/posterior axis specification, ...
Component adherens junction, apical junction complex, ...
Function alpha-catenin binding, cadherin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (583 records)
Data Summary: Results (751)    Tissues (400)    Images (160)
Theiler Stages: 1, 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 174
RNA in situ 360
In situ reporter (knock in) 3
Northern blot 10
Western blot 36
RT-PCR 168
cDNA source data(971)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(986) cDNA(974) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016490 (Evidence)
Ensembl Gene ModelENSMUSG00000006932 (Evidence)
Entrez Gene12387 (Evidence)
UniGene291928
PDB1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 2BCT, 3BCT, 3OUW, 3OUX, 4EVA, 4EVP, 4EVT, 4ONS, 1V18, 4EV8, 4EV9
Consensus CDS ProjectCCDS23630.1
International Mouse Knockout Project StatusCtnnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
transcript OTTMUST00000039790 VEGA | MGI Sequence Detail 3623 Not Applicable 
polypeptide OTTMUSP00000017750 VEGA | MGI Sequence Detail 781 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(6) UniProt(11)
Polymorphisms PCR(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR013284 Beta-catenin
Protein Ontology PR:000002198 catenin beta-1
References (Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:210472 Zito G, et al., Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nat Commun. 2014;5:3543
All references(1153)
Other
accession IDs
MGD-MRK-1775, MGI:2656732

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory