About   Help   FAQ
Gene Detail
catenin (cadherin associated protein), beta 1
Synonyms beta catenin, beta-catenin, Bfc, Catnb
Feature Type protein coding gene
Genetic Map
Chromosome 9
72.19 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr9:120929216-120960507 bp, + strand
From VEGA annotation of GRCm38

  31292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1434  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: beta-catenin/plakoglobin
Gene Tree: Ctnnb1

Human Homolog CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Gene ID 1499
neXtProt AC  NX_P35222
Human Synonyms  armadillo, CTNNB, MRD19
Human Chr (Location)  3p21; chr3:41199451-41240448 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human CTNNB1
alleles, and
All mutations/alleles(35) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(22)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.
Human Diseases Modeled Using Mouse Ctnnb1 (6)    Alleles Annotated to Human Diseases(3)    Phenotype Images(3)
Ctnnb1 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
All GO classifications: (339 annotations)
Process adherens junction assembly, adherens junction organization, ...
Component adherens junction, apical junction complex, ...
Function alpha-catenin binding, cadherin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (586 records)
Data Summary: Results (740)    Tissues (402)    Images (160)
Theiler Stages: 1, 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 174
RNA in situ 360
In situ reporter (knock in) 3
Northern blot 10
Western blot 36
RT-PCR 157
cDNA source data(971)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(986) cDNA(974) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000016490 (Evidence)
Ensembl Gene ModelENSMUSG00000006932 (Evidence)
Entrez Gene12387 (Evidence)
PDB1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 2BCT, 3BCT, 3OUW, 3OUX, 4EVA, 4EVP, 4EVT, 4ONS, 1V18, 4EV8, 4EV9
Consensus CDS ProjectCCDS23630.1
International Mouse Knockout Project StatusCtnnb1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
transcript OTTMUST00000039790 VEGA | MGI Sequence Detail 3623 Not Applicable 
polypeptide OTTMUSP00000017750 VEGA | MGI Sequence Detail 781 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(6) UniProt(11)
Polymorphisms PCR(1) : SNPs within 2kb(62 from dbSNP Build 137)
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR013284 Beta-catenin
Protein Ontology PR:000002198 catenin beta-1
References (Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:212597 Ordonez-Moran P, et al., SPROUTY2 is a beta-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. Oncogene. 2014 Apr 10;33(15):1975-85
All references(1169)
Disease annotation references (3)
accession IDs
MGD-MRK-1775, MGI:2656732

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory