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Ctnnb1 Gene Detail
Summary
  • Symbol
    Ctnnb1
  • Name
    catenin (cadherin associated protein), beta 1
  • Synonyms
    beta catenin, beta-catenin, Bfc, Catnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88276
    NCBI Gene: 12387
  • Gene Overview
    MyGene.info: CTNNB1
Location & Maps
more
  • Sequence Map
    Chr9:120929216-120960507 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31292 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTNNB1, catenin beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    armadillo, CTNNB, MRD19
  • Links
    NCBI Gene ID: 1499
    neXtProt AC: NX_P35222

  • Chr Location
    3p22.1; chr3:41199451-41240448 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Ctnnb1 mouse models; 5 with human CTNNB1 associations

Human Disease Mouse Models
       Ovarian Cancer   OMIM: 167000 View 6 models
       Bladder Cancer   OMIM: 109800 View 4 models
Prostate Cancer   OMIM: 176807 View 1 model
       Colorectal Cancer; CRC   OMIM: 114500
Hepatocellular Carcinoma   OMIM: 114550
Mental Retardation, Autosomal Dominant 19; MRD19   OMIM: 615075
Pilomatrixoma   OMIM: 132600
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    329 phenotypes from 16 alleles in 55 genetic backgrounds
    249 phenotypes from multigenic genotypes
    4 images
    629 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Chemically induced (ENU)
    1
  • Gene trapped
    12
  • Targeted
    30
  • Transgenic
    5
  • Incidental Mutations
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
transcript OTTMUST00000039790 VEGA | MGI Sequence Detail 3623 Not Applicable  
polypeptide OTTMUSP00000017750 VEGA | MGI Sequence Detail 781 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 991
    cDNA 976
    Primer pair 14
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1775, MGI:2656732
References
more
  • Summaries
    All 1416
    Developmental Gene Expression 722
    Diseases 8
    Gene Ontology 219
    Phenotypes 629
  • Earliest
    J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
  • Latest
    J:236848 Chen Q, et al., Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun. 2016 Aug 12;7:12422

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory