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Ctnnb1 Gene Detail
Summary
  • Symbol
    Ctnnb1
  • Name
    catenin (cadherin associated protein), beta 1
  • Synonyms
    beta catenin, beta-catenin, Bfc, Catnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88276
    NCBI Gene: 12387
  • Gene Overview
    MyGene.info: CTNNB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:120929216-120960507 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31292 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTNNB1, catenin beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    armadillo, CTNNB, EVR7, MRD19
  • Links
    NCBI Gene ID: 1499
    neXtProt AC: NX_P35222
    UniProt: P35222

  • Chr Location
    3p22.1; chr3:41199451-41240448 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with Ctnnb1 mouse models; 7 with human CTNNB1 associations

Human Disease Mouse Models
      
IDs
View 6 models
      
IDs
View 1 model
IDs
View 6 models
IDs
View 1 model
IDs
View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    348 phenotypes from 16 alleles in 57 genetic backgrounds
    251 phenotypes from multigenic genotypes
    6 images
    723 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
    transcript OTTMUST00000039790 VEGA | MGI Sequence Detail 3623 Not Applicable  
    polypeptide OTTMUSP00000017750 VEGA | MGI Sequence Detail 781 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      62 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 994
      cDNA 977
      Primer pair 15
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1775, MGI:2656732
    References
    more
    • Summaries
      All 1846
      Developmental Gene Expression 833
      Diseases 12
      Gene Ontology 226
      Phenotypes 723
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:263559 Yun K, et al., Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression. PLoS One. 2018;13(5):e0197356

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory