Ctnnb1
Gene Detail

Symbol Name ID

Ctnnb1 catenin (cadherin associated protein), beta 1 MGI:88276

Synonyms

beta catenin, beta-catenin, Bfc, Catnb

Feature Type

protein coding gene

Genetic Map

Chromosome 9

72.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:120929216-120960507 bp, + strand From VEGA annotation of GRCm38   31292 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1434  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: beta-catenin/plakoglobin
Gene Tree: Ctnnb1

Human homologs

Human Homolog		CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Gene ID		1499
neXtProt AC		NX_P35222
Human Synonyms		armadillo, CTNNB, MRD19
Human Chr (Location)		3p21; chr3:41240942-41281939 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human CTNNB1

Alleles and phenotypes

All alleles(35) : Targeted(22) Gene trapped(12) Chemically induced(1)
 

Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc.

 
Human Diseases Modeled Using Mouse Ctnnb1 (4)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (317 annotations)

Process	adherens junction assembly, anterior/posterior axis specification, ...
Component	adherens junction, apical junction complex, ...
Function	alpha-catenin binding, cadherin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (533 records)
Data Summary: Results (700)    Tissues (382)    Images (119)
Theiler Stages: 1, 2, 3, 4, 5, 9, 11, 12, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	123
RNA in situ	360
In situ reporter (knock in)	3
Northern blot	10
Western blot	36
RT-PCR	168

cDNA source data(961)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(976) cDNA(964) Primer pair(11) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016490 (Evidence)
Ensembl Gene Model	ENSMUSG00000006932 (Evidence)
Entrez Gene	12387 (Evidence)
UniGene	291928
DFCI	TC1573680, TC1649267
DoTS	DT.101138386, DT.101399058, DT.101399074, DT.102541092, DT.496455, DT.55189223, DT.94216387, DT.97365184, DT.97380877
NIA Mouse Gene Index	U011162
PDB	1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 2BCT, 3BCT, 3OUW, 3OUX, 1V18
Consensus CDS Project	CCDS23630.1
International Mouse Knockout Project Status	Ctnnb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016490	VEGA Gene Model | MGI Sequence Detail	31292	C57BL/6J
transcript	OTTMUST00000039790	VEGA | MGI Sequence Detail	3623	Not Applicable
polypeptide	OTTMUSP00000017750	VEGA | MGI Sequence Detail	781	Not Applicable

All sequences(123) RefSeq(4) UniProt(11)

Polymorphisms

PCR(1) : SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000225	Armadillo
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR013284	Beta-catenin
Protein Ontology	PR:000002198	catenin beta-1

References

(Earliest) J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
(Latest) J:195205 Albers J, et al., Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin. J Cell Biol. 2013 Feb 18;200(4):537-49
All references(1025)

Other accession IDs

MGD-MRK-1775, MGI:2656732