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Phenotypes Associated with This Genotype
Genotype
MGI:5432231
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (51 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 12-14 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

reproductive system
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 12-14 weeks of age
seminiferous tubule degeneration ( J:186144 )
• seminiferous tubule degeneration is seen by 4 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:186144 )
• female mutants develop granulosa cell tumors by 12-14 weeks of age
seminiferous tubule degeneration ( J:186144 )
• seminiferous tubule degeneration is seen by 4 weeks of age
increased testis tumor incidence ( J:186144 )
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory