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Phenotypes Associated with This Genotype
Genotype
MGI:5432224
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within 3.5-5.5 months of age

neoplasm
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

reproductive system
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

homeostasis/metabolism
• at 6 weeks of age in females
• at 6 weeks of age in females
• at 6 weeks of age in females

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:186144
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory