About   Help   FAQ
Transgene Detail
Symbol: Tg(Msx2-rtTA)885Lma
Name: transgene insertion 885, Liang Ma
MGI ID: MGI:5546503
Transgene: Tg(Msx2-rtTA)885Lma  Location: unknown  
Alliance: Tg(Msx2-rtTA)885Lma page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThis transgene consists of a 187 kb BAC clone, RP24-512K19, containing the endogenous Msx2 locus and flanking sequences (134 kb upstream and 47 kb downstream of Msx2; accession number AC154808) and a modified rtTA gene that replaced part of the first exon right after the start codon, followed by a FRT-flanked neomycin cassette and polyA sequences and was made using a two-step recombineering strategy. Two founding lines were established, 885 and 888. Western blot analysis failed to detect any truncated or fusion Msx2 protein. This BAC clone contains six additional predicted genes, which may be overexpressed. (J:148502)
Generation of the Tg(Msx2-rtTA)888Lma and Tg(Msx2-rtTA)885Lma transgenes
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Tg(Msx2-rtTA)885Lma
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:148502 Lin C, et al., Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis. 2009 Apr 15;47(5):352-359
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory