Analysis Tools
neoplasm
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• presence of nests of dysplastic cells are seen in the ovaries of newborn mice and E20.5, but not E18.5, indicating that tumor growth begins perinatally
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• females develop ovarian granulosa cell bilateral tumors with 100% penetrance from an early age
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• 100% penetrance of aggressive testicular cancer
• tumors are first observable at 5 weeks of age, and by 3 months of age, about 70% of mice have unilateral testicular tumors and 30% have bilateral tumors
• tumors exhibit characteristics of granulosa cell tumors of the testis and not Sertoli cell tumors
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• metastasis is not observed, but this might be that mice do not have sufficient time to develop metastasis due to early lethality, however, when granulosa cell tumors are removed at 6 weeks of age, mice show development of large lung metastases 6-16 weeks later, indicating that tumors indeed are metastatic
(J:142150)
• 44% of mice develop pulmonary metastases by 4 months
(J:149060)
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reproductive system
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• seminiferous tubule degeneration is seen by 3 weeks of age
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• presence of nests of dysplastic cells are seen in the ovaries of newborn mice and E20.5, but not E18.5, indicating that tumor growth begins perinatally
|
|
• females develop ovarian granulosa cell bilateral tumors with 100% penetrance from an early age
|
|
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• 100% penetrance of aggressive testicular cancer
• tumors are first observable at 5 weeks of age, and by 3 months of age, about 70% of mice have unilateral testicular tumors and 30% have bilateral tumors
• tumors exhibit characteristics of granulosa cell tumors of the testis and not Sertoli cell tumors
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endocrine/exocrine glands
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• seminiferous tubule degeneration is seen by 3 weeks of age
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• presence of nests of dysplastic cells are seen in the ovaries of newborn mice and E20.5, but not E18.5, indicating that tumor growth begins perinatally
|
|
• females develop ovarian granulosa cell bilateral tumors with 100% penetrance from an early age
|
|
|
• 100% penetrance of aggressive testicular cancer
• tumors are first observable at 5 weeks of age, and by 3 months of age, about 70% of mice have unilateral testicular tumors and 30% have bilateral tumors
• tumors exhibit characteristics of granulosa cell tumors of the testis and not Sertoli cell tumors
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cardiovascular system
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• pulmonary tumor cell embolisms
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hematopoietic system
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• extrensive extramedullary hematopoiesis
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mortality/aging
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• female mice die before 9 weeks of age
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respiratory system
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• pulmonary tumor cell embolisms
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| granulosa cell tumor | DOID:2999 | J:142150 | ||
| testicular granulosa cell tumor | DOID:5331 | J:149060 | ||
