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Transgene Detail
Symbol: Tg(Upk2-HRAS*Q61L)5Xrw
Name: transgene insertion 5, Xue-ru Wu
MGI ID: MGI:3522719
Synonyms: UPII/Ha-ras 5, UPII-Ras*
Transgene: Tg(Upk2-HRAS*Q61L)5Xrw  Location: unknown  
Alliance: Tg(Upk2-HRAS*Q61L)5Xrw page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Upk2-HRAS*Q61L)5Xrw expresses 1 gene
Mutation detailsThis transgene included a 3.6 kb fragment encoding the muring Upk2 gene promoter placed upstream of a 3.0 kb sequence encoding a mutant rabbit Hras gene (glutamine to leucine point mutation at codon 61). Mice carrying this allele produced only a single fragment, 8.2 kb in length, corresponding to a tail to tail orientation. Approximately 2 copies of the transgene were inserted into the genome. (J:69251)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Tg(Upk2-HRAS*Q61L)5Xrw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:69251 Zhang ZT, et al., Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene. 2001 Apr 12;20(16):1973-80
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory