Tg(Upk2-HRAS*Q61L)5Xrw
Transgene Detail

Summary

• Symbol: Tg(Upk2-HRAS*Q61L)5Xrw
• Name: transgene insertion 5, Xue-ru Wu
• MGI ID: MGI:3522719
• Synonyms: UPII/Ha-ras 5, UPII-Ras*
• Transgene: Tg(Upk2-HRAS*Q61L)5Xrw Location: unknown
• Alliance: Tg(Upk2-HRAS*Q61L)5Xrw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Upk2-HRAS*Q61L)5Xrw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  rabbit, European	Hras (127486605)	Transgene codes for a protein with a glutamine to leucine mutation.

• Mutation details: This transgene included a 3.6 kb fragment encoding the muring Upk2 gene promoter placed upstream of a 3.0 kb sequence encoding a mutant rabbit Hras gene (glutamine to leucine point mutation at codon 61). Mice carrying this allele produced only a single fragment, 8.2 kb in length, corresponding to a tail to tail orientation. Approximately 2 copies of the transgene were inserted into the genome. (J:69251)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Upk2-HRAS*Q61L)5Xrw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69251 Zhang ZT, et al., Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene. 2001 Apr 12;20(16):1973-80
• All: 9 reference(s)