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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctnnb1
catenin beta 1
MGI:88276
356 phenotypes from 17 alleles in 65 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Amhr2tm3(cre)Bhr/\Amhr2+
\Ctnnb1tm1Mmt/\Ctnnb1+
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
male infertility J:186144
seminiferous tubule degeneration J:186144
testicular atrophy J:186144
\Amhr2tm3(cre)Bhr/\Amhr2+
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal Mullerian duct morphology J:171430
abnormal sex determination J:171430
failure of Mullerian duct regression J:171430
\Axin2tm1.1(cre/ERT2/tdTomato)Eem/\Axin2+
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
involves: 129S2/SvPas * C57BL/6 		decreased cell proliferation J:204142
\Bmi1tm1(cre/ERT)Mrc/\Bmi1+
\Ctnnb1tm1Mmt/\Ctnnb1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal crypts of Lieberkuhn morphology J:138364
increased intestinal adenoma incidence J:138364
premature death J:138364
\Ctnnb1Bfc/\Ctnnb1+
either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal eye morphology J:170646
abnormal head morphology J:170646
anophthalmia J:170646
cataract J:170646
flattened snout J:170646
forebrain hypoplasia J:170646
microphthalmia J:170646
preweaning lethality, incomplete penetrance J:170646
\Ctnnb1Bfc/\Ctnnb1+
involves: BALB/cCrl * C3H/HeNCrl 		abnormal globus pallidus morphology J:209611
abnormal hippocampus neuron morphology J:209611
abnormal operant conditioning behavior J:209611
abnormal spatial reference memory J:209611
abnormal synaptic vesicle clustering J:209611
abnormal vocalization J:209611
broad head J:63816, J:209611
decreased corpus callosum size J:209611
decreased prepulse inhibition J:209611
enlarged thalamus J:209611
impaired contextual conditioning behavior J:209611
impaired coordination J:209611
increased brain size J:209611
increased striatum size J:209611
ocular hypertelorism J:63816
reduced long-term potentiation J:209611
small cerebellum J:209611
small olfactory bulb J:209611
\Ctnnb1Bfc/\Ctnnb1Bfc
either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal head size J:170646
preweaning lethality, complete penetrance J:170646
\Ctnnb1em1V/\Ctnnb1em1V
\Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: C57BL/6 * C57BL/6J * CBA 		abnormal retina development J:328283
decreased angiogenesis J:328283
\Ctnnb1tm1.1Smoc/\Ctnnb1tm1.1Smoc
\Sox9em1(cre/ERT2)Tchn/\Sox9+
involves: C57BL/6 		increased incidence of tumors by chemical induction J:322311
\Ctnnb1tm1Kba/\Ctnnb1tm1Kba
involves: 129S6/SvEvTac * C57BL/6 		abnormal craniofacial development J:178971
abnormal forebrain development J:178971
decreased embryo size J:178971
embryonic growth retardation J:178971
small pharyngeal arch J:178971
\Ctnnb1tm1Max/\Ctnnb1tm1Max
involves: 129 * 129S1/Sv * 129X1/SvJ 		abnormal embryonic epiblast morphology J:29881
abnormal extraembryonic tissue morphology J:29881
abnormal germ layer development J:29881
absent allantois J:29881
absent amniotic folds J:29881
decreased embryo size J:29881
embryonic lethality during organogenesis, complete penetrance J:29881
\Ctnnb1tm1Max/\Ctnnb1tm2Kem
\Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal apical ectodermal ridge morphology J:81795
abnormal forelimb morphology J:81795
abnormal humerus morphology J:81795
abnormal suckling behavior J:81795
abnormal ulna morphology J:81795
absent deltoid tuberosity J:81795
absent hindlimb J:81795
increased ectoderm apoptosis J:81795
neonatal lethality, complete penetrance J:81795
\Ctnnb1tm1Max/\Ctnnb1tm2Kem
\Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal bone mineralization J:114494
abnormal bone ossification J:114494
abnormal cartilage morphology J:114494
abnormal limb development J:114494
arrested osteoblast differentiation J:114494
\Ctnnb1tm1Mmt/\Ctnnb1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal small intestinal crypt cell proliferation J:169830
abnormal small intestine morphology J:169830
increased intestinal adenoma incidence J:169830
\Ctnnb1tm1Mmt/\Ctnnb1+
involves: 129X1/SvJ 		no abnormal phenotype detected J:58367
\Ctnnb1tm1Mmt/\Ctnnb1+
\Krt19tm1(cre)Mmt/\Krt19+
involves: 129X1/SvJ 		increased intestinal adenoma incidence J:58367
premature death J:58367
\Ctnnb1tm1Mmt/\Ctnnb1+
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
\Ctnnb1tm1Mmt/\Ctnnb1+
\Krt14tm1.1(cre)Wbm/\Krt14+
involves: 129P2/OlaHsd * 129X1/SvJ 		normal neoplasm J:199091
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Pou3f4-cre)32Cren/?
involves: 129X1/SvJ 		abnormal brain morphology J:83935
abnormal nervous system morphology J:83935
increased brain size J:83935
increased spinal cord size J:83935
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Col2a1-cre)1Bhr/0
involves: 129X1/SvJ 		decreased length of long bones J:90567
lethality throughout fetal growth and development, incomplete penetrance J:90567
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal trabecular bone morphology J:112659
increased hepatoblastoma incidence J:112659
premature death J:112659
skin fibrosis J:112659
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Wap-cre)11738Mam/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam 		increased mammary gland tumor incidence in breeding females J:206839
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Pbsn-cre)4Prb/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		increased prostate gland adenocarcinoma incidence J:143034, J:284956
increased prostate intraepithelial neoplasia incidence J:143034, J:284956
premature death J:143034
squamous metaplasia of bulbourethral gland J:143034
squamous metaplasia of preputial gland J:143034
squamous metaplasia of urethral gland J:143034
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Tek-cre)1Ywa/0
involves: 129X1/SvJ * C57BL/6 * SJL 		embryonic lethality, complete penetrance J:178340
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Cdh16-cre)91Igr/0
involves: 129X1/SvJ * ICR 		dilated renal tubule J:151498
kidney cyst J:151498
postnatal lethality, complete penetrance J:151498
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Fabp1-cre)1Mmt/?
involves: 129X1/SvJ 		increased intestinal adenoma incidence J:58367
premature death J:58367
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Hoxb7-cre)13Amc/0
involves: 129X1/SvJ * C57BL/6 		abnormal kidney development J:160547
absent kidney J:160547
single kidney J:160547
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Col1a1-cre)1Kry/0
involves: 129X1/SvJ * FVB 		absent lower incisors J:98430
decreased osteoclast cell number J:98430
increased bone mass J:98430
increased osteoma incidence J:98430
lethality at weaning, complete penetrance J:98430
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Upk2-cre)6Xrw/0
involves: 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:164579, J:174242
normal neoplasm J:164579, J:174242
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129X1/SvJ * CD-1 		abnormal bone ossification J:114494
abnormal long bone epiphyseal plate morphology J:114494
abnormal osteoblast differentiation J:114494
abnormal osteoclast differentiation J:114494
abnormal trabecular bone morphology J:114494
delayed intramembranous bone ossification J:114494
perinatal lethality, complete penetrance J:114494
premature endochondral bone ossification J:114494
short limbs J:114494
\Ctnnb1tm1Mmt/\Ctnnb1+
\Ctsktm1(cre)Ska/\Ctsk+
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
\Ctnnb1tm1Mmt/\Ctnnb1+
\Lgr5tm1(cre/ERT2)Cle/\Lgr5+
involves: 129P2/OlaHsd * 129X1/SvJ 		intestine polyps J:193873
\Ctnnb1tm1Mmt/\Ctnnb1+
\Nanos3tm2(cre)Ysa/\Nanos3+
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
decreased spermatogonia number J:257319
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(CYP19A1-cre)1Jri/0
involves: 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased ovary tumor incidence J:186144
premature death J:186144
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Tcfap2a-cre)1Will/0
involves: 129X1/SvJ * C57BL/6 		abnormal cartilage development J:168016
abnormal eye morphology J:168016
abnormal face development J:168016
abnormal facial morphology J:168016
abnormal mandibular prominence morphology J:168016
abnormal maxillary prominence morphology J:168016
abnormal Meckel's cartilage morphology J:168016
abnormal medial nasal prominence morphology J:168016
abnormal oral cavity morphology J:168016
absent outer ear J:168016
absent vibrissae J:168016
ectopic cartilage J:168016
embryonic lethality during organogenesis, incomplete penetrance J:168016
lethality throughout fetal growth and development, incomplete penetrance J:168016
\Ctnnb1tm1Mmt/\Ctnnb1+
\Dclk1tm1.1(cre/ERT2)Seno/\Dclk1+
involves: 129X1/SvJ * C57BL/6 		normal neoplasm J:193873
\Ctnnb1tm1Mmt/\Ctnnb1+
\Sox2tm1.1(cre/ERT2)Jpmb/\Sox2+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal adenohypophysis morphology J:201265
increased pituitary gland tumor incidence J:201265
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Msx2-rtTA)885Lma/0
\Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 		abnormal craniofacial morphology J:202618
abnormal urinary bladder morphology J:202618
alopecia J:202618
increased urinary bladder carcinoma incidence J:202618
premature death J:202618
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
involves: 129X1/SvJ 		no abnormal phenotype detected J:58367
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Gli1tm3(cre/ERT2)Alj/\Gli1+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal external female genitalia morphology J:148515
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal muscle development J:124278
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Nanos3tm2(cre)Ysa/\Nanos3+
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
decreased spermatogonia number J:257319
decreased testis weight J:257319
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Osr2tm5(cre)Jian/\Osr2+
involves: 129X1/SvJ 		abnormal dental mesenchyme morphology J:153554
abnormal tooth development J:153554
cleft palate J:153554
neonatal lethality J:153554
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Shhtm1(EGFP/cre)Cjt/\Shh+
involves: 129X1/SvJ 		abnormal lung development J:204743
abnormal lung vasculature morphology J:204743
abnormal pulmonary artery morphology J:204743
abnormal pulmonary vein morphology J:204743
absent lungs J:204743
normal cardiovascular system phenotype J:204743
tracheoesophageal fistula J:153098
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tcf21tm1(cre)Seq/\Tcf21+
involves: 129S1/Sv * 129X1/SvJ 		abnormal kidney development J:189643
hydroureter J:189643
kidney cyst J:189643
neonatal lethality J:189643
renal hypoplasia J:189643
ureter hypoplasia J:189643
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tg(Cryaa-cre)10Mlr/0
involves: 129X1/SvJ * FVB/N 		abnormal lens epithelium morphology J:152850
increased lens epithelium apoptosis J:152850
microphthalmia J:152850
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		ectopic limbs J:223057
polydactyly J:223057
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal trabecular bone morphology J:112659
increased hepatoblastoma incidence J:112659
premature death J:112659
skin fibrosis J:112659
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tg(Pitx1-cre)7Rsd/0
involves: 129X1/SvJ * BALB/c * C57BL/6 		absent pituitary gland J:114817
\Ctnnb1tm1Mmt/\Ctnnb1tm1Mmt
\Tg(Upk2-cre)6Xrw/0
involves: 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:164579, J:234236
normal neoplasm J:164579
\Ctnnb1tm1Wbm/\Ctnnb1tm1Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
\Ctnnb1tm1Yy/\Ctnnb1tm1.1Yy
\Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal perichondrium morphology J:112462
decreased bone mineralization J:112462
failure of bone ossification J:112462
increased chondrocyte apoptosis J:112462
\Ctnnb1tm1Yy/\Ctnnb1tm1Yy
\Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 		domed cranium J:93028
fused synovial joints J:93028
neonatal lethality, complete penetrance J:93028
short limbs J:93028
\Ctnnb1tm1Yy/\Ctnnb1tm1Yy
\Tg(Prnp-GFP/cre)1Blw/0
involves: 129S6/SvEvTac * C57BL/6 		domed cranium J:93028
fused synovial joints J:93028
neonatal lethality, complete penetrance J:93028
short limbs J:93028
\Ctnnb1tm1Yy/\Ctnnb1tm1Yy
\Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		abnormal hair follicle development J:184918
abnormal ligament morphology J:184918
abnormal limb development J:184918
abnormal melanogenesis J:184918
abnormal tendon morphology J:184918
\Ctnnb1tm1Yy/\Ctnnb1tm1Yy
\Twist2tm1(cre)Dor/\Twist2+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		fused synovial joints J:93028
\Ctnnb1tm2.1Kem/\Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal inner cell mass morphology J:67966
absent mesoderm J:178971
embryonic lethality between implantation and somite formation, complete penetrance J:178971
embryonic lethality, complete penetrance J:67966
\Ctnnb1tm2Kem/\Ctnnb1+
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
\Ctnnb1tm2Kem/\Ctnnb1+
\Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
\Ctnnb1tm2Kem/\Ctnnb1+
\Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL 		abnormal skeleton morphology J:173242
\Ctnnb1tm2Kem/\Ctnnb1+
\Ctsktm1(cre)Ska/\Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
\Ctnnb1tm2Kem/\Ctnnb1+
\Osr2tm2(cre)Jian/\Osr2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal enamel knot morphology J:153554
cleft secondary palate J:153554
growth retardation of incisors J:153554
growth retardation of molars J:153554
neonatal lethality J:153554
\Ctnnb1tm2Kem/\Ctnnb1+
\Nanos3tm2(cre)Ysa/\Nanos3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
decreased spermatogonia number J:257319
decreased testis weight J:257319
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Edil3Tg(Sox2-cre)1Amc/\Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA 		abnormal embryonic tissue morphology J:187739
prenatal lethality, complete penetrance J:187739
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129/Sv * C57BL/6 * CBA 		abnormal brain development J:67966
abnormal brain morphology J:67966
abnormal cranial nerve morphology J:67966
abnormal dorsal root ganglion morphology J:67966
abnormal facial nerve morphology J:67966
abnormal glossopharyngeal nerve morphology J:67966
abnormal hindbrain morphology J:67966
abnormal hypoglossal nerve morphology J:67966
abnormal neural tube morphology J:67966
abnormal telencephalon morphology J:67966
abnormal trigeminal V mesencephalic nucleus morphology J:67966
abnormal vagus nerve morphology J:67966
absent cerebellum J:67966
absent choroid plexus J:67966
absent craniofacial bones J:67966
absent metencephalon J:67966
absent midbrain J:67966
absent midbrain-hindbrain boundary J:67966
absent oculomotor nerve J:67966
prenatal lethality, complete penetrance J:67966
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Kdrtm1(cre)Sato/\Kdr+
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood-brain barrier function J:142352
abnormal vasculogenesis J:142352
embryonic lethality during organogenesis, complete penetrance J:142352
intracranial hemorrhage J:142352
spinal hemorrhage J:142352
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129X1/SvJ 		neonatal lethality, complete penetrance J:187739
skin lesions J:187739
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal somite development J:200549
caudal body truncation J:200549
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Tg(T-cre/ERT2)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr 		abnormal axial mesoderm morphology J:200549
abnormal somite development J:200549
caudal body truncation J:200549
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal blood vessel morphology J:85505
abnormal endocardium morphology J:85505
abnormal placenta morphology J:85505
abnormal placental labyrinth vasculature morphology J:85505
abnormal umbilical cord blood vessel morphology J:85505
abnormal vascular endothelial cell morphology J:85505
abnormal visceral yolk sac morphology J:85505
abnormal vitelline vasculature morphology J:85505
embryonic lethality during organogenesis, complete penetrance J:85505
hemorrhage J:85505
pale yolk sac J:85505
pericardial edema J:85505
small heart J:85505
thin placenta labyrinth J:85505
\Ctnnb1tm2Kem/\Ctnnb1tm2.1Kem
\Tg(Zp3-cre)93Knw/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		abnormal embryonic tissue morphology J:187739
prenatal lethality, complete penetrance J:187739
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		decreased response of heart to induced stress J:109612
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Ctsktm1(cre)Ska/\Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Emx1tm1(cre)Yql/\Emx1+
B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem 		abnormal cerebral cortex morphology J:92923
abnormal hippocampus morphology J:92923
abnormal nursing J:92923
absent corpus callosum J:92923
absent dentate gyrus J:92923
absent hippocampal commissure J:92923
absent hippocampus CA1 region J:92923
absent hippocampus CA2 region J:92923
absent hippocampus CA3 region J:92923
decreased body size J:92923
dilated lateral ventricle J:92923
increased susceptibility to pharmacologically induced seizures J:92923
male infertility J:92923
seizures J:92923
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129 * C57BL/6 * CBA/J 		abnormal craniofacial morphology J:178971
abnormal neural tube morphology J:178971
abnormal telencephalon development J:178971
absent midbrain-hindbrain boundary J:178971
premature neuronal precursor differentiation J:178971
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Nanos3tm2(cre)Ysa/\Nanos3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
decreased spermatogonia number J:257319
decreased testis weight J:257319
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Olig2tm1(cre)Tmj/\Olig2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord medial motor column morphology J:178688
decreased motor neuron number J:178688
neonatal lethality, complete penetrance J:178688
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Osr2tm2(cre)Jian/\Osr2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal joint morphology J:171478
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Pvalbtm1(cre)Arbr/\Pvalb+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal head movements J:236989
abnormal nest building behavior J:236989
abnormal neuron physiology J:236989
abnormal response to social novelty J:236989
normal behavior/neurological phenotype J:236989
enhanced spatial learning J:236989
impaired long-term object recognition memory J:236989
increased anxiety-related response J:236989
increased grooming behavior J:236989
increased thigmotaxis J:236989
slow extinction of fear memory J:236989
stereotypic behavior J:236989
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Shhtm1(EGFP/cre)Cjt/\Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung development J:153098
absent lung buds J:153098
absent lungs J:153098
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tcf21tm1(cre)Seq/\Tcf21+
involves: 129S1/Sv * 129X1/SvJ 		abnormal kidney development J:189643
fused kidneys J:189643
increased tumor incidence J:189643
prenatal lethality J:189643
renal hypoplasia J:189643
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		decreased bone mass J:98430
increased osteoclast cell number J:98430
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Col2a1-cre)1Bhr/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal cartilage morphology J:90567
abnormal chondrocyte morphology J:90567
abnormal craniofacial bone morphology J:90567
decreased length of long bones J:90567
domed cranium J:90567
short limbs J:90567
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal long bone morphology J:114494
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Cyp1a1-cre)1Dwi/0
involves: C57BL/6 * CBA 		abnormal crypts of Lieberkuhn morphology J:92092
abnormal intestinal epithelium morphology J:92092
decreased Paneth cell number J:92092
ectopic Paneth cells J:92092
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Dct-lacZ)A12Jkn/0
\Tg(Tyr-cre)1Lru/0
B6.Cg-Ctnnb1tm2Kem Tg(Tyr-cre)1Lru Tg(Dct-lacZ)A12Jkn 		abnormal melanoblast morphology J:176245
decreased melanoblast proliferation J:176245
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Hoxb7-cre)5526Cmb/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal kidney morphology J:136068
absent kidney J:136068
absent nephrogenic zone J:136068
decreased kidney cell proliferation J:136068
decreased kidney collecting duct number J:136068
decreased nephron number J:136068
hydroureter J:136068
impaired branching involved in ureteric bud morphogenesis J:136068
increased metanephric mesenchyme apoptosis J:136068
neonatal lethality, complete penetrance J:136068
small kidney J:136068
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal hair cycle anagen phase J:204142
abnormal hair follicle morphology J:204142
abnormal hair growth J:204142
normal integument phenotype J:204142
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(KRT5-rtTA)#Glk/0
\Tg(tetO-cre)1Jaw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal dermis papillary layer morphology J:204142
abnormal epidermal layer morphology J:204142
abnormal hair cycle anagen phase J:204142
abnormal hair follicle infundibulum morphology J:204142
abnormal hair follicle morphology J:204142
abnormal hair growth J:204142
abnormal keratinocyte morphology J:204142
accelerated hair follicle regression J:204142
decreased hair follicle number J:204142
hair follicle degeneration J:204142
increased hair follicle apoptosis J:204142
thick epidermis J:204142
thick epidermis stratum basale J:204142
thick epidermis suprabasal layer J:204142
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(KRT14-cre)#Smr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J 		abnormal filiform papillae morphology J:242196
abnormal tongue morphology J:242196
decreased cell proliferation J:242196
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(KRT14-cre/ERT)20Efu/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal epidermal layer morphology J:204142
cutaneous mastocytosis J:204142
normal integument phenotype J:204142
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal autopod morphology J:223057
absent deltoid tuberosity J:223057
absent hindlimb J:223057
absent radius J:223057
decreased diameter of humerus J:223057
short ulna J:223057
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA 		abnormal retina vasculature morphology J:144980
abnormal vascular regression J:144980
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Pitx1-cre)7Rsd/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal adenohypophysis morphology J:114817
absent lactotrophs J:114817
absent somatotrophs J:114817
absent thyrotrophs J:114817
decreased gonadotroph cell number J:114817
increased corticotroph cell number J:114817
small adenohypophysis J:114817
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Tcfap2a-cre)1Will/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal face development J:168016
abnormal facial morphology J:168016
abnormal lateral nasal prominence morphology J:168016
abnormal lens development J:168016
abnormal mandibular prominence morphology J:168016
abnormal maxillary shelf morphology J:168016
abnormal maxillary zygomatic process morphology J:168016
abnormal medial nasal prominence morphology J:168016
abnormal nasal placode morphology J:168016
abnormal neurocranium morphology J:168016
abnormal optic eminence morphology J:168016
abnormal tympanic ring morphology J:168016
absent eyelids J:168016
absent hyoid bone J:168016
absent mandible J:168016
decreased middle ear ossicle number J:168016
fusion of basioccipital and basisphenoid bone J:168016
narrow frontonasal prominence J:168016
neonatal lethality, complete penetrance J:168016
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased bone resorption J:178340
decreased osteoclast cell number J:178340
increased bone volume J:178340
osteopetrosis J:178340
prenatal lethality, incomplete penetrance J:178340
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Tg(Tyr-cre)1Lru/0
B6.Cg-Ctnnb1tm2Kem Tg(Tyr-cre)1Lru 		abnormal hair follicle melanogenesis J:176245
abnormal pinna hair pigmentation J:176245
abnormal tail hair pigmentation J:176245
absent coat pigmentation J:176245
reduced hair shaft melanin granule number J:176245
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Twist2tm1(cre)Dor/\Twist2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal joint morphology J:178499
abnormal skeleton morphology J:178499
arrested osteoblast differentiation J:178499
ectopic cartilage J:178499
failure of bone ossification J:178499
split sternum J:178499
\Ctnnb1tm2Kem/\Ctnnb1tm3Kba
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129 * C57BL/6 * CBA/J 		abnormal craniofacial morphology J:178971
abnormal midbrain morphology J:178971
abnormal neuron differentiation J:178971
normal embryo phenotype J:178971
\Ctnnb1tm2Wbm/\Ctnnb1tm2Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
\Ctnnb1tm3Kba/\Ctnnb1tm3Kba
involves: 129S6/SvEvTac * C57BL/6 		abnormal gastrulation J:178971
absent mesoderm J:178971
embryonic lethality between implantation and somite formation, complete penetrance J:178971
\Ctnnb1tm3Wbm/\Ctnnb1tm3Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
\Ctnnb1tm4Wbm/\Ctnnb1+
\Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd 		absent hair follicles J:186934
alopecia J:186934
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Gli1tm3(cre/ERT2)Alj/\Gli1+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal external male genitalia morphology J:148515
abnormal foreskin morphology J:148515
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Krt14tm1(cre)Wbm/\Krt14+
involves: 129P2/OlaHsd 		decreased gamma-delta T cell number J:202499
increased neutrophil cell number J:202499
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Krt14tm1(cre)Wbm/\Krt14+
involves: 129P2/OlaHsd * C57BL/6 		abnormal hair growth J:69463
alopecia J:69463
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Krt14tm1.1(cre)Wbm/\Krt14+
involves: 129P2/OlaHsd * C57BL/6 		abnormal hair growth J:69463
alopecia J:69463
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Pax3tm1(cre)Joe/\Pax3+
Not Specified 		abnormal neural tube morphology J:96431
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(Cryaa-cre)10Mlr/?
involves: 129P2/OlaHsd * FVB/N 		abnormal lens capsule morphology J:139969
abnormal lens epithelium morphology J:139969
disorganized secondary lens fibers J:139969
focal hair loss J:139969
loss of vibrissae J:139969
microphthalmia J:139969
ruptured lens capsule J:139969
small lens J:139969
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(Cryaa-cre,Tyr)39Mlr/?
involves: 129P2/OlaHsd * FVB/N 		nuclear cataract J:139969
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd 		absent hair follicles J:155012
neonatal lethality, complete penetrance J:155012
thick epidermis J:155012
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * FVB/N 		abnormal exocrine pancreas morphology J:119908
abnormal pancreas morphology J:119908
abnormal pancreas physiology J:119908
decreased body size J:119908
decreased pancreas weight J:119908
pancreas fibrosis J:119908
pancreas inflammation J:119908
pancreatic acinar hypoplasia J:119908
premature death J:119908
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(Pou3f4-cre)32Cren/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain morphology J:83935
abnormal nervous system morphology J:83935
decreased brain size J:83935
decreased spinal cord size J:83935
\Ctnnb1tm4Wbm/\Ctnnb1tm4Wbm
\Tg(Prrx1-cre)98Mlgn/0
involves: 129P2/OlaHsd 		abnormal forelimb morphology J:157917
abnormal hindlimb morphology J:157917
abnormal limb development J:157917
\Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh/\Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6 		abnormal cell physiology J:187862
\Tg(Dct-lacZ)A12Jkn/0
\Tg(Tyr-Ctnnb1/EGFP)#Lru/0
B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru Tg(Dct-lacZ)A12Jkn 		abnormal melanoblast morphology J:176245
decreased melanoblast proliferation J:176245
\Tg(Tyr-Ctnnb1/EGFP)#Lru/0
B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru 		abnormal hair follicle melanogenesis J:176245
abnormal pinna hair pigmentation J:176245
abnormal tail hair pigmentation J:176245
diluted coat color J:176245
reduced hair shaft melanin granule number J:176245
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory