Cdkn1a^tm1Led
Targeted Allele Detail

Summary

• Symbol: Cdkn1a^tm1Led
• Name: cyclin dependent kinase inhibitor 1A; targeted mutation 1, Philip Leder
• MGI ID: MGI:1888950
• Synonyms: p21-, p21^Cip1, p21^Cip1/Waf1 -, p21^CIP1/WAF1
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28420
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin resistance cassette replaced a 3kb sequence containing exon 2. (J:28420)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	33 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1a^tm1Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 60 strains or lines available

References

• Original: J:28420 Deng C, et al., Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25;82(4):675-84
• All: 139 reference(s)