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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctnnb1
catenin beta 1
MGI:88276
254 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ 		anemia J:142150
decreased hematocrit J:142150
extramedullary hematopoiesis J:142150
increased granulosa cell tumor incidence J:149060
increased metastatic potential J:142150, J:149060
increased ovary tumor incidence J:142150
increased testis tumor incidence J:149060
premature death J:142150
pulmonary embolism J:142150
seminiferous tubule degeneration J:149060
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
ApcMin/ApcMin
Ctnnb1tm4.1Wbm/Ctnnb1+
involves: 129 * 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:156864
ApcMin/Apctm1Tno
Ctnnb1tm4.1Wbm/Ctnnb1+
involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal craniofacial phenotype J:156864
increased hepatocellular carcinoma incidence J:156864
intestine polyps J:156864
normal nervous system phenotype J:156864
Apctm1Rak/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal telencephalon development J:185942
embryonic lethality, complete penetrance J:185942
rostral body truncation J:185942
Apctm1Rsmi/Apc+
Ctnnb1tm1Wvv/Ctnnb1+
Tg(Fabp1-cre)1Jig/?
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		increased gastrointestinal tumor incidence J:185942
Apctm1Tno/Apctm1Tno
Ctnnb1tm4.1Wbm/Ctnnb1+
involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased tumor incidence J:156864
Apctm2Rfo/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality, complete penetrance J:185942
rostral body truncation J:185942
Axin1tm4Cos/Axin1tm4Cos
Ctnnb1tm2.1Kem/Ctnnb1+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal brain morphology J:147293
abnormal facial morphology J:147293
abnormal head morphology J:147293
abnormal nose morphology J:147293
cleft palate J:147293
normal mortality/aging J:147293
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Ctnnb1tm1Mmt/Ctnnb1+
Krt14tm1.1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ 		decreased tumor-free survival time J:199091
increased hair follicle number J:199091
increased salivary gland tumor incidence J:199091
increased squamous cell carcinoma incidence J:199091
Cdkn1atm1Led/Cdkn1atm1Led
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N 		increased urinary bladder carcinoma incidence J:234236
premature death J:234236
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Rps/Ptentm1Rps
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129/Sv * C57BL/6J * FVB * SJL 		increased melanoma incidence J:155731
Col1a1tm2(tetO-CTNNB1*)Hoch/Col1a1tm2(tetO-CTNNB1*)Hoch
Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
involves: 129S4/SvJae * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:191050
abnormal intestinal epithelium morphology J:191050
abnormal intestinal goblet cell morphology J:191050
abnormal large intestine crypts of Lieberkuhn morphology J:191050
abnormal small intestine crypts of Lieberkuhn morphology J:191050
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal eye morphology J:170646
abnormal head morphology J:170646
preweaning lethality, incomplete penetrance J:170646
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6) 		abnormal head size J:170646
caudal body truncation J:170646
Ctnnb1Bfc/Ctnnb1+
Lrp6Gw/Lrp6+
either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6) 		abnormal head size J:170646
Ctnnb1Bfc/Ctnnb1Bfc
Dkk1tm1Lmgd/Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal head size J:170646
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cervical lymph node morphology J:71744
abnormal coat appearance J:71744
abnormal coat/ hair morphology J:71744
abnormal cornea epithelium morphology J:71744
abnormal cornea stroma morphology J:71744
abnormal eye morphology J:71744
abnormal eyelid margin morphology J:71744
abnormal foot pad morphology J:71744
abnormal hair follicle development J:71744
abnormal hair growth J:71744
abnormal intestinal goblet cell morphology J:71744
abnormal macrophage physiology J:71744
abnormal nitric oxide homeostasis J:71744
abnormal peripheral lymph node morphology J:71744
abnormal small intestine morphology J:71744
abnormal sweat gland morphology J:71744
abnormal vibrissa follicle morphology J:71744
absent hair follicles J:71744
absent Meibomian glands J:71744
absent peripheral lymph nodes J:71744
absent Peyer's patches J:71744
absent popliteal lymph nodes J:71744
alopecia J:71744
blindness J:71744
conjunctivitis J:71744
deafness J:71744
decreased body size J:71744
decreased hair follicle number J:71744
decreased litter size J:71744
decreased Peyer's patch number J:71744
domed cranium J:71744
dry eyes J:71744
early eyelid opening J:71744
gastrointestinal hemorrhage J:71744
growth retardation of incisors J:71744
growth retardation of molars J:71744
Harderian gland atrophy J:71744
hunched posture J:71744
impaired balance J:71744
increased granulocyte number J:71744
increased hair follicle apoptosis J:71744
increased hepatocyte apoptosis J:71744
increased inflammatory response J:71744
increased leukocyte cell number J:71744
increased susceptibility to otitis media J:71744
increased susceptibility to parasitic infection J:71744
keratoconjunctivitis sicca J:71744
kinked tail J:71744
lethargy J:71744
liver hemorrhage J:71744
misaligned incisors J:71744
narrow eye opening J:71744
premature death J:71744
prenatal lethality, incomplete penetrance J:71744
short incisors J:71744
small axillary lymph nodes J:71744
small brachial lymph nodes J:71744
small molars J:71744
small Peyer's patches J:71744
sparse vibrissae J:71744
tremors J:71744
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1tm1(Nfkbia)Rsu
involves: 129P2/OlaHsd * C57BL/6 		prenatal lethality, complete penetrance J:71744
Ctnnb1tm1.2Wvv/Ctnnb1+
involves: 129P2/OlaHsd * C57BL/6J 		increased gastrointestinal tumor incidence J:185942
increased intestinal adenocarcinoma incidence J:185942
increased intestinal adenoma incidence J:185942
Ctnnb1tm1.2Wvv/Ctnnb1tm1.2Wvv
involves: 129P2/OlaHsd * C57BL/6J 		abnormal anterior head development J:185942
abnormal craniofacial development J:185942
abnormal cranium morphology J:185942
abnormal head morphology J:185942
abnormal mandibular prominence morphology J:185942
abnormal maxillary prominence morphology J:185942
abnormal nasal capsule morphology J:185942
abnormal tongue morphology J:185942
absent maxilla J:185942
facial cleft J:185942
microcephaly J:185942
perinatal lethality, complete penetrance J:185942
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1Icar/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S * 129X1/SvJ * C57BL/6 		abnormal forebrain development J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S * 129X1/SvJ * C57BL/6 		abnormal forebrain development J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Ctnnb1tm1Max/Ctnnb1tm2Kem
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S * 129X1/SvJ * C57BL/6 		anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Ctnnb1tm1Mmt/Ctnnb1+
Tcf7tm1Cle/Tcf7+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal bone structure J:98430
Ctnnb1tm1Mmt/Ctnnb1+
Trp53tm1Brn/Trp53+
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		increased medulloblastoma incidence J:186709
Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:174242
increased lung tumor incidence J:174242
normal neoplasm J:174242
premature death J:174242
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		decreased circulating estradiol level J:186144
decreased circulating progesterone level J:186144
decreased granulosa cell apoptosis J:186144
decreased tumor-free survival time J:186144
impaired granulosa cell differentiation J:186144
increased circulating follicle stimulating hormone level J:186144
increased circulating luteinizing hormone level J:186144
increased granulosa cell proliferation J:186144
increased granulosa cell tumor incidence J:186144
increased ovary tumor incidence J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0
involves: 129S4/SvJae * 129X1/SvJ * FVB/N 		increased urinary bladder carcinoma incidence J:164579
premature death J:164579
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig 		abnormal mammary gland growth during lactation J:206839
abnormal mammary gland morphology J:206839
increased mammary gland tumor incidence in breeding females J:206839
increased mammary gland tumor incidence in virgin females J:206839
mammary gland alveolar hyperplasia J:206839
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
seminiferous tubule degeneration J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
involves: 129S4/SvJae * 129X1/SvJ * FVB/N 		increased lung tumor incidence J:174242
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		decreased circulating estradiol level J:186144
decreased circulating progesterone level J:186144
impaired granulosa cell differentiation J:186144
increased circulating follicle stimulating hormone level J:186144
increased circulating luteinizing hormone level J:186144
increased granulosa cell tumor incidence J:186144
increased ovary tumor incidence J:186144
premature death J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Prom1tm1(cre/ERT2)Gilb/Prom1+
involves: 129S6/SvEvTac * 129X1/SvJ 		increased intestinal adenocarcinoma incidence J:144215
premature death J:144215
Ctnnb1tm1Mmt/Ctnnb1+
Cxcr4tm2Yzo/Cxcr4tm2Yzo
Tg(Wap-cre)11738Mam/0
Tg(Wap-Hgf)402Mig/0
FVB.Cg-Cxcr4tm2Yzo Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig 		decreased mammary gland tumor incidence in breeding females J:206839
Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
involves: 129X1/SvJ * ICR 		kidney cyst J:151498
Ctnnb1tm1Mmt/Ctnnb1+
Krastm1Bbd/Kras+
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		increased prostate gland tumor incidence J:143034
premature death J:143034
squamous metaplasia of bulbourethral gland J:143034
squamous metaplasia of urethral gland J:143034
Ctnnb1tm1Mmt/Ctnnb1+
Rspo1tm1Mcch/Rspo1tm1Mcch
Tg(Nr5a1-cre)5Asc/?
involves: 129/Sv * C57BL/6 * CBA 		embryonic lethality, incomplete penetrance J:133933
normal reproductive system phenotype J:133933
Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal osteoclast differentiation J:178340
abnormal trabecular bone morphology J:178340
absent bone marrow cell J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
decreased osteoclast cell number J:178340
extramedullary hematopoiesis J:178340
increased bone trabecula number J:178340
increased bone volume J:178340
increased compact bone volume J:178340
increased splenocyte number J:178340
increased trabecular bone thickness J:178340
increased trabecular bone volume J:178340
osteopetrosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm1Mmt/Ctnnb1+
Pik3catm1Gilb/Pik3ca+
Trp53tm1Brn/Trp53+
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		increased medulloblastoma incidence J:186709
Ctnnb1tm1Mmt/Ctnnb1+
Igs2tm1(CAG-Met)Zsu/Igs2+
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N 		increased prostate gland adenocarcinoma incidence J:284956
increased prostate intraepithelial neoplasia incidence J:284956
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: 129X1/SvJ * C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
involves: 129S4/SvJae * 129X1/SvJ * FVB/N 		increased urinary bladder carcinoma incidence J:234236
premature death J:234236
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0
involves: 129S4/SvJae * 129X1/SvJ * FVB/N 		increased urinary bladder carcinoma incidence J:164579
premature death J:164579
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Sp8tm1Smb/Sp8tm1Smb
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Tg(Upk2-HRAS*Q61L)5Xrw/0
involves: 129X1/SvJ * FVB/N 		hematuria J:234236
increased urinary bladder carcinoma incidence J:234236
premature death J:234236
Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal elbow joint morphology J:112462
abnormal long bone hypertrophic chondrocyte zone J:112462
abnormal perichondrium morphology J:112462
arrested osteoblast differentiation J:112462
normal craniofacial phenotype J:112462
decreased bone mineralization J:112462
delayed endochondral bone ossification J:112462
fused synovial joints J:112462
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal eye morphology J:71744
abnormal eyelid morphology J:71744
abnormal hair follicle development J:71744
abnormal hair growth J:71744
abnormal incisor morphology J:71744
abnormal intestinal goblet cell morphology J:71744
abnormal lymph node morphology J:71744
abnormal macrophage physiology J:71744
abnormal molar morphology J:71744
abnormal Peyer's patch morphology J:71744
abnormal small intestine morphology J:71744
absent Meibomian glands J:71744
alopecia J:71744
blindness J:71744
deafness J:71744
decreased body size J:71744
decreased litter size J:71744
domed cranium J:71744
dry eyes J:71744
gastrointestinal hemorrhage J:71744
Harderian gland atrophy J:71744
hunched posture J:71744
increased granulocyte number J:71744
increased hepatocyte apoptosis J:71744
increased inflammatory response J:71744
increased leukocyte cell number J:71744
increased susceptibility to otitis media J:71744
keratoconjunctivitis sicca J:71744
kinked tail J:71744
lethargy J:71744
liver hemorrhage J:71744
prenatal lethality, incomplete penetrance J:71744
sparse hair J:71744
sparse vibrissae J:71744
tremors J:71744
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(Myh6-cre)2182Mds/0
B6.Cg-Ctnnb1tm2(Nfkbia)Rsu Tg(Myh6-cre)2182Mds 		decreased response of heart to induced stress J:111645
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1tm2(Nfkbia)Rsu
Tg(Runx2-icre)1Jtuc/0
involves: 129P2/OlaHsd * FVB/N 		normal skeleton phenotype J:160669
Ctnnb1tm2.1Kem/Ctnnb1+
Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
involves: 129/Sv * C57BL/6 * CBA 		abnormal rostral-caudal axis patterning J:103272
Ctnnb1tm2.1Kem/Ctnnb1+
Sall4Gt(W097E01)Flo/Sall4+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal anterior primitive streak morphology J:138922
abnormal mesoderm development J:138922
embryonic growth retardation J:138922
preweaning lethality, complete penetrance J:138922
Ctnnb1tm2Kba/Ctnnb1tm2Kba
involves: 129S6/SvEvTac * C57BL/6 		abnormal gastrulation J:178971
absent mesoderm J:178971
embryonic lethality between implantation and somite formation, complete penetrance J:178971
Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N 		abnormal blood vessel morphology J:135172
abnormal definitive hematopoiesis J:135172
premature death J:135172
Ctnnb1tm2Kem/Ctnnb1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0
Tg(tetO-Vegfa)90Ala/0
involves: 129 * C57BL/6 * FVB/N * ICR * SJL 		increased hemangioma incidence J:156474
normal skeleton phenotype J:156474
Ctnnb1tm2Kem/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S * 129X1/SvJ * C57BL/6 		abnormal forebrain development J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Ctnnb1tm2Kem/Ctnnb1+
Amer1tm1.1Nbar/Y
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL 		normal skeleton phenotype J:173242
Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal osteoclast physiology J:178340
abnormal trabecular bone morphology J:178340
decreased bone trabecula number J:178340
decreased trabecular bone mass J:178340
decreased trabecular bone thickness J:178340
decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Corintm2(cre)Bamo/Corin+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal auchene hair morphology J:160311
abnormal awl hair morphology J:160311
abnormal hair cycle anagen phase J:160311
abnormal hair cycle catagen phase J:160311
abnormal hair cycle telogen phase J:160311
abnormal hair follicle physiology J:160311
abnormal hair shaft morphology J:160311
abnormal zigzag hair morphology J:160311
decreased guard hair length J:160311
delayed hair regrowth J:160311
increased hair follicle apoptosis J:160311
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Zp3-cre)93Knw/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		abnormal embryonic tissue morphology J:187739
abnormal germ layer development J:187739
failure to gastrulate J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal brain morphology J:187739
abnormal craniofacial morphology J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		decreased body size J:187739
focal hair loss J:187739
normal integument phenotype J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Cdx1-cre)23Kem/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB 		caudal body truncation J:187739
prenatal lethality, complete penetrance J:187739
truncated tail bud J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J 		neonatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Cdx1-cre)23Kem/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB 		abnormal digit morphology J:187739
abnormal hindlimb morphology J:187739
abnormal neural tube morphology J:187739
abnormal rib morphology J:187739
abnormal sex gland morphology J:187739
abnormal vertebrae morphology J:187739
absent hindlimb J:187739
absent tail J:187739
brachydactyly J:187739
normal embryo phenotype J:187739
fused phalanges J:187739
open neural tube J:187739
perinatal lethality, complete penetrance J:187739
persistent cloaca J:187739
rib fusion J:187739
short ribs J:187739
small adrenal glands J:187739
small kidney J:187739
small vertebrae J:187739
vertebral fusion J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		decreased body size J:187739
normal integument phenotype J:187739
sparse hair J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA 		abnormal embryonic tissue morphology J:187739
abnormal germ layer development J:187739
failure to gastrulate J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal autopod morphology J:223057
abnormal hindlimb morphology J:223057
abnormal ulna morphology J:223057
normal limbs/digits/tail phenotype J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal reproductive system development J:223057
abnormal tail development J:223057
normal reproductive system phenotype J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * CBA/J 		absent hindbrain J:178971
absent mandible J:178971
absent maxilla J:178971
absent midbrain J:178971
absent midbrain-hindbrain boundary J:178971
small pharyngeal arch J:178971
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Juptm1Ruiz/Juptm1.1Tmj
Olig2tm1(cre)Tmj/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal dendrite morphology J:178688
lethality throughout fetal growth and development, complete penetrance J:178688
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Juptm1Ruiz/Juptm1Ruiz
Olig2tm1(cre)Tmj/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal neuronal migration J:178688
abnormal spinal cord lateral motor column morphology J:178688
abnormal spinal cord medial motor column morphology J:178688
abnormal spinal cord motor column morphology J:178688
abnormal ventral interneuron 1 morphology J:178688
abnormal ventral interneuron 2 morphology J:178688
decreased motor neuron number J:178688
embryonic lethality during organogenesis, complete penetrance J:178688
normal nervous system phenotype J:178688
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal osteoclast physiology J:178340
abnormal trabecular bone morphology J:178340
decreased bone resorption J:178340
decreased osteoclast cell number J:178340
extramedullary hematopoiesis J:178340
increased bone trabecula number J:178340
increased bone volume J:178340
increased compact bone volume J:178340
increased trabecular bone thickness J:178340
increased trabecular bone volume J:178340
osteopetrosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		abnormal osteoclast differentiation J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N 		embryonic lethality, complete penetrance J:135172
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Rac1tm1Djk/Rac1+
Tg(Msx2-cre)5Rem/0
involves: 129S4/SvJae 		abnormal forelimb morphology J:145305
absent hindlimb J:145305
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-EDN1,-lacZ)9Mhus/0
Tg(Tyr-cre/ERT2)13Bos/0
involves: C57BL/6J * FVB 		abnormal coat/hair pigmentation J:231435
abnormal epidermal melanocyte morphology J:231435
abnormal melanocyte differentiation J:231435
abnormal melanocyte proliferation J:231435
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * CBA/J 		abnormal cerebellum development J:178971
abnormal craniofacial bone morphology J:178971
absent midbrain-hindbrain boundary J:178971
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory