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Targeted Allele Detail
Symbol: Dkk1tm1Lmgd
Name: dickkopf WNT signaling pathway inhibitor 1; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI ID: MGI:2387760
Synonyms: Dkk1-
Gene: Dkk1  Location: Chr19:30523276-30526896 bp, - strand  Genetic Position: Chr19, 25.16 cM, cytoband C2
Alliance: Dkk1tm1Lmgd page
Germline Transmission:  Earliest citation of germline transmission: J:71787
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutants were identified by Southern blot analysis. (J:71787)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 315 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 20 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dkk1 Mutation:  18 strains or lines available
Original:  J:71787 Mukhopadhyay M, et al., Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell. 2001 Sep;1(3):423-34
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory