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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dkk1tm1Lmgd
targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI:2387760
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dkk1tm1Lmgd/Dkk1tm1Lmgd involves: 129S1/Sv * 129X1/SvJ MGI:3689397
hm2
Dkk1tm1Lmgd/Dkk1tm1Lmgd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3618757
hm3
Dkk1tm1Lmgd/Dkk1tm1Lmgd involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3697481
ht4
Dkk1tm1Lmgd/Dkk1+ involves: 129S1/Sv * 129X1/SvJ MGI:4947314
cx5
Dkk1tm1Lmgd/Dkk1+
Kremen1tm1Dgen/Kremen1tm1Dgen
Kremen2tm1Cni/Kremen2tm1Cni
either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1) MGI:3805007
cx6
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6) MGI:4947311
cx7
Ctnnb1Bfc/Ctnnb1Bfc
Dkk1tm1Lmgd/Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) MGI:4947313
cx8
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) MGI:4947312
cx9
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
involves: 101/H * 129 * BALB/c * C3H MGI:4947305
cx10
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6Gw
involves: 101/H * 129 * BALB/c * C3H MGI:4947306
cx11
Dkk1tm1Lmgd/Dkk1tm1Lmgd
Sfrp5tm1Shwl/Sfrp5tm1Shwl
involves: 129 * CD-1 MGI:3697480
cx12
Dkk1tm1Lmgd/Dkk1+
Gsctm2Bhr/Gsc+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716765
cx13
Dkk1tm1Lmgd/Dkk1+
Gsctm2Bhr/Gsctm2Bhr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716766


Genotype
MGI:3689397
hm1
Allelic
Composition
Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit complete truncations of the head unlike wild-type mice




Genotype
MGI:3618757
hm2
Allelic
Composition
Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all homozygotes die at birth

craniofacial
• at E17.5, the mutant interparietal bone is reduced relative to the wild-type
• at E17.5, the mutant parietal bone is reduced relative to the wild-type
• at E17.5, homozygotes lack a mandibular bone
• at E17.5, homozygotes lack a maxillary bone
• at E17.5, homozygotes lack a nasal bone
• at >E10.5, homozygotes lack all craniofacial structures anterior to the external ear
• absent at E9.5
• absent at E9.5
• a single tissue mass replaces the first pair of branchial arches in some mice

nervous system
• markedly reduced at E8.5 - E9.5 (J:119933)
• by E10.5, homozygotes exhibit truncation of portions of the midbrain
• at E11.5, homozygotes lack a diencephalon
• at E11.5, homozygotes lack a telencephalon

limbs/digits/tail
• at E10.5 and thereafter, homozygotes display defective limb outgrowth
• at E10.5-E11.5, the AER of mutant limb buds appears to be slightly thickened
• at >E11.5, mutant limb buds exhibit ectopic preaxial and postaxial digits
• at >E11.5, mutant limbs commonly display an extra digit I and/or an extra digit V
• at >E11.5, mutant limbs commonly display a fusion of digits II and III
• mutant forelimbs display fusion of digits and ectopic anterior and posterior digits, consistent with a severe reduction in programmed cell death and increased cell proliferation in developing limb bud cells
• homozygotes display truncation of the medial and distal elements of hindlimbs

skeleton
• at E17.5, the mutant interparietal bone is reduced relative to the wild-type
• at E17.5, the mutant parietal bone is reduced relative to the wild-type
• at E17.5, homozygotes lack a mandibular bone
• at E17.5, homozygotes lack a maxillary bone
• at E17.5, homozygotes lack a nasal bone

embryo
• a single tissue mass replaces the first pair of branchial arches in some mice
• by E10.5, homozygotes exhibit truncation of the forebrain and cephalic neural crest-derived head tissues
• at E11.5, all head derivatives anterior of the midbrain are absent
• starting at E8.5, homozygotes display a significant reduction in rostral tissue; however, the remaining anteroposterior body axis, as well as left-right asymmetry, appear unaffected
• at E10.5 and thereafter, homozygotes display defective limb outgrowth
• at E10.5-E11.5, the AER of mutant limb buds appears to be slightly thickened

vision/eye
• loss of eye evagination at E8.5 - E9.5
• eyes absent at E9.5

taste/olfaction
• absent at E9.5

respiratory system
• at E17.5, homozygotes lack a nasal bone
• absent at E9.5

growth/size/body
• at E17.5, homozygotes lack a nasal bone
• at E9.5 and thereafter, homozygotes lack major head structures anterior of the otic vesicle, including eyes, olfactory placodes, frontonasal mass, and mandibular processes
• by E17.5, homozygotes exhibit a severely truncated head
• at E8.5 - E9.5, head size is reduced by 35% compared to wild-type




Genotype
MGI:3697481
hm3
Allelic
Composition
Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at E17.5 7 of 10 mice lack anterior head structures
• Background Sensitivity: unlike mice on a mixed 129 and C57BL/6 background some mice on an outbred CD-1 background develop anterior head structures




Genotype
MGI:4947314
ht4
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 9% of mice exhibit reduced head compared with wild-type mice




Genotype
MGI:3805007
cx5
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Kremen1tm1Dgen/Kremen1tm1Dgen
Kremen2tm1Cni/Kremen2tm1Cni
Genetic
Background
either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Kremen1tm1Dgen mutation (0 available); any Kremen1 mutation (30 available)
Kremen2tm1Cni mutation (0 available); any Kremen2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• limb bone volume is increased compared to in wild-type mice but not compared to in Dkk1tm1Lmgd heterozygotes

limbs/digits/tail
• mice have ectopic postaxial forelimb digits
• the frequency and size of ectopic digits is increase compared to in Kremen1tm1Dgen Kremen2tm1Cni homozygotes
• 40% of ectopic digits originate at the carpus like regular digits unlike in Kremen1tm1Dgen Kremen2tm1Cni homozygotes where ectopic digits originate from digit V
• however, unlike in Dkk1 null mice webbing of bone elements is not observed




Genotype
MGI:4947311
cx6
Allelic
Composition
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
Genetic
Background
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1Bfc mutation (3 available); any Ctnnb1 mutation (48 available)
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Lrp6Gw mutation (0 available); any Lrp6 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• 23% of mice exhibit complete head truncation unlike wild-type mice

growth/size/body
• all mice exhibit head reduction defects unlike wild-type mice




Genotype
MGI:4947313
cx7
Allelic
Composition
Ctnnb1Bfc/Ctnnb1Bfc
Dkk1tm1Lmgd/Dkk1+
Genetic
Background
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1Bfc mutation (3 available); any Ctnnb1 mutation (48 available)
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• all mice exhibit head reduction defects unlike wild-type mice




Genotype
MGI:4947312
cx8
Allelic
Composition
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
Genetic
Background
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1Bfc mutation (3 available); any Ctnnb1 mutation (48 available)
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are produced
• viability is less than in Ctnnb1Bfc heterozygotes

vision/eye
• ocular defects are higher than in Ctnnb1Bfc heterozygotes

growth/size/body
• 92% of mice exhibit head defects compared with wild-type mice
• head defects are higher than in Ctnnb1Bfc heterozygotes




Genotype
MGI:4947305
cx9
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
Genetic
Background
involves: 101/H * 129 * BALB/c * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Lrp6Gw mutation (0 available); any Lrp6 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• in all mice

growth/size/body
• in 40-43% of mice




Genotype
MGI:4947306
cx10
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6Gw
Genetic
Background
involves: 101/H * 129 * BALB/c * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Lrp6Gw mutation (0 available); any Lrp6 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in 79% of mice




Genotype
MGI:3697480
cx11
Allelic
Composition
Dkk1tm1Lmgd/Dkk1tm1Lmgd
Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic
Background
involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Sfrp5tm1Shwl mutation (0 available); any Sfrp5 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable double homozygotes are found

embryo
N
• location of the anterior visceral endoderm and primitive streak morphology are similar to controls

growth/size/body
• at E17.5 9 of 18 mice lack anterior head structures
• this is not significantly different from Dkk1 single homozygotes on the same genetic background




Genotype
MGI:3716765
cx12
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Gsctm2Bhr/Gsc+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Gsctm2Bhr mutation (1 available); any Gsc mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size




Genotype
MGI:3716766
cx13
Allelic
Composition
Dkk1tm1Lmgd/Dkk1+
Gsctm2Bhr/Gsctm2Bhr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Gsctm2Bhr mutation (1 available); any Gsc mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• about 75% of embryos at E7.5 - E9.5 display abnormalities that vary in severity

nervous system
• at E8.5 and E9.5 variable truncations of the forebrain are seen ranging from mild reduction in head size (14.3% of embryos) to partial loss of the forebrain and ill-defined brain segments (42.8%) and in severely affected embryos (14.3%) anterior truncations resembling those in Dkk1 single homozygotes

vision/eye
• poor development of the eye primordium in moderately affected embryos (42.8%)

growth/size/body
• at E8.5 - E9.5, head size is reduced by 16% compared to wild-type





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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory