Kremen1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Kremen1^tm1Dgen
• Name: kringle containing transmembrane protein 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3804430
• Gene: Kremen1 Location: Chr11:5141552-5211558 bp, - strand Genetic Position: Chr11, 3.36 cM, cytoband A1
• Alliance: Kremen1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a LacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on lung and liver extracts. (J:137914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kremen1 Mutation: 30 strains or lines available

References

• Original: J:137914 Ellwanger K, et al., Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol. 2008 Aug;28(15):4875-82
• All: 2 reference(s)