Kremen2^tm1Cni
Targeted Allele Detail

Summary

• Symbol: Kremen2^tm1Cni
• Name: kringle containing transmembrane protein 2; targeted mutation 1, Christof Niehrs
• MGI ID: MGI:3804431
• Gene: Kremen2 Location: Chr17:23960171-23964807 bp, - strand Genetic Position: Chr17, 12.03 cM
• Alliance: Kremen2^tm1Cni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 5 were replaced with a lacZ and neo cassette. The absence of transcript expression was confirmed by whole mount in situ hybridization. (J:137914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kremen2 Mutation: 28 strains or lines available

References

• Original: J:137914 Ellwanger K, et al., Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol. 2008 Aug;28(15):4875-82
• All: 2 reference(s)