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Targeted Allele Detail
Symbol: Ctnnb1tm2(Nfkbia)Rsu
Name: catenin (cadherin associated protein), beta 1; targeted mutation 2, Ruth Schmidt-Ullrich
MGI ID: MGI:3039784
Synonyms: cloxPIkappaBalphadeltaN, dNflox, IkBaDeltaN(loxP-DeltaN)
Gene: Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance: Ctnnb1tm2(Nfkbia)Rsu page
Germline Transmission:  Earliest citation of germline transmission: J:71744
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
Ctnnb1tm2(Nfkbia)Rsu expresses 1 gene
Mutation detailsThis allele is similar to Catnnb1tm1(Nfkbia)Rsu in that an Nfkbia cDNA encoding amino acids 71 through 317 was inserted at the start codon of Catnnb1, but in this case, a floxed stop cassette preceded the Nfkbia sequence, precluding its expression. As in Catnnb1tm1(Nfkbia)Rsu, the coding region of the first coding exon and the following 4 downstream exons were deleted. (J:71744)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  39 strains or lines available
Original:  J:71744 Schmidt-Ullrich R, et al., Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory