Ctnnb1^{tm2(Nfkbia)Rsu}
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^{tm2(Nfkbia)Rsu}
• Name: catenin beta 1; targeted mutation 2, Ruth Schmidt-Ullrich
• MGI ID: MGI:3039784
• Synonyms: c^{loxPIkappaBalphadeltaN}, dN^flox, IkBaDeltaN(loxP-DeltaN)
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^{tm2(Nfkbia)Rsu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
• Mutations: Insertion, Intragenic deletion
• Ctnnb1^{tm2(Nfkbia)Rsu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKBIA (4792)

  Nfkbia

  (MGI:104741)

• Mutation details: This allele is similar to Catnnb1^{tm1(Nfkbia)Rsu} in that an Nfkbia cDNA encoding amino acids 71 through 317 was inserted at the start codon of Catnnb1, but in this case, a floxed stop cassette preceded the Nfkbia sequence, precluding its expression. As in Catnnb1^{tm1(Nfkbia)Rsu}, the coding region of the first coding exon and the following 4 downstream exons were deleted. (J:71744)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:71744 Schmidt-Ullrich R, et al., Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53
• All: 13 reference(s)