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Cxcr4tm2Yzo
Targeted Allele Detail
Summary
Symbol: Cxcr4tm2Yzo
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 2, Yong-Rui Zou
MGI ID: MGI:3525214
Synonyms: Cxcr4f, Cxcr4loxP
Gene: Cxcr4  Location: Chr1:128515936-128520030 bp, - strand  Genetic Position: Chr1, 56.43 cM
Alliance: Cxcr4tm2Yzo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94911
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene flanked by loxP sites was inserted into intron 1 and a third loxP site was introduced into exon 2. Crossing with EIIa-cre mice resulted in the excision of the neo, leaving exon 2 flanked with loxP sites. (J:94911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Cxcr4tm2Yzo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  32 strains or lines available
References
Original:  J:94911 Nie Y, et al., The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 2004 Nov 1;200(9):1145-56
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/31/2023
MGI 6.22
The Jackson Laboratory