Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Cxcr4tm2Yzo mutation
(1 available);
any
Cxcr4 mutation
(40 available)
Tg(Wap-cre)11738Mam mutation
(3 available)
Tg(Wap-Hgf)402Mig mutation
(1 available)
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neoplasm
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• tumors are smaller in females 2 weeks postpartum than in triple mutants
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endocrine/exocrine glands
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• tumors are smaller in females 2 weeks postpartum than in triple mutants
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integument
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• tumors are smaller in females 2 weeks postpartum than in triple mutants
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hematopoietic system
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• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes
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immune system
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• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes
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hematopoietic system
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• B cell precursors are found in the blood
• a large number of the B cell precursors die before they can complete the differentiation process
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• the total number of mature B cells in the spleen is reduced to about 65% of wild-type
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• the peritoneal B1 cell population is reduced in young and old mutants
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• the peritoneal B2 cell population is reduced only in older mutants
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• a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
• the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
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• basal levels of serum IG of all isotypes are reduced
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immune system
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• B cell precursors are found in the blood
• a large number of the B cell precursors die before they can complete the differentiation process
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• the total number of mature B cells in the spleen is reduced to about 65% of wild-type
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• the peritoneal B1 cell population is reduced in young and old mutants
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• the peritoneal B2 cell population is reduced only in older mutants
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• a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
• the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
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• basal levels of serum IG of all isotypes are reduced
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• B cell follicles are more dispersed, frequently occur deep in the lamina propria, and some have enlarged T cell zones
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immune system
adipose tissue
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N |
• mice fed standard chow or a high-fat diet exhibit normal adiposity and lymphocyte numbers in white adipose tissue
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growth/size/body
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N |
• mice fed standard chow or a high-fat diet exhibit normal weight gain
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hematopoietic system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm2Yzo mutation
(1 available);
any
Cxcr4 mutation
(40 available)
Tg(Fabp4-cre)1Rev mutation
(2 available)
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adipose tissue
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• 1.8-fold in mice fed a high-fat diet
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• 2-fold increase in mice fed a high-fat diet
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• 2-fold in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• in mice fed a high-fat diet
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homeostasis/metabolism
immune system
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• in the white adipose tissue of mice fed a high-fat diet
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• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
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• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
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• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
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growth/size/body
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N |
• mice fed standard chow or a high-fat diet exhibit normal lean mass
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• in mice fed a high-fat diet despite normal food intake
• however, mice fed standard chow exhibit normal weight
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hematopoietic system
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• in the white adipose tissue of mice fed a high-fat diet
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• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
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• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
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• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
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integument
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• 1.8-fold in mice fed a high-fat diet
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm2Yzo mutation
(1 available);
any
Cxcr4 mutation
(40 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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mortality/aging
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• most mice die between 12-14 months of age
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cardiovascular system
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• at 6 months, but not 2 months, mice show progressive interstitial/perivascular fibrosis
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• hearts from 5-month-old mice have a higher number of mitochondria and these mitochondria are smaller than in controls
• however, stroke volume and cardiac output are normal and heart rate is not significantly affected
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• at 6 months, but not 2 months, hearts show significant cardiac myocyte hypertrophy
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• by 6 months of age, mice have a 15% increase in heart weight to body weight ratio and a 50% increase by 12 months of age
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• at 6 months, but not 2 months, hearts show significant cardiac myocyte hypertrophy
• 4-month-old mice show elevated levels of atrial natriuretic factor (ANF), a maker of cardiac hypertrophy
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• at 6 months, but not 2 months, mice show progressive interstitial/perivascular fibrosis
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• 12-month-old mice exhibit a 3-fold decline in the maximum rate of change in left ventricular pressure (dp/dt max) and a more than 2.5-fold decline in ejection fraction
• 4-month-old mice exhibit a 2.5-fold decrease in contractility and a significant decrease in ejection fraction
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• mice show an increase in left ventricular end-diastolic volume and an increase in end-systolic volume, indicating a decline in systolic pressures over time
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• mice develop progressive cardiomyopathy, showing mild cardiomyopathy as early as 4 months of age
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• progressive cardiac dysfunction leads to clinical hear failure by 12 months of age
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growth/size/body
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• by 6 months of age, mice have a 15% increase in heart weight to body weight ratio and a 50% increase by 12 months of age
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• at 6 months, but not 2 months, hearts show significant cardiac myocyte hypertrophy
• 4-month-old mice show elevated levels of atrial natriuretic factor (ANF), a maker of cardiac hypertrophy
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homeostasis/metabolism
muscle
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• at 6 months, but not 2 months, hearts show significant cardiac myocyte hypertrophy
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• 12-month-old mice exhibit a 3-fold decline in the maximum rate of change in left ventricular pressure (dp/dt max) and a more than 2.5-fold decline in ejection fraction
• 4-month-old mice exhibit a 2.5-fold decrease in contractility and a significant decrease in ejection fraction
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• mice develop progressive cardiomyopathy, showing mild cardiomyopathy as early as 4 months of age
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cellular
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• at 6 months, but not 2 months, mice show progressive interstitial/perivascular fibrosis
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Analysis Tools