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Ctnnb1 Gene Detail
Summary
  • Symbol
    Ctnnb1
  • Name
    catenin beta 1
  • Synonyms
    beta catenin, beta-catenin, Bfc, catenin (cadherin associated protein), beta 1, Catnb
Location &
Maps
more
  • Sequence Map
    Chr9:120762466-120789573 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88276
 protein coding gene Chr9:120758282-120789573 (+)
129S1/SvImJ ENSMUSG00200030431
 protein coding gene Chr9:117905647-117915981 (+)
A/J ENSMUSG00195025307
 protein coding gene Chr9:117080615-117090949 (+)
AKR/J ENSMUSG00220018179
 protein coding gene Chr9:117549225-117559559 (+)
BALB/cJ ENSMUSG00180026866
 protein coding gene Chr9:117617880-117628214 (+)
C3H/HeJ ENSMUSG00175017184
 protein coding gene Chr9:117861124-117871458 (+)
C57BL/6NJ ENSMUSG00215020724
 protein coding gene Chr9:117736715-117747049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032821
 protein coding gene Chr9:116330829-116362023 (+)
CAST/EiJ ENSTCUG00005015218
 protein coding gene Chr9:117477863-117488202 (+)
CBA/J ENSMUSG00210033135
 protein coding gene Chr9:117588008-117598342 (+)
DBA/2J ENSMUSG00185014477
 protein coding gene Chr9:117922242-117932576 (+)
FVB/NJ ENSMUSG00205016454
 protein coding gene Chr9:117749356-117759690 (+)
JF1/MsJ ENSUMUG00000032325
 protein coding gene Chr9:117759822-117770172 (+)
LP/J ENSMUSG00230031987
 protein coding gene Chr9:118033892-118044226 (+)
NOD/ShiLtJ ENSMUSG00190014733
 protein coding gene Chr9:117514990-117525351 (+)
NZO/HlLtJ ENSMUSG00225022411
 protein coding gene Chr9:118298198-118308532 (+)
PWK/PhJ ENSLUMG00010030231
 protein coding gene Chr9:117645268-117655611 (+)
SPRET/EiJ ENSMSPG00010021028
 protein coding gene Chr9:119344131-119354480 (+)
WSB/EiJ ENSIUOG00005018504
 protein coding gene Chr9:116960671-116971026 (+)



Homology
more
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNB1, catenin beta 1
  • Synonyms
    armadillo, CTNNB, EVR7, MRD19, NEDSDV
  • Links
    NCBI Gene ID: 1499
    UniProt: P35222

  • Chr Location
    3p22.1; chr3:41194741-41260096 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with Ctnnb1 mouse models; 9 with human CTNNB1 associations

Human Disease Mouse Models
      
IDs
 View 6 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 6 models
IDs
 View 2 models
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    14 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    358 phenotypes from 17 alleles in 65 genetic backgrounds
    254 phenotypes from multigenic genotypes
    6 images
    1180 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc. Inducible KO in endothelial cells affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    559
  • GO References
    259
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2782
  • Tissues
    866
  • cDNA Data
    975
  • Literature Summary
    1233
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12387 NCBI Gene Model | MGI Sequence Detail 27108 C57BL/6J ±  kb
    transcript NM_001431672 RefSeq | MGI Sequence Detail 3543 C57BL/6  
    polypeptide Q02248 UniProt | EBI | MGI Sequence Detail 781 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1021
      cDNA 978
      Primer pair 36
      Other 7
      Antibodies 145

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1775, MGI:2656732
    References
    more
    • Summaries
      All 3265
      Developmental Gene Expression 1233
      Diseases 14
      Gene Ontology 259
      Phenotypes 1180
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:391571 Kumari G, et al., beta-catenin-driven innate and metabolic reprograming in macrophages fuel T-cell-dependent inflammation in Toxoplasma gondii infection: implications for therapeutic intervention. Cell Death Dis. 2026 Jun 13;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory