Apc
Gene Detail

Symbol Name ID

Apc adenomatosis polyposis coli MGI:88039

Synonyms

CC1, Min

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr18:34220924-34318608 bp, + strand From VEGA annotation of GRCm38   97685 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenomatous polyposis coli protein
Gene Tree: Apc

Human homologs

Human Homolog		APC, adenomatous polyposis coli
NCBI Gene ID		324
neXtProt AC		NX_P25054
Human Synonyms		BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
Human Chr (Location)		5q21-q22; chr5:112043202-112181936 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human APC

Alleles and phenotypes

All alleles(88) : Targeted(25) Gene trapped(62) Chemically induced(1)
 

Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.

 
Human Diseases Modeled Using Mouse Apc (3)    Alleles Annotated to Human Diseases(7)    Phenotype Images(10)

Gene Ontology (GO) classifications

All GO classifications: (182 annotations)

Process	anterior/posterior pattern specification, axis specification, ...
Component	axonal growth cone, axon part, ...
Function	beta-catenin binding, gamma-catenin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (281)    Tissues (128)    Images (48)
Theiler Stages: 19, 20, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	231
RT-PCR	47

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(1) cDNA(32) Primer pair(7) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000035932 (Evidence)
Ensembl Gene Model	ENSMUSG00000005871 (Evidence)
Entrez Gene	11789 (Evidence)
DFCI	TC1588179, TC1592394, TC1597237, TC1602812, TC1612444, TC1631288, TC1651499, TC1678384
DoTS	DT.101156961, DT.101187621, DT.485678, DT.91297212, DT.91401983, DT.94179295, DT.94237223, DT.94359608
NIA Mouse Gene Index	U018534, U043657, U052693
PDB	1VJ6
Consensus CDS Project	CCDS29125.1
International Mouse Knockout Project Status	Apc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035932	VEGA Gene Model | MGI Sequence Detail	97685	C57BL/6J
transcript	OTTMUST00000092329	VEGA | MGI Sequence Detail	8867	Not Applicable
polypeptide	OTTMUSP00000051004	VEGA | MGI Sequence Detail	2842	Not Applicable

All sequences(89) RefSeq(2) UniProt(11)

Polymorphisms

All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs(452 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026831	Adenomatous polyposis coli domain
InterPro	IPR026836	Adenomatous polyposis coli protein
InterPro	IPR009240	Adenomatous polyposis coli protein, 15 residue repeat
InterPro	IPR009234	Adenomatous polyposis coli protein basic domain
InterPro	IPR009223	Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro	IPR026818	Adenomatous polyposis coli protein family
InterPro	IPR000225	Armadillo
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR009232	EB-1 binding
InterPro	IPR009224	SAMP
Protein Ontology	PR:000004122	adenomatous polyposis coli protein

References

(Earliest) J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51:228-230
(Latest) J:195273 Qian Y, et al., Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development. 2013 Apr;140(8):1751-61
All references(847)

Other accession IDs

MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352