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Apc
Gene Detail
Symbol

Name
ID
Apc
adenomatosis polyposis coli
MGI:88039
Synonyms
CC1, Min
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr18:34220924-34318608 bp, + strand
From VEGA annotation of GRCm38

  97685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: APC
Protein SuperFamily: adenomatous polyposis coli protein
Gene Tree: Apc

Human
homologs
APC, adenomatous polyposis coli
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 324
neXtProt AC: NX_P25054

Human Synonyms: BTPS2, DP2, DP2.5, DP3, GS, PPP1R46

Human Chr (Location): 5q21-q22; chr5:112707505-112846239 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human APC

Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Chemically induced (ENU)(2) Gene trapped(62) Targeted(25)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
 
Human Diseases Modeled in Mice Using Apc (6)    Mutations Annotated to Human Diseases (10)    Phenotype Images(16)
Interactions
Apc interacts with 486 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (186 annotations)
Process anterior/posterior pattern specification, axis specification, ...
Component axon, axonal growth cone, ...
Function beta-catenin binding, gamma-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (283)    Tissues (129)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 231
RT-PCR 47
cDNA source data(226)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apc ; ZFIN apc    NEW 
Molecular
reagents
All nucleic(239) Genomic(1) cDNA(230) Primer pair(7) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000035932 (Evidence)
Ensembl Gene Model ENSMUSG00000005871 (Evidence)
Entrez Gene 11789 (Evidence)
UniGene 384171
DFCI TC1588179, TC1592394, TC1597237, TC1602812, TC1612444, TC1631288, TC1651499, TC1678384
DoTS DT.101156961, DT.101187621, DT.485678, DT.91297212, DT.91401983, DT.94179295, DT.94237223, DT.94359608
NIA Mouse Gene Index U018534, U043657, U052693
PDB 1VJ6
Consensus CDS Project CCDS29125.1
International Mouse Phenotyping Consortium Status Apc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035932 VEGA Gene Model | MGI Sequence Detail 97685 C57BL/6J ±  kb
transcript OTTMUST00000092329 VEGA | MGI Sequence Detail 8867 Not Applicable 
polypeptide OTTMUSP00000051004 VEGA | MGI Sequence Detail 2842 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(22) UniProt(12)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(551 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026836 Adenomatous polyposis coli
InterPro IPR026818 Adenomatous polyposis coli (APC) family
InterPro IPR026831 Adenomatous polyposis coli domain
InterPro IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
InterPro IPR009234 Adenomatous polyposis coli protein basic domain
InterPro IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR009232 EB-1 binding
InterPro IPR009224 SAMP
Protein Ontology PR:000004122 adenomatous polyposis coli protein
References
(Earliest) J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51:228-230
(Latest) J:221412 Maywald RL, et al., IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2487-96
All references(1023)
Disease annotation references (31)
Other
accession IDs
MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory