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Apc
Gene Detail
 Symbol
Name
ID
Apc
adenomatosis polyposis coli
MGI:88039
Synonyms CC1, Min
Feature Type protein coding gene
Genetic Map
Chromosome 18
18.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr18:34220924-34318608 bp, + strand
From VEGA annotation of GRCm38

  97685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenomatous polyposis coli protein
Gene Tree: Apc

Human
homologs
Human Homolog APC, adenomatous polyposis coli
NCBI Gene ID 324
neXtProt AC  NX_P25054
Human Synonyms  BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
Human Chr (Location)  5q21-q22; chr5:112707505-112846239 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human APC
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Chemically induced (ENU)(1) Gene trapped(62) Targeted(25)
Incidental mutations (data from Mutagenetix , APF )
 
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
 
Human Diseases Modeled Using Mouse Apc (5)    Alleles Annotated to Human Diseases(9)    Phenotype Images(16)
Interactions
Apc interacts with 487 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (185 annotations)
Process anterior/posterior pattern specification, axis specification, ...
Component axon, axonal growth cone, ...
Function beta-catenin binding, gamma-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (281)    Tissues (128)    Images (48)
Theiler Stages: 19, 20, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 231
RT-PCR 47
cDNA source data(226)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(239) Genomic(1) cDNA(230) Primer pair(7) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000035932 (Evidence)
Ensembl Gene ModelENSMUSG00000005871 (Evidence)
Entrez Gene11789 (Evidence)
UniGene384171
DFCITC1588179, TC1592394, TC1597237, TC1602812, TC1612444, TC1631288, TC1651499, TC1678384
DoTSDT.101156961, DT.101187621, DT.485678, DT.91297212, DT.91401983, DT.94179295, DT.94237223, DT.94359608
NIA Mouse Gene IndexU018534, U043657, U052693
PDB1VJ6
Consensus CDS ProjectCCDS29125.1
International Mouse Knockout Project StatusApc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035932 VEGA Gene Model | MGI Sequence Detail 97685 C57BL/6J ±  kb
transcript OTTMUST00000092329 VEGA | MGI Sequence Detail 8867 Not Applicable 
polypeptide OTTMUSP00000051004 VEGA | MGI Sequence Detail 2842 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(24) UniProt(12)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(551 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026836 Adenomatous polyposis coli
InterPro IPR026818 Adenomatous polyposis coli (APC) family
InterPro IPR026831 Adenomatous polyposis coli domain
InterPro IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
InterPro IPR009234 Adenomatous polyposis coli protein basic domain
InterPro IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR009232 EB-1 binding
InterPro IPR009224 SAMP
Protein Ontology PR:000004122 adenomatous polyposis coli protein
References (Earliest) J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51:228-230
(Latest) J:211668 Cordero JB, et al., c-Src drives intestinal regeneration and transformation. EMBO J. 2014 Jul 1;33(13):1474-91
All references(972)
Disease annotation references (21)
Other
accession IDs
MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory