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Apc Gene Detail
Summary
  • Symbol
    Apc
  • Name
    adenomatosis polyposis coli
  • Synonyms
    CC1, Min
  • Feature Type
    protein coding gene
  • IDs
    MGI:88039
    NCBI Gene: 11789
  • Gene Overview
    MyGene.info: APC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:34220924-34318608 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      97685 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.53 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    APC, APC, WNT signaling pathway regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APC, APC, WNT signaling pathway regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
  • Links
    NCBI Gene ID: 324
    neXtProt AC: NX_P25054
    UniProt: P25054

  • Chr Location
    5q22.2; chr5:112707505-112846239 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    6 with Apc mouse models; 4 with human APC associations

Human Disease Mouse Models
      
IDs
View 10 models
IDs
View 10 models
IDs
View 1 model
      
IDs
View 2 models
IDs
View 2 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    29 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    225 phenotypes from 26 alleles in 55 genetic backgrounds
    147 phenotypes from multigenic genotypes
    23 images
    1100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035932 VEGA Gene Model | MGI Sequence Detail 97685 C57BL/6J ±  kb
    transcript OTTMUST00000092329 VEGA | MGI Sequence Detail 8867 Not Applicable  
    polypeptide OTTMUSP00000051004 VEGA | MGI Sequence Detail 2842 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      553 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 242
      Genomic 1
      cDNA 232
      Primer pair 8
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352
    References
    more
    • Summaries
      All 1274
      Developmental Gene Expression 70
      Diseases 29
      Gene Ontology 109
      Phenotypes 1100
    • Earliest
      J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51:228-230
    • Latest
      J:262663 Burke ZD, et al., Spatiotemporal regulation of liver development by the Wnt/beta-catenin pathway. Sci Rep. 2018 Feb 9;8(1):2735

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory