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Apc Gene Detail
Summary
  • Symbol
    Apc
  • Name
    APC, WNT signaling pathway regulator
  • Synonyms
    adenomatosis polyposis coli, CC1, Min
  • Feature Type
    protein coding gene
  • IDs
    MGI:88039
    NCBI Gene: 11789
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34353977-34455605 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.53 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88039
protein coding gene Chr18:34353350-34455605 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024236
protein coding gene Chr18:32422297-32522776 (+)
A/J MGP_AJ_G0024202
protein coding gene Chr18:31322330-31427022 (+)
AKR/J MGP_AKRJ_G0024171
protein coding gene Chr18:32207234-32316309 (+)
BALB/cJ MGP_BALBcJ_G0024202
protein coding gene Chr18:31382720-31489899 (+)
C3H/HeJ MGP_C3HHeJ_G0023970
protein coding gene Chr18:32235351-32341715 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024644
protein coding gene Chr18:33652686-33758150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022085
protein coding gene Chr18:31476837-31579520 (+)
CAST/EiJ MGP_CASTEiJ_G0023445
protein coding gene Chr18:32170740-32277521 (+)
CBA/J MGP_CBAJ_G0023938
protein coding gene Chr18:34568909-34685897 (+)
DBA/2J MGP_DBA2J_G0024070
protein coding gene Chr18:30988456-31091204 (+)
FVB/NJ MGP_FVBNJ_G0024036
protein coding gene Chr18:30677700-30778922 (+)
LP/J MGP_LPJ_G0024151
protein coding gene Chr18:32501654-32606547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024064
protein coding gene Chr18:35879069-35987876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024692
protein coding gene Chr18:32044036-32147453 (+)
PWK/PhJ MGP_PWKPhJ_G0023188
protein coding gene Chr18:31174765-31275552 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022997
protein coding gene Chr18:32316583-32418980 (+)
WSB/EiJ MGP_WSBEiJ_G0023508
protein coding gene Chr18:31968185-32072038 (+)



Homology
more
  • Human Ortholog
    APC, APC regulator of WNT signaling pathway
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APC, APC regulator of WNT signaling pathway
  • Synonyms
    BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46
  • Links
    NCBI Gene ID: 324
    neXtProt AC: NX_P25054
    UniProt: P25054

  • Chr Location
    5q22.2; chr5:112707498-112846239 (+)  GRCh38

Human Diseases
more
  • Diseases
    6 with Apc mouse models; 17 with human APC associations

Human Disease Mouse Models
      
IDs
View 12 models
IDs
View 1 model
IDs
View 1 model
      
IDs
View 2 models
IDs
View 10 models
IDs
View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    30 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    232 phenotypes from 25 alleles in 56 genetic backgrounds
    157 phenotypes from multigenic genotypes
    23 images
    1541 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005871 Ensembl Gene Model | MGI Sequence Detail 101629 C57BL/6J ±  kb
    transcript ENSMUST00000079362 Ensembl | MGI Sequence Detail 12811 Not Applicable  
    polypeptide ENSMUSP00000078337 Ensembl | MGI Sequence Detail 2842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 245
      Genomic 1
      cDNA 232
      Primer pair 10
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352
    References
    more
    • Summaries
      All 1768
      Developmental Gene Expression 115
      Diseases 30
      Gene Ontology 111
      Phenotypes 1541
    • Earliest
      J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51(5):228-230
    • Latest
      J:345288 Tran HT, et al., BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health. Sci Rep. 2024 Feb 15;14(1):3838

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory