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Symbol
Name
ID
Apc
APC, WNT signaling pathway regulator
MGI:88039
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Odontoma
Breast carcinoma
Fibroadenoma of the breast
Colorectal polyposis
Hereditary nonpolyposis colorectal carcinoma
Adenomatous colonic polyposis
Colon cancer
Duodenal polyposis
Neoplasm of the stomach
Multiple gastric polyps
Stomach cancer
Neoplasm of the liver
Hepatoblastoma
Hepatocellular carcinoma
Pancreatic adenocarcinoma
Desmoid tumors
Duodenal adenocarcinoma
Small intestine carcinoid
Adrenocortical adenoma
Adrenocortical carcinoma
Papillary thyroid carcinoma
Prostate cancer
Ovarian carcinoma
Endometrial carcinoma
Uterine leiomyosarcoma
Renal cell carcinoma
Transitional cell carcinoma of the bladder
Multiple lipomas
Osteoma
Astrocytoma
Spinal cord tumor
Medulloblastoma
Cerebellar medulloblastoma
Neuroblastoma
Neoplasm of the lung
Carcinoma
Fibroma
Melanoma
Disease(s) Associated with APC
colorectal cancer
endometrial cancer
familial adenomatous polyposis 1
hepatocellular carcinoma
hereditary desmoid disease
medulloblastoma
pancreatic cancer
prostate cancer
renal cell carcinoma
stomach cancer

Mouse Phenotypes
neoplasm
decreased intestinal adenoma incidence
increased gastrointestinal tumor incidence
increased colon adenoma incidence
increased intestinal adenocarcinoma incidence
increased large intestine adenocarcinoma incidence
increased small intestine adenocarcinoma incidence
increased intestinal adenoma incidence
increased stomach tumor incidence
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
increased ovary tumor incidence
increased granulosa cell tumor incidence
increased prostate gland adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
increased incidence of tumors by chemical induction
increased skin tumor incidence
increased pilomatricoma incidence
increased trichoepithelioma incidence
increased liver tumor incidence
increased hepatocellular carcinoma incidence
abnormal tumor pathology
increased metastatic potential
abnormal tumor morphology
decreased tumor growth/size
increased tumor growth/size
increased adenoma incidence
increased renal cystadenoma incidence
increased desmoid tumor incidence
increased carcinoma incidence
increased osteosarcoma incidence
increased incidence of induced tumors
increased organ/body region tumor incidence
increased reproductive system tumor incidence
increased osteoma incidence
increased tumor incidence
Availability Mouse Genotype
Apctm1Rfo/Apctm1Rfo *
Apctm1Rsmi/Apctm1Rsmi *
Apctm1Tno/Apctm1Tno
ApcGt(XA018)Byg/Apc+ ! !
ApcM1Tno/Apc+
ApcMin/Apc+ * !
Apctm1.1Alew/Apc+
Apctm1.1Rsmi/Apc+
Apctm1.1Tno/Apc+
Apctm1.1Tyj/Apc+
Apctm1Cip/Apc+
Apctm1Mmt/Apc+
Apctm1Rak/Apc+
Apctm1Tno/Apc+
Apctm2.1Alew/Apc+
Apctm2.1Rak/Apc+
Apctm2Mmt/Apc+
Apctm2Rfo/Apc+
Apctm2Tno/Apc+
Apctm3Mmt/Apc+
Apctm4Mmt/Apc+
Apctm1Kk/Apctm1Kk
Tg(Lck-cre)1Cwi/?  (conditional)
Apctm1Rsmi/Apctm1Rsmi
Pgrtm2(cre)Lyd/Pgr+  (conditional)
Apctm1Tno/Apctm1Tno
Tg(CDX2-cre*)189Erf/0  (conditional)
Apctm1Tno/Apctm1Tno
Tg(Cdh16-cre)91Igr/0  (conditional)
Apctm1Tno/Apctm1Tno
Tg(Pbsn-cre)4Prb/0  (conditional)
Apctm1Tno/Apctm1Tno
Lgr5tm1(cre/ERT2)Cle/Lgr5+  (conditional)
Apctm2.1Cip/Apctm2.1Cip  (conditional)
Apctm2Rak/Apctm2Rak
Tg(Car1-cre)5Flt/0  (conditional)
Apctm2Rak/Apctm2Rak  (conditional)
Apctm1Rsmi/Apc+
Tg(Fabp1-cre)1Jig/0  (conditional)
Apctm1Tno/Apc+
Tg(CDX2-cre*)189Erf/0  (conditional)
*
Apctm1Tno/Apc+
Tg(CDX2-cre)101Erf/0  (conditional)
Apctm1Tno/Apc+
Tg(Vil1-cre)997Gum/0  (conditional)
Apctm1Tno/Apc+
Tg(CDX2-cre/ERT)#Erf/0  (conditional)
Apctm1Tyj/Apc+
Tg(Vil1-cre)20Syr/0  (conditional)
Apctm2.1Cip/Apc+
Tg(Fabp1-cre)1Jig/0  (conditional)
Apctm2.1Cip/Apc+
Tg(Vil1-cre)20Syr/0  (conditional)
Apctm2.1Cip/Apc+
Lrig1tm1.1(cre/ERT2)Rjc/Lrig1+  (conditional)
Apctm2.1Cip/Apc+
Lgr5tm1(cre/ERT2)Cle/Lgr5+  (conditional)
*
Apctm2.1Cip/Apc+
Tg(Vil1-cre/ERT2)23Syr/0  (conditional)
Apctm2Rak/Apc+
Tg(Car1-cre)5Flt/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory