Phenotypes Associated with This Genotype

Genotype
MGI:3522324

• Allelic Composition: Apc^tm2.1Cip/Apc^tm2.1Cip
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94721 )

• injection with 10⁹ pfu adenovirus cre resulted in 50% mortality within 2 weeks and 95% mortality within 2 months

• lower doses of adenovirus cre resulted in decreased mortality (15% mortality at 2 months with 0.5 x 10⁹ pfu) or no mortality (0.25 x 10⁹ pfu)

neoplasm

increased hepatocellular carcinoma incidence ( J:94721 )

• 9 months after injection with 0.5 x 10⁹ pfu adenovirus cre of the 4 out of 6 livers that still contained hepatocytes with the recombined allele developed micronodular preneoplastic foci and/or hepatocellular carcinomas

liver/biliary system

liver hyperplasia ( J:94721 )

• 7 days after injection with 10⁹ pfu of adenovirus cre the livers of homozygous mutants were 60% larger than heterozygous controls

• hepatocytes containing the recombined allele are selectively lost over time, 9 months after injection with 0.5 x 10⁹ pfu adenovirus cre 6 out of 10 livers still contained hepatocytes with the recombined allele

increased hepatocellular carcinoma incidence ( J:94721 )

• 9 months after injection with 0.5 x 10⁹ pfu adenovirus cre of the 4 out of 6 livers that still contained hepatocytes with the recombined allele developed micronodular preneoplastic foci and/or hepatocellular carcinomas

growth/size/body

liver hyperplasia ( J:94721 )

• 7 days after injection with 10⁹ pfu of adenovirus cre the livers of homozygous mutants were 60% larger than heterozygous controls

• hepatocytes containing the recombined allele are selectively lost over time, 9 months after injection with 0.5 x 10⁹ pfu adenovirus cre 6 out of 10 livers still contained hepatocytes with the recombined allele

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:94721