Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to integument

Darker colors indicate more annotations

Human Phenotypes	Breast carcinoma	Fibroadenoma of the breast	Jaundice	Hyperpigmentation of the skin	Keloids	Epidermoid cyst
Disease(s) Associated with APC	Breast carcinoma	Fibroadenoma of the breast	Jaundice	Hyperpigmentation of the skin	Keloids	Epidermoid cyst
familial adenomatous polyposis 1
hereditary desmoid disease
pancreatic cancer

Mouse Phenotypes

abnormal keratinocyte differentiation

increased forehead pigmentation

increased ear pigmentation

abnormal mammary gland development

absent nipple

increased mammary gland tumor incidence

increased mammary adenocarcinoma incidence

mammary gland hyperplasia

absent male preputial gland

skin cyst

epidermal cyst

delayed hair appearance

short hair

abnormal hair follicle morphology

abnormal hair follicle bulb morphology

abnormal hair follicle development

underdeveloped hair follicles

abnormal hair follicle orientation

short vibrissae

blistering

scaly skin

skin ridges

wrinkled skin

abnormal skin pigmentation

increased skin tumor incidence

increased pilomatricoma incidence

increased trichoepithelioma incidence

Availability

Mouse Genotype

Apc^tm1Rfo/Apc^tm1Rfo

Apc^M1Tno/Apc⁺

Apc^Min/Apc⁺

Apc^tm1.1Rsmi/Apc⁺

Apc^tm1Cip/Apc⁺

Apc^tm1Rak/Apc⁺

Apc^tm2Rfo/Apc⁺

Apc^tm1Rsmi/Apc^tm1Rsmi
Tg(Col2a1-cre)1Rsjo/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(KRT14-cre)8Brn/0 (conditional)

Apc^tm1Tno/Apc⁺
Tg(CDX2-cre)101Erf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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