Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

cellular phenotype

abnormal intestinal goblet cell morphology

aneuploidy

abnormal cell physiology

abnormal autophagy

increased apoptosis

increased small intestinal crypt cell apoptosis

abnormal keratinocyte differentiation

enhanced osteoblast differentiation

abnormal cell proliferation

abnormal enterocyte proliferation

increased cell proliferation

Availability

Mouse Genotype

Apc^Min/Apc^Min

Apc^tm1.1Klne/Apc^tm1.1Klne

Apc^tm1Rfo/Apc^tm1Rfo

Apc^Min/Apc⁺

Apc^Min/Apc^tm1.1Klne

Apc^tm1.1Alew/Apc⁺

Apc^tm1Rsmi/Apc^tm1Rsmi
Tg(Col2a1-cre)1Rsjo/0 (conditional)

Apc^tm2.1Cip/Apc^tm2.1Cip
Tg(Vil1-cre/ERT2)23Syr/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(KRT14-cre)8Brn/0 (conditional)

Apc^tm2.1Cip/Apc⁺
Tg(Vil1-cre/ERT2)23Syr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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