Excel File Text File All mouse models of central nervous system cancer with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      atypical teratoid rhabdoid tumor Smarcb1tm1Gvk/Smarcb1tm1Gvk involves: 129/Sv * C57BL/6J * SJL/J J:101185 View
atypical teratoid rhabdoid tumor Smarcb1tm1Sho/Smarcb1+ involves: 129S6/SvEvTac * C57BL/6J * DBA/2J J:120820 View
atypical teratoid rhabdoid tumor Smarcb1tm1Sho/Smarcb1+
Tg(LPV-TAg121)2Tvd/0
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J J:120820 View
      glioblastoma Trp53tm1Elee/Trp53tm1Tyj
Tg(GFAP-cre)25Mes/0
involves: 129S2/SvPas * 129S4/SvJae * FVB/N J:149662 View
glioblastoma Nf1tm1Fcr/Nf1tm1Fcr
Trp53tm1Elee/Trp53tm1Elee
Tg(GFAP-cre)25Mes/0
involves: 129S/SvEv * 129S4/SvJae * FVB/N J:149662 View
malignant astrocytoma Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu involves: 129S1/Sv * 129X1/SvJ * ICR J:69129 View
medulloblastoma Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
B6.Cg-Tg(GFAP-tTA)67Pop Tg(tetO-Ifng)184Pop J:94092 View
medulloblastoma Tg(Neurod2-Smo*A1)199Jols/0 C57BL/6-Tg(Neurod2-Smo*A1)199Jols J:93861 View
medulloblastoma Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols C57BL/6-Tg(Neurod2-Smo*A1)199Jols J:189258 View
medulloblastoma Tg(Neurod2-Smo*A2)#Jols/0 C57BL/6-Tg(Neurod2-Smo*A2)#Jols J:189258 View
medulloblastoma Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129 * 129S2/SvPas * C57BL/6 J:67452 View
medulloblastoma Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * 129X1/SvJ J:139574 View
medulloblastoma Ptch1tm1Zim/Ptch1+ involves: 129 * CD-1 J:79666 View
medulloblastoma Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ J:102702 View
medulloblastoma Cdkn1btm1Mlf/Cdkn1btm1Mlf
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 J:205254 View
medulloblastoma Cdkn1btm1Mlf/Cdkn1b+
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 J:205254 View
medulloblastoma Ptch1tm1Mps/Ptch1+ involves: 129S1/Sv * 129X1/SvJ J:144811 View
medulloblastoma Ptch1tm1Mps/Ptch1+
Ptch2tm1Pmc/Ptch2tm1Pmc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:112118 View
medulloblastoma Ptch1tm1Mps/Ptch1+
Ptch2tm1Pmc/Ptch2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:112118 View
medulloblastoma Ptch1tm1Mps/Ptch1+
Tg(Atoh1-GFP)1Jejo/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 J:144811 View
medulloblastoma Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S/SvEv * C57BL/6 * DBA/2 J:94092 View
medulloblastoma Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre)1Bfri/0
involves: 129T2/SvEms * C57BL/6 * CBA J:139573 View
medulloblastoma Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(GFAP-cre)25Mes/0
involves: 129T2/SvEms * FVB/N J:139573 View
medulloblastoma Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129T2/SvEms * FVB/N J:139573 View
medulloblastoma Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
involves: 129X1/SvJ J:139574 View
medulloblastoma Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(GFAP-cre)25Mes/0
involves: 129X1/SvJ * FVB/N J:139574 View
medulloblastoma Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129X1/SvJ * FVB/N J:139574 View
medulloblastoma Tg(Neurod2-Smo*A1)199Jols/0 involves: C57BL/6 J:221990 View
      familial meningioma Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
involves: 129P2/OlaHsd * FVB/N J:131179 View
medulloblastoma SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 J:173443 View
medulloblastoma Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL J:144617 View
medulloblastoma Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Tyj/Trp53+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL J:144617 View
Transgenes and
Other Mutations
     malignant astrocytoma Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(GFAP-TAg121)1Tvd/0
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N J:99385 View
malignant astrocytoma Tg(GFAP-SRC)1Aag/0 involves: C3H * C57BL/6 J:40335 View
malignant astrocytoma Tg(GFAP-SRC)2Aag/0 involves: C3H * C57BL/6 J:40335 View
malignant astrocytoma Tg(GFAP-TAg121)1Tvd/0 involves: C57BL/6 * DBA/2 * FVB/N J:77132 View
medulloblastoma Tg(tetO-TAg,CMV-rtTA)123Yihu/0 involves: FVB/N J:141623 View
medulloblastoma Tg(Slc1a2-tTA)#Waw/0
Tg(tetO-MYCN,-luc)#Waw/0
involves: FVB/NJ J:160518 View
medulloblastoma Tg(Slc1a2-tTA)#Waw/0
Tg(tetO-MYCN,-luc)#Waw/Tg(tetO-MYCN,-luc)#Waw
involves: FVB/NJ J:160518 View
Additional
Complex
Models
     brain glioma Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N J:285841 View
brain glioma Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N J:285841 View
central nervous system cancer Smarcb1tm2Sho/Smarcb1tm2Sho
Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre)#Gtm/0
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA J:226786 View
glioblastoma proneural subtype Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 J:172585 View
glioblastoma proneural subtype Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 J:172585 View
malignant astrocytoma Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
(C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 J:64364 View
malignant astrocytoma Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
(CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 J:64364 View
malignant astrocytoma Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
(CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 J:64364 View
malignant astrocytoma Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
(SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 J:64364 View
malignant astrocytoma Nf1tm1Tyj/Nf1+
Trp53tm1Tyj/Trp53+
B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ + J:64364 View
malignant astrocytoma Nf1tm1Par/Nf1+
Ptentm1Hwu/Pten+
Trp53tm1Tyj/Trp53+
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N J:134611 View
malignant astrocytoma Nf1tm1Par/Nf1+
Trp53tm1Tyj/Trp53+
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N J:134611 View
malignant astrocytoma Nf1tm1Par/Nf1+
Trp53tm1Elee/Trp53+
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N J:134611 View
medulloblastoma Lig4tm1Icrf/Lig4tm1Icrf
Trp53tm1Tyj/Trp53tm1Tyj
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) J:173443 View
medulloblastoma Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brd/Trp53tm1Brd
Tg(Gfap-cre)2Brn/0
involves: 129 * 129S7/SvEvBrd * FVB/N J:61961 View
medulloblastoma Ptentm2Mak/Ptentm2Mak
Trp53tm1Brn/Trp53tm1Brn
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
involves: 129P2/OlaHsd J:237990 View
medulloblastoma Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL J:102702 View
medulloblastoma Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Gfap-cre)2Brn/0
involves: 129P2/OlaHsd * FVB/N J:61961 View
medulloblastoma Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 J:102702 View
medulloblastoma Cdkn2ctm1Bbd/Cdkn2c+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 J:102702 View
medulloblastoma Trp53tm1Brd/Trp53tm1Brd
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL J:109585 View
medulloblastoma Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL J:141515 View


       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      familial meningioma Nf2tm1Tyj/Nf2+ either: (involves: 129S2/SvPas * 129S4/SvJae * C57BL/6) or (involves: 129S2/SvPas * C57BL/6J) J:47282 View