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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Meox2tm1(cre)Sor
targeted mutation 1, Philippe Soriano
MGI:2176174
Summary 72 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm1Tcs/Capn2tm2.1Tcs
Meox2tm1(cre)Sor/Meox2+
B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc MGI:5292738
cn2
Capn2tm1Tcs/Capn2tm2.1Tcs
Meox2tm1(cre)Sor/Meox2+
B6.129S-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor MGI:5292736
cn3
Meox2tm1(cre)Sor/Meox2+
Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor MGI:5634971
cn4
Llgl1tm1Vv/Llgl1tm1Vv
Meox2tm1(cre)Sor/Meox2+
involves: 129 * 129S4/SvJaeSor * C57BL/6J MGI:3040398
cn5
Meox2tm1(cre)Sor/Meox2+
Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor MGI:4882137
cn6
Meox2tm1(cre)Sor/Meox2+
Raf1tm2Bacc/Raf1tm2.1Bacc
involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:3622526
cn7
Fosl2tm2Wag/Fosl2tm2Wag
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:4834996
cn8
Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3056307
cn9
Junbtm3Wag/Junbtm3Wag
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3036219
cn10
Map2k1tm1Bacc/Map2k1tm1.1Bacc
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:5504404
cn11
Lamtor2tm1.1Lah/Lamtor2tm1.1Lah
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712297
cn12
Krastm4Tyj/Kras+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N MGI:3716399
cn13
Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor MGI:3831349
cn14
Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
involves: 129S1/Sv * 129S4/SvJaeSor MGI:3715229
cn15
Meox2tm1(cre)Sor/Meox2+
Pcsk5tm2Prat/Pcsk5tm2.1Prat
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3797216
cn16
Braftm1Sva/Braftm1.1Sva
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3622484
cn17
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3769399
cn18
Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3769401
cn19
Meox2tm1(cre)Sor/Meox2+
Tead4tm1Bnno/Tead4tm1Bnno
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:3763369
cn20
Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7 MGI:5431828
cn21
Meox2tm1(cre)Sor/0
Pcsk5tm2Prat/Pcsk5tm2.1Prat
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL MGI:3796238
cn22
Meox2tm1(cre)Sor/Meox2+
Xrcc1tm1Pmc/Xrcc1tm1Pmc
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:4359664
cn23
Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:3715232
cn24
Meox2tm1(cre)Sor/Meox2+
Pak4tm2.1Amin/Pak4tm2.2Amin
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4360348
cn25
Krastm4Tyj/Kras+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * 129S4/SvJaeSor MGI:3716398
cn26
Pkd1tm1Ggg/Pkd1tm2Ggg
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * 129S4/SvJaeSor MGI:4843170
cn27
Meox2tm1(cre)Sor/Meox2+
Slc40a1tm2Nca/Slc40a1tm2Nca
involves: 129S4/SvJae * 129S6/SvEvTac MGI:3771551
cn28
Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * C57BL/6 MGI:4365404
cn29
Meox2tm1(cre)Sor/?
Nrastm1Zhng/Nrastm1Zhng
involves: 129S4/SvJae * C57BL/6 MGI:5284827
cn30
Ets2tm3Rgo/Ets2tm3.1Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3615252
cn31
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3615263
cn32
Meox2tm1(cre)Sor/Meox2+
Thoc1tm2.1Dwg/Thoc1tm2.1Dwg
involves: 129S4/SvJae * C57BL/6J MGI:3698529
cn33
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor MGI:4831006
cn34
Efnb1tm1Sor/Efnb1tm1Sor
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor MGI:3719100
cn35
Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor MGI:3719103
cn36
Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor MGI:3719101
cn37
Zfxtm1.1Reiz/Y
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:3848802
cn38
Zfxtm1.1Reiz/Zfxtm1.1Reiz
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:3848808
cn39
Meox2tm1(cre)Sor/Meox2+
Ptpn11tm6Bgn/Ptpn11+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:3840253
cn40
Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:3706134
cn41
Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3776851
cn42
Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702949
cn43
Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6 MGI:3702950
cn44
Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:3831370
cn45
Cubntm1Rkoz/Cubntm1Rkoz
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:4831007
cn46
Cubntm1Rkoz/Cubntm1Rkoz
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:4831005
cn47
Dab2tm2.1Xxx/Dab2tm2.2Xxx
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:5562565
cn48
Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:3719102
cn49
Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:3719099
cn50
Dab2tm1Cpr/Dab2tm1.1Cpr
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:3510687
cn51
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:5140922
cn52
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:5140924
cn53
Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:5140927
cn54
Nrastm1Tyj/Nras+
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6 MGI:5284833
cn55
Meox2tm1(cre)Sor/Meox2+
Rasgrf1tm4.1Pds/Rasgrf1+
involves: 129S4/SvJaeSor * C57BL/6 MGI:3698139
cn56
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:5644692
cn57
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:5644693
cn58
Atmtm2Pmc/Atmtm2Pmc
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6J MGI:5316229
cn59
Meox2tm1(cre)Sor/Meox2+
Sec24ctm1c(EUCOMM)Wtsi/Sec24ctm1c(EUCOMM)Wtsi
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5896387
cn60
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
involves: 129S4/SvJaeSor * FVB/N MGI:3615265
cn61
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
involves: 129S4/SvJaeSor * FVB/N MGI:3615264
cn62
Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt
Meox2tm1(cre)Sor/Meox2+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4843164
cn63
Meox2tm1(cre)Sor/Meox2+
Nodaltm1Rob/Nodaltm5Rob
involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:3056368
cn64
Meox2tm1(cre)Sor/Meox2+
Mfn1tm2Dcc/Mfn1+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss MGI:3779089
cn65
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm3Dcc/Mfn2+
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss MGI:3779087
cn66
Meox2tm1(cre)Sor/Meox2+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss MGI:3779093
cn67
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss MGI:3779086
cn68
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss MGI:3779088
cn69
Meox2tm1(cre)Sor/Meox2+
Smad1tm2Rob/Smad1tm2Sor
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:4437795
cn70
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353414
cn71
Mef2dtm3Eno/Mef2dtm3Eno
Meox2tm1(cre)Sor/Meox2+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * SJL MGI:3777090
cn72
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353413


Genotype
MGI:5292738
cn1
Allelic
Composition
Capn1tm1Ahc/Capn1tm1Ahc
Capn2tm1Tcs/Capn2tm2.1Tcs
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1tm1Ahc mutation (1 available); any Capn1 mutation (23 available)
Capn2tm1Tcs mutation (1 available); any Capn2 mutation (2 available)
Capn2tm2.1Tcs mutation (1 available); any Capn2 mutation (2 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about half survive to adulthood




Genotype
MGI:5292736
cn2
Allelic
Composition
Capn2tm1Tcs/Capn2tm2.1Tcs
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
B6.129S-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2tm1Tcs mutation (1 available); any Capn2 mutation (2 available)
Capn2tm2.1Tcs mutation (1 available); any Capn2 mutation (2 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about half survive to adulthood




Genotype
MGI:5634971
cn3
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic
Background
B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Ptrh2tm1.1Eruo mutation (0 available); any Ptrh2 mutation (33 available)
Ptrh2tm1Eruo mutation (1 available); any Ptrh2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• progressive age related relative decrease in length and weight

nervous system
• slightly but significantly decreased at P7
• neuron soma size is reduced in the cerebral cortex
• cerebellar atrophy at P7

endocrine/exocrine glands
• reduced cross section areas of the pancreatic acini at P7
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini

behavior/neurological
• severe at P7

muscle
• decreased myocyte soma size

liver/biliary system
• decreased soma size

digestive/alimentary system
• reduced cross section areas of the pancreatic acini at P7
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini




Genotype
MGI:3040398
cn4
Allelic
Composition
Llgl1tm1Vv/Llgl1tm1Vv
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Llgl1tm1Vv mutation (1 available); any Llgl1 mutation (2 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 24 hours after birth

cardiovascular system
• areas affected with rosette-like structures are rich in dilated blood vessels
• moderate hemorrhage in the ventricles of the brain, detected as early as E12.5

craniofacial
• dome-like shape of head

embryo
• the apical-junctional complex in the neuroepithelium of E10.5 mutants is disrupted; pseudostratified neuroepithelium in the wild-type embryos is replaced by stratified neuroepithelium in the mutant
• formation of neuroepithelial rosette-like structures similar to the neuroblastic rosettes in human primitive neuroectodermal tumors

nervous system
• areas affected with rosette-like structures are rich in dilated blood vessels
• moderate hemorrhage in the ventricles of the brain, detected as early as E12.5
• many neural progenitor cells fail to exit the cell cycle and differentiate, and instead, continue to proliferate and die by apoptosis
• neural progenitor cells exhibit a loss of cell polarity
• many neural progenitor cells fail to differentiate, and instead continue to proliferate
• the apical-junctional complex in the neuroepithelium of E10.5 mutants is disrupted; pseudostratified neuroepithelium in the wild-type embryos is replaced by stratified neuroepithelium in the mutant
• formation of neuroepithelial rosette-like structures similar to the neuroblastic rosettes in human primitive neuroectodermal tumors
• newborns develop severe hydrocephalus
• ventricles become dilated by E15.5
• lateral ventricles of newborns appear dilated due to accumulation of cerebrospinal fluid and increasing pressure
• expansion of the striatum region of the brain at E12.5, where the neuroepithelial cell layer extends into the zones normally occupied by differentiating cells and forms aberrant rosette-like structures
• ventricular surface of cerebral cortex is destroyed and the subventricular structures are severely damaged
• overall increase in the neural progenitor cell domain and decrease in the differentiated neuronal cell domain
• overall reduction of in the numbers of differentiated neurons in the striatum region

skeleton
• dome-like shape of head

cellular
• many neural progenitor cells fail to exit the cell cycle and differentiate, and instead, continue to proliferate and die by apoptosis
• neural progenitor cells exhibit a loss of cell polarity
• many neural progenitor cells fail to differentiate, and instead continue to proliferate




Genotype
MGI:4882137
cn5
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Zfp568Gt(P103E09)Wrst mutation (0 available); any Zfp568 mutation (100 available)
Zfp568Gt(RRU161)Byg mutation (0 available); any Zfp568 mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• partial rescue of the null phenotype with some embryos displaying all defects seen in mice homozygous for Zfp568chato, some displaying only the extraembryonic defects, and some having a wild-type phenotype
• the degree of rescue is at least partially related to the degree of cre mediated recombination




Genotype
MGI:3622526
cn6
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Raf1tm2Bacc/Raf1tm2.1Bacc
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Raf1tm2.1Bacc mutation (0 available); any Raf1 mutation (81 available)
Raf1tm2Bacc mutation (0 available); any Raf1 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• live embryos are present at E10.5 but none survive to birth




Genotype
MGI:4834996
cn7
Allelic
Composition
Fosl2tm2Wag/Fosl2tm2Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (5 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• osteoclasts are normal




Genotype
MGI:3056307
cn8
Allelic
Composition
Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation (0 available); any Fosl1 mutation (7 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• deposition of mineralized extracellular matrix is strongly reduced

skeleton
• deposition of mineralized extracellular matrix is strongly reduced
• progressive loss of bone mass
• reduced bone mass is seen in the lumbar vertebral bodies and long bones and vertebral trabecular thickness is reduced in 6 week and 3 month old mutants

cardiovascular system
N
• transaortic constriction of the aorta (TAC) results in a comparable hypertrophic response as in controls

liver/biliary system
N
• in a model of liver fibrosis, mice exhibit a normal response




Genotype
MGI:3036219
cn9
Allelic
Composition
Junbtm3Wag/Junbtm3Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Junbtm3Wag mutation (1 available); any Junb mutation (12 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• myeloproliferative CML-like disease by 3-6 months of age
• massive infiltration of bone marrow and spleen with neutrophilic granulocytes

limbs/digits/tail
• tibia length was reduced by 6 months

skeleton
• 70% reduction in numbers of osteoclasts
• tibia length was reduced by 6 months
• severe osteopenia by 4 weeks of age wihich progressed with age
• bones were thin and brittle by 7 days of age
• by 1 month, vertebral bone mass was decreased
• cortical bone thickness severely reduced at 6 months
• number of osteoblasts is reduced by 7 days
• osteoblast numbers reduced up to 90% by 6 months
• defective osteoclast differentiation
• 60% reduction in cortical bone formation at 1 month, 40% reduction at 3 months
• 70% reduction in trabecular bone formation at 1 month, 30% reduction at 3 months
• bone resorption significantly reduced
• bone strength was significantly reduced

hematopoietic system
• defective osteoclast differentiation
• 70% reduction in numbers of osteoclasts

immune system
• defective osteoclast differentiation
• 70% reduction in numbers of osteoclasts

cellular
• defective osteoclast differentiation




Genotype
MGI:5504404
cn10
Allelic
Composition
Map2k1tm1Bacc/Map2k1tm1.1Bacc
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1tm1.1Bacc mutation (0 available); any Map2k1 mutation (93 available)
Map2k1tm1Bacc mutation (0 available); any Map2k1 mutation (93 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• embryonic lethality observed in Map2k1tm1.1Bacc homozygotes is rescued




Genotype
MGI:3712297
cn11
Allelic
Composition
Lamtor2tm1.1Lah/Lamtor2tm1.1Lah
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamtor2tm1.1Lah mutation (0 available); any Lamtor2 mutation (10 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• with conditional deletion in the epiblast, no homozygous embryos are detected at E10.5




Genotype
MGI:3716399
cn12
Allelic
Composition
Krastm4Tyj/Kras+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (8 available); any Kras mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• lungs at E12.5 show increased branching compared to Kras; Meox2-cre, Spry2-wild-type lungs; bronchi number is increased, but is still less than age-matched wild-type




Genotype
MGI:3831349
cn13
Allelic
Composition
Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (9 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit neuraxis-wide apoptosis during development unlike in wild-type mice




Genotype
MGI:3715229
cn14
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (2 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos survive as late as E9.5 when death occurs due to severe vascular defects

embryo
• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5
• at E9.5, 46% of mutant embryos show reversed axial rotation compared to no control embryos
• at E8.5, poorly formed allantois with failure to fuse dorsally with the chorion is observed; there is a prominent dorsal bulge extruding dorsally. close to primitive streak

cardiovascular system
• at E9.5, some mutant embryos display reversed position of the atrioventricular canal and outflow tract
• in 23% of embryos at E9.5, there is a vertical heart tube with ambiguous looping direction
• at E9.5, in some embryos canal is reversed with outflow tract
• in 40% of mutant embryos, heart looping is reversed, whereas 37% show normal looping and remainder are ambiguous

cellular
• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5




Genotype
MGI:3797216
cn15
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pcsk5tm2.1Prat mutation (0 available); any Pcsk5 mutation (3 available)
Pcsk5tm2Prat mutation (0 available); any Pcsk5 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit an aortic vascular ring
• cardiac malformations
• dextroposition (one of four)

skeleton
• mice exhibit axial and appendicular skeletal defects similar to those in Pcsk5vcc homozygotes
• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

digestive/alimentary system

limbs/digits/tail
• in some mice
• in some mice

respiratory system
• in the left lung

renal/urinary system

nervous system
• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

craniofacial

growth/size/body




Genotype
MGI:3622484
cn16
Allelic
Composition
Braftm1Sva/Braftm1.1Sva
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Sva mutation (0 available); any Braf mutation (13 available)
Braftm1Sva mutation (1 available); any Braf mutation (13 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although born alive death occurs around 21 days of age from aggressive neurodegenerative disease

growth/size/body
• after being born alive, pups show progressive growth retardation




Genotype
MGI:3769399
cn17
Allelic
Composition
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E7.5, yolk sacs are cone-shaped

growth/size/body




Genotype
MGI:3769401
cn18
Allelic
Composition
Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (6 available)
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around mid-gestation




Genotype
MGI:3763369
cn19
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Tead4tm1Bnno/Tead4tm1Bnno
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tead4tm1Bnno mutation (1 available); any Tead4 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no obvious morphological abnormalities




Genotype
MGI:5431828
cn20
Allelic
Composition
Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq1ot1tm2.1Ckan mutation (0 available); any Kcnq1ot1 mutation (0 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• loss of imprinting of ubiquitously imprinted genes when the Kcnq1ot1 allele is inherited paternally
• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally

growth/size/body
• at 4 weeks of age when the Kcnq1ot1 allele is inherited maternally




Genotype
MGI:3796238
cn21
Allelic
Composition
Meox2tm1(cre)Sor/0
Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pcsk5tm2.1Prat mutation (0 available); any Pcsk5 mutation (3 available)
Pcsk5tm2Prat mutation (0 available); any Pcsk5 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryoes that express the cre knock-in allele during development die at birth from respiratory distress

growth/size/body
• E18.5 embryos are smaller than controls

limbs/digits/tail
• E18.5 pups have shortened or absent tails
• E18.5 pups have shortened or absent tails

respiratory system
• pups die at birth from apparent respiratory failure
• the airways and alveoli of E18.5 embryos are collapsed

skeleton
• 18.5 embryos have incomplete closure of the sternum
• 18.5 embryos have an assymmetric fusion of the ribs to the sternum
• 14 of 15 embryos have one to three additional ribs attached to the sternum
• 10 of 15 embryos have 3 to 4 additional thoracic vertebrae, 8 lumbar vertebrae, and only three to nine sacral and caudal vertebrae
• none of the embryos have the normal complement of vertebraes
• ossification is retarded namely in the mandibles, nasal bone, vertebrae and limbs

renal/urinary system
• all E18.5 embryos lack at least one kidney with only 1/6th of the mice having a normal kidney

digestive/alimentary system
• most E18.5 embryos have abdominal herniations

cardiovascular system
• subepidermal hemorrhages occur on the head or along the spine amongst the smallest 18.5 embryos




Genotype
MGI:4359664
cn22
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Xrcc1tm1Pmc/Xrcc1tm1Pmc
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Xrcc1tm1Pmc mutation (1 available); any Xrcc1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• embryos are malformed by E10 with a high index of apoptosis
• embryos are malformed by E10 with a high index of apoptosis

cellular
• embryos are malformed by E10 with a high index of apoptosis




Genotype
MGI:3715232
cn23
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (2 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (2 available)
Snai2tm2Grid mutation (1 available); any Snai2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• double mutants display an open neural tube at E9.5

growth/size/body

nervous system
N
• in E8.5 cranial fold explants cultured for 48 hours, neural crest cell delamination and migration are observed, similar to control explants
• double mutants display an open neural tube at E9.5




Genotype
MGI:4360348
cn24
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pak4tm2.1Amin mutation (1 available); any Pak4 mutation (65 available)
Pak4tm2.2Amin mutation (0 available); any Pak4 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• authors state that mice exhibit the same defects as observed in Pak4tm2.1Amin/Pak4tm2.2Amin Tg(Sox2-cre)1Amc mice
• authors state that mice exhibit the same defects as observed in Pak4tm2.1Amin/Pak4tm2.2Amin Tg(Sox2-cre)1Amc mice




Genotype
MGI:3716398
cn25
Allelic
Composition
Krastm4Tyj/Kras+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (8 available); any Kras mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos are recovered at a lower frequency (15% vs expected 25%) at E13.5

embryo
N
• mutants show normal vascularization of the yolk sac and placental labyrinth
• fetal-derived hematopoietic progenitors form larger CFU-E (colony-forming unit-erythroid) and BFU-E (burst-forming unit-erythroid) colonies compared with controls

cardiovascular system
• excess cushion tissue often leads to obstructed outflow tract
• at E13.5, embryos frequently show double outlet right ventricle
• atrioventricular valve malformations
• all embryonic hearts have prominent septal defects
• heart defects lead to heart failure and death in embryos by ~E14.5
• embryos appear normal at E12.5, but rapidly develop peripheral hemorrhages by E13.5, consistent with heart failure

hematopoietic system
• red blood cells appear immature compared to wild-type and occasionally highly atypical, consisten with a block in erythroid differentiation
• fetal-derived hematopoietic progenitors form larger CFU-E (colony-forming unit-erythroid) and BFU-E (burst-forming unit-erythroid) colonies compared with controls

respiratory system
• defects in lung branching are apparent by E11.5 compared to controls in vivo and in cultured lungs
• decrease in branching is associated with formation of large, fluid-filled sacs rather than normal terminal branches
• at E12.5, mutant lungs exhibit large dilated bronchi whereas wild-type lungs show secondary and tertiary bronchi
• at E14.5, mutants lungs display dilated bronchi and only a few terminal bronchi
• at E14.5, mutants lungs display only a few terminal bronchioles
• at E12.5, lungs exhibit large dilated bronchi; defect is more pronounced at E14.5
• at E12.5, lungs exhibit large dilated bronchi; defect is more pronounced at E14.5

liver/biliary system
• at E12.5 fetal livers show large areas of apoptosis
• at E12.5, fetal livers appear hypocellular

homeostasis/metabolism
• embryos appear normal at E12.5, but rapidly develop edema by E13.5, consistent with heart failure

integument
• embryos appear normal at E12.5, but rapidly develop pallor by E13.5, consistent with heart failure

cellular
• at E12.5 fetal livers show large areas of apoptosis




Genotype
MGI:4843170
cn26
Allelic
Composition
Pkd1tm1Ggg/Pkd1tm2Ggg
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pkd1tm1Ggg mutation (0 available); any Pkd1 mutation (100 available)
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice survive to birth but more than in Pkd1tm1Ggg homozygotes
• mice that are born alive die shortly after birth

embryo
• placental abnormalities observed in Pkd1tm1Ggg homozygotes are partially rescued
• some mice exhibit fewer fetal vessels and more dilated vascular spaces in the placenta compared with wild-type mice
• on average, fetal vessel density in the placenta is decreased compared to in wild-type mice

homeostasis/metabolism

renal/urinary system

respiratory system

cardiovascular system
N
• edematous mice exhibit normal heart morphology
• some mice exhibit fewer fetal vessels and more dilated vascular spaces in the placenta compared with wild-type mice
• on average, fetal vessel density in the placenta is decreased compared to in wild-type mice




Genotype
MGI:3771551
cn27
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Slc40a1tm2Nca mutation (1 available); any Slc40a1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike homozygous null mice, mice with conditional deletion in embryonic tissues that retain expression in the extraembryonic visceral endoderm and in the placenta survive past birth

hematopoietic system
• severe iron deficient anemia
• at 18 - 22 days of age
• hypochromic at P10
• reduced in both mature erythrocytes and reticulocytes at 18 - 22 days of age
• at 18 - 22 days of age
• at P10
• at P10
• at P10 and at P18 - P22
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls

growth/size/body
• apparent within a few days of birth
• difference from controls becomes more prominent with age

homeostasis/metabolism
• significant iron accumulation in duodenal enterocytes at P12
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls
• significant iron accumulation in the Kupffer cells and hepatocytes at P12
• at P18 - P22 iron levels in the liver are reduced by 1.7-fold compared to controls

digestive/alimentary system
• significant iron accumulation in duodenal enterocytes at P12

immune system
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls

liver/biliary system
• significant iron accumulation in the Kupffer cells and hepatocytes at P12
• at P18 - P22 iron levels in the liver are reduced by 1.7-fold compared to controls

integument
• apparent within a few days of birth
• difference from controls becomes more prominent with age




Genotype
MGI:4365404
cn28
Allelic
Composition
Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm2.1Tiw mutation (1 available); any Ern1 mutation (8 available)
Ern1tm2.2Tiw mutation (0 available); any Ern1 mutation (8 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• unlike germline null mice, no placental abnormalities are seen

liver/biliary system
N
• unlike germline null mice, no liver hypoplasia is seen




Genotype
MGI:5284827
cn29
Allelic
Composition
Meox2tm1(cre)Sor/?
Nrastm1Zhng/Nrastm1Zhng
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Nrastm1Zhng mutation (0 available); any Nras mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice develop normally
• mice are tumor free




Genotype
MGI:3615252
cn30
Allelic
Composition
Ets2tm3Rgo/Ets2tm3.1Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3.1Rgo mutation (0 available); any Ets2 mutation (6 available)
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered

endocrine/exocrine glands
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered
• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control

integument
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered
• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control




Genotype
MGI:3615263
cn31
Allelic
Composition
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

neoplasm
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3698529
cn32
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Thoc1tm2.1Dwg/Thoc1tm2.1Dwg
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Thoc1tm2.1Dwg mutation (0 available); any Thoc1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• blastocysts are unable to form outgrowths upon in vitro culture




Genotype
MGI:4831006
cn33
Allelic
Composition
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2tm1Tew mutation (0 available); any Lrp2 mutation (3 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit reduced uptake of intrinsic factor vitamin B12 complex and apoA-I by proximal tubule cells




Genotype
MGI:3719100
cn34
Allelic
Composition
Efnb1tm1Sor/Efnb1tm1Sor
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (14 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than Mendelian ratios of mice are recovered at 2 weeks after birth




Genotype
MGI:3719103
cn35
Allelic
Composition
Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (14 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than Mendelian ratios of mice are recovered at 2 weeks after birth

limbs/digits/tail
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
• Background Sensitivity: on the 129S4/SvJaeSor background defects are restricted to only the last phalange




Genotype
MGI:3719101
cn36
Allelic
Composition
Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (14 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background




Genotype
MGI:3848802
cn37
Allelic
Composition
Zfxtm1.1Reiz/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth




Genotype
MGI:3848808
cn38
Allelic
Composition
Zfxtm1.1Reiz/Zfxtm1.1Reiz
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth




Genotype
MGI:3840253
cn39
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Ptpn11tm6Bgn/Ptpn11+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Ptpn11tm6Bgn mutation (2 available); any Ptpn11 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle

cardiovascular system
• all mice show cardiac defects
• ventricular septal defect




Genotype
MGI:3706134
cn40
Allelic
Composition
Rictortm1.1Mgn/Rictortm1.2Mgn
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Rictortm1.1Mgn mutation (1 available); any Rictor mutation (17 available)
Rictortm1.2Mgn mutation (0 available); any Rictor mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• significantly lower than expected ratio of live embryos were obtained at E13.5 and E17.5, presumed to indicate embryonic lethality




Genotype
MGI:3776851
cn41
Allelic
Composition
Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm2Pzg mutation (0 available); any Espl1 mutation (5 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• lack spermatogonia
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc
• significantly smaller testes at 6 wks of age
• no sign of spermatogenesis detected at 2 wks of age, due to spermatogonia cell depletion
• absence of spermatids in seminiferous tubules
• absence of spermatocytes in seminiferous tubules
• both sexes are sterile

cellular
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
• absence of spermatids in seminiferous tubules
• absence of spermatocytes in seminiferous tubules
• lack spermatogonia
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
• abnormal metaphase configuration of mutant PGCs at 13.5 dpc
• precocious sister chromatid separation and arrest of PGCs in mitosis due to spindle checkpoint activation
• significantly higher mitotic indices in mutant PGCs than controls at 12.5, 13.5, and 14.5 dpc
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc

embryo
• higher levels of activated caspase-3, p53, and Bax in extracts of 13.5 dpc mutant genital ridges than in controls, suggesting p53-related apoptosis of mutant PGCs

endocrine/exocrine glands
• significantly smaller testes at 6 wks of age




Genotype
MGI:3702949
cn42
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Procrtm2Cte/Procrtm2Cte
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Procrtm2Cte mutation (0 available); any Procr mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mutants have slightly increased thrombin-antithrombin (TAT) complex levels
• 2-month old mice show decreased platelet counts compared to wild-type; differences increase and become significant with age

homeostasis/metabolism
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age

immune system
• circulating levels are higher in 2 month old mutants
• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls
• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age




Genotype
MGI:3702950
cn43
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Procrtm1Cte/Procrtm2Cte
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Procrtm1Cte mutation (0 available); any Procr mutation (7 available)
Procrtm2Cte mutation (0 available); any Procr mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no Procr-null, Meox2 heterozygous mice are obtained




Genotype
MGI:3831370
cn44
Allelic
Composition
Procrtm2Cte/Procrtm3Cte
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Procrtm2Cte mutation (0 available); any Procr mutation (7 available)
Procrtm3Cte mutation (0 available); any Procr mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice were born in the expected ratio




Genotype
MGI:4831007
cn45
Allelic
Composition
Cubntm1Rkoz/Cubntm1Rkoz
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cubntm1Rkoz mutation (0 available); any Cubn mutation (5 available)
Lrp2tm1Tew mutation (0 available); any Lrp2 mutation (3 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die shortly after birth, however a few mice live to adulthood

homeostasis/metabolism
• mice exhibit albuminuria to the same extent as conditional homozygous Cubn mice

renal/urinary system
• mice exhibit albuminuria to the same extent as conditional homozygous Cubn mice
• renal morphology is similar to that in single homozygous Lrp2 mice
• absence of uptake of apoA-I by proximal tubule cells




Genotype
MGI:4831005
cn46
Allelic
Composition
Cubntm1Rkoz/Cubntm1Rkoz
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cubntm1Rkoz mutation (0 available); any Cubn mutation (5 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 19% of the expected 25% of mice are observed indicating some lethality

homeostasis/metabolism
• selective daily albumin excretion is increased about 6-fold
• plasma levels of vitamin B12 are severely decreased due to absence of uptake of intrinsic factor vitamin B12 complex in the ileum

renal/urinary system
• selective daily albumin excretion is increased about 6-fold
• mice exhibit a decrease in uptake of albumin and no uptake of intrinsic factor vitamin B12 complex by proximal tubule cells
• however, urinary tubular uptake or excretion of vitamin D-binding protein is not affected




Genotype
MGI:5562565
cn47
Allelic
Composition
Dab2tm2.1Xxx/Dab2tm2.2Xxx
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2tm2.1Xxx mutation (0 available); any Dab2 mutation (3 available)
Dab2tm2.2Xxx mutation (0 available); any Dab2 mutation (3 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable, with about 10% of cells still expressing DAB2 protein




Genotype
MGI:3719102
cn48
Allelic
Composition
Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (14 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than Mendelian ratios of mice are recovered at 2 weeks after birth

limbs/digits/tail
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs

skeleton
• the perichondrium around forming digits is poorly organized




Genotype
MGI:3719099
cn49
Allelic
Composition
Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (14 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background




Genotype
MGI:3510687
cn50
Allelic
Composition
Dab2tm1Cpr/Dab2tm1.1Cpr
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2tm1.1Cpr mutation (0 available); any Dab2 mutation (3 available)
Dab2tm1Cpr mutation (1 available); any Dab2 mutation (3 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Vitamin D binding protein and retinol binding protein found in the urine

renal/urinary system
• Vitamin D binding protein and retinol binding protein found in the urine
• reduced numbers of coated pits and endocytic vescicles near the apical membrane of the proximal tubules




Genotype
MGI:5140922
cn51
Allelic
Composition
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pdgfrbtm12(Pdgfrb)Sor mutation (0 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5140924
cn52
Allelic
Composition
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pdgfrbtm13(Pdgfrb)Sor mutation (1 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• during the second week




Genotype
MGI:5140927
cn53
Allelic
Composition
Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pdgfrbtm14(Pdgfrb)Sor mutation (1 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• during the second week




Genotype
MGI:5284833
cn54
Allelic
Composition
Nrastm1Tyj/Nras+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Nrastm1Tyj mutation (1 available); any Nras mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3698139
cn55
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Rasgrf1tm4.1Pds/Rasgrf1+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• loss of paternal repeats does not affect expression of Rasgrf1 in neonatal brain
• loss of paternal repeats at E5.5 in the epiblast does not result in changes to methylation state of the paternal allele, in contrast with deletion earlier in development




Genotype
MGI:5644692
cn56
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ mice display hindlimb curl

mortality/aging
• nearly 100% of mice die before P30

growth/size/body
• body weights are different from controls starting at P4

behavior/neurological
• seen at P14
• seen by P14
• mice develop gait abnormalities at P10

muscle
• end-stage mutants exhibit scattered and grouped atrophic muscle fibers and presence of pyknotic myofibers indicating muscle atrophy

nervous system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• mice, however do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords
• mice that die by P30 exhibit activation of astrocytes in the brain and spinal cord
• end-stage mutants show abnormalities and degeneration of the neuromuscular junctions

hematopoietic system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• mice, however do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords

immune system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• mice, however do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 6 DOID:0060198 OMIM:608030
J:216672




Genotype
MGI:5644693
cn57
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ mice display hindlimb curl

mortality/aging
• about 50% of mice die before P30

growth/size/body
• mice that survive past P30 exhibit reduced body mass

behavior/neurological
• mice that survive past P30 display a subtle motor impairment
• mice exhibit reduced righting ability, however to a lesser extent than in conditional Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mice
• mice exhibit hindlimb clasping, but to a lesser extent than in conditional Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mice
• on the rotarod, mice that escape early lethality show normal performance on day 1 of testing, however show impaired motor function on day 2 of testing
• mice exhibit reduced grip strength, however to a lesser extent than in conditional Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mice
• mice that escape early lethality show less activity over a 9-day period on voluntary running wheels
• however, food intake is not altered
• mice develop gait abnormalities that are less severe than in conditional Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mice
• gait analysis of mice that escape early lethality shows that the braking phase is greater in the forelimbs and the swing phase is reduced in the hindlimbs
• in the ladder-walking test, the forelimbs of mice that escape early lethality have more errors in stepping with few deficits in the hindlimbs
• interaction with juvenile mice is reduced at 4 months of age
• when introduced to intruder adult mice, mutants do not show any deficits before 8 months of age, at which time they show reduced chasing behavior

muscle
• end-stage mutants exhibit scattered and grouped atrophic muscle fibers, although to a lower extent than in conditional Tg(CAG-lacZ,-FUS,-EGFP)629Gyu mice

nervous system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• however, mice that escape early lethality do not exhibit microglial and astrocyte activation in the brain and spinal cord
• mice also do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords
• mice that die by P30 exhibit activation of astrocytes in the brain and spinal cord
• dendritic intersections and cumulative area of dendrites are reduced in spinal motor neurons at P18 and these deficits are significant and persistent at P60
• fewer intersections and reduced cumulative area in the apical and basal dendrites in neurons of sensorimotor cortex layers IV-V at P18 and P60
• decrease in the number and density of mature spines
• end-stage mutants show abnormalities and degeneration of neuromuscular junctions

hematopoietic system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• however, mice that escape early lethality do not exhibit microglial and astrocyte activation in the brain and spinal cord
• mice also do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords

immune system
• mice that die by P30 exhibit activation of microglia in the brain and spinal cord
• however, mice that escape early lethality do not exhibit microglial and astrocyte activation in the brain and spinal cord
• mice also do not exhibit degeneration of axons in the dorsal corticospinal tract or lateral columns, or in the dorsal or ventral roots, indicating that descending motor axons are not altered, show no motor neuron loss in the cervical spinal cord, and no FUS protein aggregates in the brain or spinal cords

taste/olfaction
N
• mice exhibit normal olfaction and cognitive function

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 6 DOID:0060198 OMIM:608030
J:216672




Genotype
MGI:5316229
cn58
Allelic
Composition
Atmtm2Pmc/Atmtm2Pmc
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2Pmc mutation (0 available); any Atm mutation (32 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• resistance to radiation induced DNA damage-induced apoptosis in neural tissues




Genotype
MGI:5896387
cn59
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Sec24ctm1c(EUCOMM)Wtsi/Sec24ctm1c(EUCOMM)Wtsi
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Sec24ctm1c(EUCOMM)Wtsi mutation (1 available); any Sec24c mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die before 2 weeks of age




Genotype
MGI:3615265
cn60
Allelic
Composition
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

neoplasm
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3615264
cn61
Allelic
Composition
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

neoplasm
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:4843164
cn62
Allelic
Composition
Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Pkd2tm1.1Tjwt mutation (1 available); any Pkd2 mutation (16 available)
Pkd2tm1.2Tjwt mutation (0 available); any Pkd2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

endocrine/exocrine glands

cardiovascular system

homeostasis/metabolism
• in neonates

growth/size/body

renal/urinary system




Genotype
MGI:3056368
cn63
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Nodaltm1Rob/Nodaltm5Rob
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Nodaltm1Rob mutation (1 available); any Nodal mutation (15 available)
Nodaltm5Rob mutation (0 available); any Nodal mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• development was variable
• fail to rotate their proximal distal axis
• variable amounts of anterior truncation at E6.5
• in severe cases an elongate morphology at E6.5
• profound anterior truncations by E8.5
• embryos occasionally protrude outside the yolk sac at E6.5




Genotype
MGI:3779089
cn64
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Mfn1tm2Dcc/Mfn1+
Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Mfn1tm2Dcc mutation (2 available); any Mfn1 mutation (6 available)
Mfn2tm1Dcc mutation (0 available); any Mfn2 mutation (20 available)
Mfn2tm3Dcc mutation (2 available); any Mfn2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after birth, about one third of mutant mice die on postnatal day 1
• mutant pups are born at appropriate Mendelian ratio
• mutant mice that survive the neonatal period die by P17

behavior/neurological
• mice surviving beyond P1 cannot easily regain posture when placed on their backs
• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body
• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder




Genotype
MGI:3779087
cn65
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm3Dcc/Mfn2+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Mfn1tm1Dcc mutation (0 available); any Mfn1 mutation (6 available)
Mfn1tm2Dcc mutation (2 available); any Mfn1 mutation (6 available)
Mfn2tm3Dcc mutation (2 available); any Mfn2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3779093
cn66
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Mfn2tm1Dcc mutation (0 available); any Mfn2 mutation (20 available)
Mfn2tm3Dcc mutation (2 available); any Mfn2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice surviving beyond P1 cannot easily regain posture when placed on their backs
• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body
• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

nervous system
• severe defect in postnatal cerebellar growth

mortality/aging
• after birth, about one third of mutant mice die on postnatal day 1
• mutant mice that survive the neonatal period die by P17
• mutant pups are born at appropriate Mendelian ratio




Genotype
MGI:3779086
cn67
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Mfn1tm1Dcc mutation (0 available); any Mfn1 mutation (6 available)
Mfn1tm2Dcc mutation (2 available); any Mfn1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutant mice survive through adulthood with no obvious defects
• both males and females are fully fertile and healthy to at least one year




Genotype
MGI:3779088
cn68
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Mfn1tm1Dcc mutation (0 available); any Mfn1 mutation (6 available)
Mfn1tm2Dcc mutation (2 available); any Mfn1 mutation (6 available)
Mfn2tm1Dcc mutation (0 available); any Mfn2 mutation (20 available)
Mfn2tm3Dcc mutation (2 available); any Mfn2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4437795
cn69
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Smad1tm2Rob/Smad1tm2Sor
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
Smad1tm2Rob mutation (1 available); any Smad1 mutation (9 available)
Smad1tm2Sor mutation (1 available); any Smad1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 24% of pups die at birth

digestive/alimentary system
• in severely affected newborns, the stomach is ruptured
• the stomach epithelium is very thin
• the muscular layer of the stomach is almost completely absent
• bloated stomach with accumulation of air in the abdomen

growth/size/body
• bloated stomach with accumulation of air in the abdomen

muscle
• the muscular layer of the stomach is almost completely absent




Genotype
MGI:4353414
cn70
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (5 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between E11.5 and E15.5

cardiovascular system
• seen at E11.5 in some embryos

homeostasis/metabolism
• seen at E11.5 in some embryos




Genotype
MGI:3777090
cn71
Allelic
Composition
Mef2dtm3Eno/Mef2dtm3Eno
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (49 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 21 days of thoracic aortic constriction (TAC), mutant hearts display only a 27.7% increase in heart weight/tibia length, compared to 59% in wild-type hearts
• mutant hearts undergo less cardiac remodeling than wild-type in response to TAC
• mutants do not display fibrosis as result of pressure overload hypertrophy while extensive fibrosis is observed in wild-type
• after pressure overload, mutant cardiomyocytes exhibit a considerably smaller increase in cross-sectional area composed to wild-type cardiomyocytes
• 21 days after TAC, mutant hearts show a smaller increase in heart weight/tibia length ratio versus wild-type
• after TAC, LV end-systolic diameter of mutant hearts is only marginally increased compared to wild-type hearts after TAC
• mutant hearts display a high level of resistance to reduction in heart muscle contractility after 21 days of TAC, whereas wild-type hearts show pronounced reduction in contractility

muscle
• after pressure overload, mutant cardiomyocytes exhibit a considerably smaller increase in cross-sectional area composed to wild-type cardiomyocytes
• mutant hearts display a high level of resistance to reduction in heart muscle contractility after 21 days of TAC, whereas wild-type hearts show pronounced reduction in contractility




Genotype
MGI:4353413
cn72
Allelic
Composition
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable unlike homozygous null mice

integument





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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory