Mef2d^tm3Eno
Targeted Allele Detail

Summary

• Symbol: Mef2d^tm3Eno
• Name: myocyte enhancer factor 2D; targeted mutation 3, Eric Olson
• MGI ID: MGI:3774341
• Gene: Mef2d Location: Chr3:88049679-88079393 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Mef2d^tm3Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130825
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. The neo cassette was subsequently removed by germ-line, flp-mediated recombination to yield a floxed exon 3. (J:130825)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2d Mutation: 64 strains or lines available

References

• Original: J:130825 Kim Y, et al., The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest. 2008 Jan;118(1):124-32
• All: 13 reference(s)