Fosl1^tm2Wag
Targeted Allele Detail

Summary

• Symbol: Fosl1^tm2Wag
• Name: fos-like antigen 1; targeted mutation 2, Erwin F Wagner
• MGI ID: MGI:3055991
• Synonyms: Fosl1^flox, fra-1^f
• Gene: Fosl1 Location: Chr19:5497726-5505966 bp, + strand Genetic Position: Chr19, 4.33 cM
• Alliance: Fosl1^tm2Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93053
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked by loxP sites upon homologous recombination. Included in the floxed segment was a neo marker, and a GFP 3' to the downstream loxP site. Exons 3 and 4 contain the dimerization and the DNA-binding domains. (J:93053)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fosl1 Mutation: 16 strains or lines available

References

• Original: J:93053 Eferl R, et al., The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J. 2004 Jul 21;23(14):2789-99
• All: 18 reference(s)