Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation
(0 available);
any
Fosl1 mutation
(16 available)
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normal phenotype
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• no overt abnormalities are seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation
(0 available);
any
Fosl1 mutation
(16 available)
Meox2tm1(cre)Sor mutation
(3 available);
any
Meox2 mutation
(18 available)
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skeleton
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• deposition of mineralized extracellular matrix is strongly reduced
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• progressive loss of bone mass
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• reduced bone mass is seen in the lumbar vertebral bodies and long bones and vertebral trabecular thickness is reduced in 6 week and 3 month old mutants
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cardiovascular system
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N |
• transaortic constriction of the aorta (TAC) results in a comparable hypertrophic response as in controls
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liver/biliary system
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N |
• in a model of liver fibrosis, mice exhibit a normal response
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cellular
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• deposition of mineralized extracellular matrix is strongly reduced
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Analysis Tools